Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects

Po, Harvey; Pruessner, Jens C.; Czechowska, Yvonne; Lepage, Martín

doi:10.1038/sj.mp.4002021

Cited by 231 publications

(177 citation statements)

References 60 publications

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“…In healthy subjects the IMPC is involved in the processing of emotional stimuli (Amodio and Frith, 2006;Phan et al, 2002), attention (Geday et al, 2003(Geday et al, , 2007Raichle et al, 2001), and social perception (Geday et al, 2003;Harvey et al, 2007b). In the present study, we focused on emotional reactivity, because the IMPC as ROI is deactivated by attention to an emotional stimulus (Geday et al, 2003(Geday et al, , 2007.…”

Section: Discussionmentioning

confidence: 93%

Monoaminergic modulation of emotional impact in the inferomedial prefrontal cortex

Geday

Gjedde

2008

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People assess the impact of emotionally loaded images differently. We define this impact as the average difference between individual ratings of standardized ''pleasant'' and ''unpleasant'' images. To determine the neuroanatomical correlate of a hypothetical interaction between emotional impact and cerebral excitability, we first determined the individual effect on cerebral blood flow of a pharmacological challenge with the monoamine reuptake inhibitor clomipramine in nine healthy volunteers. In a later, independent, session the nine volunteers rated pleasant, neutral, and unpleasant images of the standard Empathy Picture System on a scale from 13 to 23. We then used regression analysis to identify sites in the ventromedial prefrontal cortex at which the two separately acquired measures, blood flow change and emotional impact of images, correlated significantly. The regression analysis identified a locus in Brodmann's area 11 of the inferomedial prefrontal cortex (IMPC) at which these two separate measures had significant inverse correlation. Thus, under the specific circumstance of positron emission tomography (PET) of a pharmacological challenge, a key region of the inferomedial prefrontal cortex underwent deactivation in proportion to a separately rated emotional impact of a stimulus. We propose a specific pharmacodynamic mechanism that explains the correlation between the emotional impact and the effect of a serotonin-noradrenaline reuptake inhibitor on cerebral blood flow.

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Section: Discussionmentioning

confidence: 93%

Monoaminergic modulation of emotional impact in the inferomedial prefrontal cortex

Geday

Gjedde

2008

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“…MOFC lesions in humans relate to deficits in reward-based learning, which can result in apathy and lack of affect (Hornak et al 2003;Fellows & Farah, 2005;Fisher et al 2011;Kühn & Gallinat, 2012). Accordingly, functional and structural imaging studies in healthy cohorts have reported associations between MOFC activity (and thickness) and characteristics that are comparable to the negative symptoms observed in schizophrenia (Harvey et al 2007;Ducharme et al 2014). For instance, functional connectivity between the orbitofrontal cortex and the dorsolateral prefrontal cortex was found to be dependent on levels of motivation (Szatkowska et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

et al. 2017

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Background. Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity. Results. Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (β std = −0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.Conclusions. Using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.

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“…Specifically, given prior research relating anhedonia to reward system dysfunction in multiple psychiatric disorders (Juckel et al, 2006;Wolf, 2006;Harvey et al, 2007;Wolf et al, 2008;Pizzagalli et al, 2009;Treadway and Zald, 2011;Gabbay et al, 2013;Hägele et al, 2014) anhedonia was examined using a sub-set of anhedonia-related items from the BDI (Joiner et al, 2003). Furthermore, we similarly examined the relationship with BDI items unrelated to anhedonia.…”

Section: Supplementary Analyses Of Additional Symptom Dimensionsmentioning

confidence: 99%

Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

Satterthwaite

Kable

Vandekar

et al. 2015

Neuropsychopharmacol

213

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Unipolar and bipolar depressive episodes have a similar clinical presentation that suggests common dysfunction of the brain's reward system. Here, we evaluated the relationship of both dimensional depression severity and diagnostic category to reward system function in both bipolar and unipolar depression. In total, 89 adults were included, including 27 with bipolar depression, 25 with unipolar depression, and 37 healthy comparison subjects. Subjects completed both a monetary reward task and a resting-state acquisition during 3T BOLD fMRI. Across disorders, depression severity was significantly associated with reduced activation for wins compared with losses in bilateral ventral striatum, anterior cingulate cortex, posterior cingulate cortex, and right anterior insula. Resting-state connectivity within this reward network was also diminished in proportion to depression severity, most notably connectivity strength in the left ventral striatum. In addition, there were categorical differences between patient groups: resting-state connectivity at multiple reward network nodes was higher in bipolar than in unipolar depression. Reduced reward system task activation and resting-state connectivity therefore appear to be a brain phenotype that is dimensionally related to depression severity in both bipolar and unipolar depression. In contrast, categorical differences in reward system resting connectivity between unipolar and bipolar depression may reflect differential risk of mania. Reward system dysfunction thus represents a common brain mechanism with relevance that spans categories of psychiatric diagnosis.

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Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects

Cited by 231 publications

References 60 publications

Monoaminergic modulation of emotional impact in the inferomedial prefrontal cortex

Monoaminergic modulation of emotional impact in the inferomedial prefrontal cortex

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

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