Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research

Dodson, Michael V.; Hausman, Gary; Guan, Leluo; Du, Min; Rasmussen, Theodore P.; Poulos, Sylvia P.; Mir, P. S.; Bergen, Werner G.; Fernyhough, Melinda E.; McFarland, Douglas C.; Rhoads, Robert P.; Soret, B.; Reecy, James M.; Velleman, Sandra G.; Jiang, Zhihua

doi:10.7150/ijbs.6.691

Cited by 95 publications

(84 citation statements)

References 55 publications

(79 reference statements)

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“…Já a obesidade hiperplásica é causada por um número excessivo de adipócitos, que podem ser controlados geneticamente, mas estão certamente envolvidos com a excessiva e precoce ingestão energética (Guimarães and Tudury, 2006). Segundo Dodson et al (2010) o organismo é capaz de aumentar o número de adipócitos (células repletas de lipídios), mas não é capaz de diminuir o seu número. Este efeito indica que a gordura corporal sempre pode aumentar determinada pelo número total de adipócitos e por sua necessidade de se manterem repletos de lipídeos.…”

Section: Tipos De Obesidadeunclassified

Obesidade canina: Revisão

Silva

Brito

Freire

et al. 2017

Pubvet

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RESUMO.A obesidade é uma condição patológica caracterizada por um acúmulo de gordura maior que o necessário no corpo, capaz de prejudicar a boa saúde e o bem-estar animal. Pode ocorrer em consequência da sobrecarga de fornecimento de carboidratos e gorduras excedendo o gasto energético diário, castração, sedentarismo, além de problemas endócrinos e genéticos. Essa variação na epidemiologia da obesidade vem contribuindo para maior dificuldade de identificação da causa primaria da enfermidade. Diante disso esta revisão tem por objetivo expor os aspectos epidemiológicos, clínicos, os métodos disponíveis para diagnostico da obesidade e algumas formas de tratamento. Palavras chave: Canídeos, epidemiologia, sobrepesoCanine obesity: Review ABSTRACT. Obesity is a pathological condition characterized by an accumulation of fat that is greater than necessary in the body, capable of impairing good health and animal welfare. It can occur because of the overload of carbohydrate and fat supply, exceeding daily energy expenditure, castration, sedentary lifestyle, as well as endocrine and genetic problems. This variation in the epidemiology of obesity has contributed to a greater difficulty in identifying the primary cause of the disease. Therefore, the purpose of this review is to present the epidemiological and clinical aspects, the methods available for the diagnosis of obesity and some forms of treatment. Key words: Canids, epidemiology, overweightObesidad Canina: Revisión RESUMO. La obesidad es una condición patológica caracterizada por una acumulación de grasa mayor de lo necesario en el cuerpo, capaz de perjudicar una buena salud y el bienestar animal. Puede resultar en consecución de la sobrecarga de suministro de carbohidratos y grasas que exceden el gasto energético diario, castración, sedentarismo, además de problemas endócrinos y genéticos. La variación en la epidemiología de la obesidad viene contribuyendo a la mayor dificultad de la identificación de la causa primaria de la enfermedad. Frente a eso, esta revisión tiene por objetivo exponer los aspectos epidemiológicos, clínicos, los métodos disponibles para el diagnóstico de la obesidad y algunas formas de tratamiento.

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Section: Tipos De Obesidadeunclassified

Obesidade canina: Revisão

Silva

Brito

Freire

et al. 2017

Pubvet

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“…Most of structural fat found as biomembrane integral constituent, especially as phospholipid, whereas deposit lipid found in interfascilular adipose tissue, most as triglycerides (TG) and smaller part as mono and diglycerides, cholesterol, cholesterylester (CE), non esterified fatty acids (NEFA), and phospholipids (Dodson et al, 2010).…”

Section: Intramuscular Fatmentioning

confidence: 99%

“…Linoleic acid was phosphatidilcholline component, which was the main phospholipid in high density lipoprotein (HDL). Those could carry out the cholesterol from periphery tissue as well as other lipoprotein for its oxydation in the liver (Dodson et al, 2010). To obtain the real benefit of PUFA in ruminant feeding, supplementation of PUFA source was required in adequate level and in protected form.…”

Section: Introductionmentioning

confidence: 99%

Inclusion of Kapok Seed Oil in the Diet for Growing of Thin-Tailed Sheep to Reduce Cholesterol and to Improve Omega-Six Fatty Acid Contents of Lamb

