Looking Back at the Next 40 Years of ASD Neuroscience Research

McPartland, James C.; Lerner, Matthew D.; Bhat, Anjana; Clarkson, Tessa; Jack, Allison; Koohsari, Sheida; Matuskey, David; McQuaid, Goldie; Su, Wan-Chun; Trevisan, Dominic A.

doi:10.1007/s10803-021-05095-5

Cited by 18 publications

(18 citation statements)

References 277 publications

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“…With advances in neuroimaging techniques, more and more intervention studies are including neuroimaging tools as objective outcome measures of intervention effects ( 58 ). Systematic reviews involving healthy populations support the use of neuroimaging tools as outcome measures and propose potential mechanisms underlying training-related improvements ( 73 , 79 ).…”

Section: Discussionmentioning

confidence: 99%

“…EEGbased neurobiomarkers (i.e., slow and fast-wave EEG activity, and the ERPs such as P3b, N2 peaks) could be used to study neural effects of movement interventions on children's networks related to cognitive/executive functioning and social functioning. Besides EEG, other non-invasive, childfriendly techniques include fNIRS (58,84). Using fNIRS, our research group has reported differences in cortical activation in infants at-risk for and children with ASD during socially embedded actions (i.e., actions performed with adults and caregivers), solo movements, and action observation compared to healthy children and adults during social interaction as well as interpersonal synchrony tasks involving reaching and whole-body movements (67)(68)(69)(70)(71)(72).…”

Section: Implications and Recommendation For Future Researchmentioning

confidence: 99%

“…Besides the behavioral outcomes, neuroimaging assessments, such as structural Magnetic Resonance Imaging (MRI) including Diffusion Tensor Imaging (DTI), functional Magnetic Resonance Imaging (fMRI), Electroencephalogram (EEG), and functional Near-Infrared Spectroscopy (fNIRS), have been used to develop objective measures of abnormalities in brain structure and function associated with the aforementioned developmental disabilities ( 58 ). A meta-analytic review of MRI/fMRI studies reported shared as well as distinct structural and functional brain abnormalities in individuals with ASD and ADHD ( 59 ).…”

Section: Introductionmentioning

confidence: 99%

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Neural Effects of Physical Activity and Movement Interventions in Individuals With Developmental Disabilities–A Systematic Review

Amonkar

Cleffi

et al. 2022

Front. Psychiatry

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Individuals with developmental disabilities present with perceptuo-motor, social communication, and cognitive impairments that often relate to underlying atypical brain structure and functioning. Physical activity/movement interventions improve behavioral performance of individuals with and without developmental disabilities. Majority of the evidence on potential neural mechanisms explaining the impact of physical activity/movement interventions is based on studies in individuals with typical development; there is a dearth of systematic reviews synthesizing the neural effects of physical activity/movement interventions in individuals with developmental disabilities. In this systematic review, we have gathered evidence on the neural effects of physical activity/movement interventions from 32 papers reporting substantial neural effects and behavioral improvements in individuals with developmental disabilities. Chronic intervention effects (multiple sessions) were greater than acute intervention effects (single session). Specifically, using electroencephalogram, functional magnetic resonance imaging, diffusion tensor imaging, and functional near-infrared spectroscopy, studies found physical activity/movement intervention-related changes in neural activity, indicating normalization of cortical arousal in individuals with attention-deficit /hyperactivity disorder (ADHD), increased social brain connectivity in individuals with autism spectrum disorder (ASD), and more efficient executive functioning processes in individuals with a wide range of other developmental disabilities. Despite promising results, more research is clearly needed in this area with larger sample sizes, using standardized neuroimaging tools/variables, and across multiple diagnoses to further explore the neural mechanisms underlying physical activity/movement interventions and to replicate findings from the present review.

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Section: Discussionmentioning

confidence: 99%

Section: Implications and Recommendation For Future Researchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neural Effects of Physical Activity and Movement Interventions in Individuals With Developmental Disabilities–A Systematic Review

Amonkar

Cleffi

et al. 2022

Front. Psychiatry

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“…It has been recently suggested that an early assessment of pupil size modulation and visual behavior might improve the diagnostic process of ASD 66,77,87,89 . Currently, ASD diagnosis and follow-up almost entirely rely on phenotypic information collected via clinical measures and parental input that are highly prone to subjective bias 90 . Moreover, the late appearance of some behavioral autistic traits often delays the diagnosis until mid-childhood 91,92 .…”

Section: Discussionmentioning

confidence: 99%

The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children

Mazziotti

Scaffei

Conti

et al. 2021

Preprint

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Autistic traits represent a continuum dimension across the population, with autism spectrum disorder (ASD) being the extreme end of the distribution. Accumulating evidence shows that neuroanatomical and neurofunctional profiles described in relatives of ASD individuals reflect an intermediate neurobiological pattern between the clinical population and healthy controls. This suggests that quantitative measures detecting autistic traits in the general population represent potential candidates for the development of biomarkers identifying early pathophysiological processes associated with ASD. Functional near-infrared spectroscopy (fNIRS) has been extensively employed to investigate neural development and function. In contrast, the potential of fNIRS to define reliable biomarkers of brain activity has been barely explored. Features of non-invasiveness, portability, ease of administration and low-operating costs make fNIRS a suitable instrument to assess brain function for differential diagnosis, follow-up, analysis of treatment outcomes and personalized medicine in several neurological conditions. Here, we introduce a novel standardized procedure with high entertaining value to measure hemodynamic responses (HDR) in the occipital cortex of adult subjects and children. We found that the variability of evoked HDR correlates with the autistic traits of children, assessed by the Autism-Spectrum Quotient. Interestingly, HDR amplitude was especially linked to social and communication features, representing the core symptoms of ASD. These findings establish a quick and easy strategy for measuring visually-evoked cortical activity with fNIRS that optimize the compliance of young subjects, setting the background for testing the diagnostic value of fNIRS visual measurements in the ASD clinical population.

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“…The growing consensus on best approaches to diagnosis of autism has also significantly advanced work in the area of genetics; this work, first begun in the 1970's, has now emerged as one of the major areas of research interest in the condition and, as Thapar and Rutter discuss (Thapar & Rutter 2020), there have been important implications for understanding the heritability of autism and its diagnostic boundaries. Similarly work on the neuroscience of autism has been significantly advanced as we now understand much more about some important basic aspects of brain functioning in ASD and have seen autism emerge as, in many ways, the prototypic disorder for the study of the social brain (McPartland et al, 2021).…”

mentioning

confidence: 99%

Celebrating 40 years since DSM-III

Volkmar

2021

J Autism Dev Disord

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This special section celebrates the first official recognition of Autism as a diagnostic concept in 1980 in the third edition of the American Psychiatric Association's Diagnostic and Statistical Manual. The articles in this special section note the many areas of significant progress made as well as areas that remain important topics for continued and future research. The official recognition of autism as a diagnostic concept has significantly advanced both clinical work and research.

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Looking Back at the Next 40 Years of ASD Neuroscience Research

Cited by 18 publications

References 277 publications

Neural Effects of Physical Activity and Movement Interventions in Individuals With Developmental Disabilities–A Systematic Review

Neural Effects of Physical Activity and Movement Interventions in Individuals With Developmental Disabilities–A Systematic Review

The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children

Celebrating 40 years since DSM-III

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