Inhibition of N-Type Voltage-Activated Calcium Channels in Rat Dorsal Root Ganglion Neurons by P2Y Receptors Is a Possible Mechanism of ADP-Induced Analgesia

International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

“…Glial cells in the brain also stain positive (Moran-Jiminez and Matute, 2000;Fong et al, 2002;Weick et al, 2003;Franke et al, 2004). The receptor is also expressed in sensory neurons (Nakamura and Strittmatter, 1996;Fong et al, 2002;Ruan and Burnstock, 2003;Gerevich et al, 2004), consistent with a potential role for P2Y 1 receptors in sensory reception. The presence of P2Y 1 -like immunoreactivity (Fong et al, 2002) and mRNA (Buvinic et al, 2002;Kaiser and Buxton, 2002) in rat arterial endothelial cells is also consistent with the well-characterized vasodilatory activity of P2Y 1 receptors.…”

Pathophysiology and Therapeutic Potential of Purinergic Signaling

“…Both P2X 3 (homomultimer) and P2X 2/3 (heteromultimer) receptors mediate nociceptive afferent responses, but the proportions vary in different organs. P2Y 1 receptors have also been demonstrated in a subpopulation of sensory neurons that colocalise with P2X 3 receptors (Ruan and Burnstock, 2003;Gerevich et al, 2004).…”

P2Y purinergic receptors: New targets for analgesic and antimigraine drugs

“…The outcome of VGCC inhibition is a decrease in sensory transmitter release from DR terminals in the spinal cord, which in turn diminishes transmission in ascending spinal nerve (pain) pathways [38]. P2Y receptor expression in sensory nerve terminals could control ATP actions on algogenic P2X subtypes, as well.…”