Left inferior frontal gyrus is critical for response inhibition

Swick, Diane; Ashley, Victoria; Turken, And U.

doi:10.1186/1471-2202-9-102

Cited by 607 publications

(430 citation statements)

References 71 publications

(79 reference statements)

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“…Consistent with the present study, a recent meta-analysis of BP and response inhibition found that BP patients showed right IFC hypoactivation across mood states (Hajek et al, 2013). The IFC, particularly right lateralized, is a region pivotal to response inhibition, as supported by lesion studies (Aron et al, 2004;Swick et al, 2008;Funderud et al, 2013). This persistent reduction in IFC activation in BP may reflect less activity of neurons involved in inhibition and may help to explain the continued impulsivity symptoms reported in some BP patients even while euthymic (Swann et al, 2001).…”

Section: Discussionsupporting

confidence: 89%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Discussionsupporting

confidence: 89%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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“…17,18 These results are in agreement with previous studies investigating the implicit regulation of food choice and craving for cigarettes. For example, Hare et al 8 found increased responses in the left DLPFC when dieters with high self-control (compared with dieters with low self-control; as assessed by choice of healthy or unhealthy food) chose healthy over unhealthy food in an implicit regulation experiment.…”

Section: Discussionsupporting

confidence: 83%

Neural correlates of the volitional regulation of the desire for food

et al. 2011

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Objective: In this study, we investigate the brain mechanisms of the conscious regulation of the desire for food using functional magnetic resonance imaging. Further, we examine associations between hemodynamic responses and participants' cognitive restraint of eating (CRE), as well as their susceptibility to uncontrolled eating. Subjects: Seventeen non-vegetarian, right-handed, female Caucasian participants (age: 20-30 years, mean 25.3 years±3.1 s.d.; BMI: 20.2-31.2 kg m À2 , mean 25.1 ± 3.5 s.d.). Measurements: During scanning, our participants viewed pictures of food items they had pre-rated according to tastiness and healthiness. Participants were either allowed to admit to the desire for the food (ADMIT) or they were instructed to downregulate their desire using a cognitive reappraisal strategy, that is, thinking of negative long-term health-related and social consequences (REGULATE).Results: Comparing the hemodynamic responses of the REGULATE with the ADMIT condition, we observed robust activation in the dorsolateral prefrontal cortex (DLPFC), the pre-supplementary motor area, the inferior frontal gyrus (IFG), the dorsal striatum (DS), the bilateral orbitofrontal cortex (OFC), the anterior insula and the temporo-parietal junction (TPJ). Activation in the DLPFC and the DS strongly correlated with the degree of dietary restraint under both conditions. Conclusion: Cortical activation in the DLPFC, the pre-supplementary motor area and the inferior frontal gyrus (IFG) are known to underpin top-down control, inhibition of learned associations and pre-potent responses. The observed hemodynamic responses in the lateral OFC, the DS, the anterior insula and the TPJ support the notion of reward valuation and integration, interoceptive awareness, and self-reflection as key processes during active regulation of desire for food. In conclusion, an active reappraisal of unhealthy food recruits the brain's valuation system in combination with prefrontal cognitive control areas associated with response inhibition. The correlations between brain responses and CRE suggest that individuals with increased cognitive restraint show an automatic predisposition to regulate the hedonic aspects of food stimuli. This cognitive control might be necessary to counterbalance a lack of homeostatic mechanisms.

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“…The left IFG has shown causal relevance to stopping behaviours in patients with lesions [46] and also increased BOLD activity in healthy participants during action restraint on a go-nogo task [47] or tasks requiring inhibitory control for interference resolution [48]. Some imaging evidence with the stop signal task has considered the right IFG as a key node in the inhibitory network [49]; whereas other imaging studies attributed a role in attention rather than inhibition to the IFG [50].…”

Section: Motor Inhibitionmentioning

confidence: 99%