Widiyanto

Soejono

Hartadi

et al. 2012

J. Indonesian Trop. Anim. Agric.

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ABSTRAKPenelitian ini dilakukan untuk mengkaji pengaruh suplementasi minyak biji kapok (MBK) terproteksi dalam kombinasinya dengan konsentrat, dalam hal ini bekatul terhadap status lipida daging domba ekor tipis (DET) yang mendapat rumput lapangan (RL) sebagai pakan basal. Sebanyak 24 ekor domba DET jantan digunakan sebagai bahan percobaan yang dibagi dalam 8 kelompok perlakuan. Terdapat 2 faktor perlakuan, yakni suplementasi MBK (faktor I) dan suplementasi konsentrat yakni bekatul (faktor II). Faktor I terdiri atas 2 aras, yakni 0% (S0) dan 10% (S1), sedangkan faktor II terdiri atas 4 aras, yakni 0% (K0); 15% (K1); 30% (K2) dan 45% (K3), berdasarkan konsumsi BK. Variabel yang diukur meliputi kandungan lemak intramuskuler (LIM), bilangan iodin (BI) asam lemak daging, kandungan kolesterol dan asam lemak omega 6 daging (dalam hal ini asam linoleat). Data yang terkumpul diolah secara statistik dengan analisis ragam, pola perlakuan faktorial 2 x 4 dalam rancangan acak lengkap (RAL). Kandungan LIM domba-domba yang mendapat suplemen MBK pada aras 0 dan dedak halus 15% tidak berbeda nyata dengan kandungan LIM domba-domba tanpa suplementasi MBK dengan aras pemberian bekatul yang sama (3,45 dan 3,99 vs 3,01 dan 3,75% ABSTRACTThis research was conducted to study the influence of protected kapok seed oil (PKSO) supplementation in its combination with concentrate, in this case was rice bran (RB) on lipid content of thin tailed sheep received field grass as basal feed. A number of 24 heads of male thin-tailed sheep were used as experimental material. These sheep were divided into 8 treatment groups. There were two treatment factors, i.e. : PKSO supplementation (S) as factor I and RB supplementation (K) as factor II. Factor I consisted of 2 levels, i.e. 0% (S0) and 10% (S1), whereas factor II consist of 4 levels, i.e. 0% (K0), 15% (K1), 30% (K2) and 45% (K3), respectively, based on dry matter (DM) intake. Several variables were measured, namely content of intra muscular fat (IMF), iodine number of muscular fatty acid, content of meat cholesterol and omega 6 fatty acid (in this case linoleic acid). The collected data were statistically analyzed by analysis of variance with factorial treatment pattern (2 x 4) in completely randomized design (CRD). Content of IMF in sheep supplemented with 0 and 15% KSO levels was not significantly different from those without kapok seed oil (KSO) supplementation at the same level of RB feeding (3.45 and 3.99% vs 3.01 and 3.75%). Supplementation of protected KSO in combination with 30 and 45% RP resulted in significantly increased (P < 0. vs 89.21 and 72.63 mg/100 g ) also significantly increased (P < 0.05) linoleic acid proportion (15.52 and 18.25% vs 3.68 and 4.04%) and iodine number (12.52 and 10.25 vs 4.09 and 4.98).

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“…Comparisons between Wagyu cattle and other breeds regarding cell biology and general adipogenesis have been reported in several studies, such as those by Oikawa et al (2000), Hausman et al (2009), Dodson et al (2010a and Duarte et al (2013). Some studies comparing Wagyu cattle with other breeds (Hausman et al, 2009;Dodson et al, 2010a;Duarte et al, 2013) have emphasized the uniqueness of this breed and the importance of better understanding adipogenesis, mainly because its increased accumulation of fat within the skeletal muscle, which seems to not follow the same pattern of other adipose tissue depots.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies comparing Wagyu cattle with other breeds (Hausman et al, 2009;Dodson et al, 2010a;Duarte et al, 2013) have emphasized the uniqueness of this breed and the importance of better understanding adipogenesis, mainly because its increased accumulation of fat within the skeletal muscle, which seems to not follow the same pattern of other adipose tissue depots. Consequently, Wagyu cattle may present a highly marbled beef without an increase of overall fatness, making this breed an unique animal model for the understanding of this phenomena.…”

Section: Introductionmentioning

confidence: 99%

Review: Animal model and the current understanding of molecule dynamics of adipogenesis

Campos

Duarte

Guimarães

et al. 2016

Animal

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Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals.

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Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research

Cited by 95 publications

References 55 publications

Obesidade canina: Revisão

Obesidade canina: Revisão

Inclusion of Kapok Seed Oil in the Diet for Growing of Thin-Tailed Sheep to Reduce Cholesterol and to Improve Omega-Six Fatty Acid Contents of Lamb

Review: Animal model and the current understanding of molecule dynamics of adipogenesis

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