Ketamine Attenuates Delirium After Cardiac Surgery With Cardiopulmonary Bypass

Hudetz, Judith A.; Patterson, Kathleen; Iqbal, Zafar; Gandhi, Sweeta D.; Byrne, Alison J.; Hudetz, Anthony G.; Warltier, David C.; Pagel, Paul S.

doi:10.1053/j.jvca.2008.12.021

Cited by 231 publications

(145 citation statements)

References 38 publications

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“…It is considered the agent of choice in children and burn victims [30] . Additionally, administration of ketamine during induction, at least in patients with cardiopulmonary bypass, may attenuate post-operative delirium [31] .…”

Section: Side Effectsmentioning

confidence: 99%

Ketamine use in current clinical practice

2016

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After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. Nowadays, ketamine is also being utilized for pediatric pain control in emergency department, with its anti-hyperalgesic and anti-inflammatory effects being revealed in acute and chronic pain management. Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects. This article provides an overview of the drug's pharmacokinetics and pharmacodynamics while also discussing the potential benefits and risks of ketamine administration in various clinical settings.

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Section: Side Effectsmentioning

confidence: 99%

Ketamine use in current clinical practice

2016

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“…Thus, it is possible that general anesthesia could be a factor in the pathogenesis of POCD (Fodale, et al, 2010). However, in his study, Hudetz et al (J. Hudetz et al, 2009;J. A. Hudetz et al, 2009) found that a single administration of ketamine, 0.5 mg/kg, during the induction of anesthesia reduced the incidence of POCD to one week after a cardiac surgery.…”

Section: Pocd and Anesthesiamentioning

confidence: 95%

Postoperative Cognitive Dysfunction (POCD) and Markers of Brain Damage After Big Joints Arthroplasty

Tomaszewski¹

2012

Recent Advances in Arthroplasty

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“…Oftast voru notuð greiningarviðmið DSM-IV 33,[36][37][38][39][40][41] eða stöðluð matstaeki. 31,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] Algengi óráðs var laegst þegar greiningin byggði á öðrum greiningarviðmiðum og þar sem ekki fór fram reglubundin skimun eða mat á óráðseinkennum með stöðluðum matstaekjum. 58,59 Annar þáttur sem skýrir breytileikann er að úrtök rannsóknanna voru ólík varðandi aldur þátttakenda og þátttöku einstaklinga með þekkta heilabilun eða óráð fyrir skurðaðgerð.…”

Section: Niðurstöðurunclassified