Macrophages in wound healing: activation and plasticity

Kim, Sang Yong; Nair, Meera G.

doi:10.1111/imcb.12236

Cited by 307 publications

(223 citation statements)

References 60 publications

(141 reference statements)

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“…In addition, MSCs were reported to suppress the maturation and migration of DCs and so that they could serve immunoregulatory ability by modulating the Ag-presenting function of DCs ( 49 ). By secreting multiple cytokines and growth factors, macrophages were demonstrated to play a key role in both advancing and resolving inflammatory diseases such as cancer, wound healing, and autoimmune diseases ( 50 , 51 ). The regulating effect of MSCs on the phenotypes and functions of macrophages has drawn much attention, since it may be involved in distinct stages of gastric cancer biology ( 52 , 53 ).…”

Section: Msc-mediated Polarization Of Tams Contributes To Gastric Canmentioning

confidence: 99%

Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer

Zheng

2020

Front. Oncol.

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Tumor microenvironment (TME) consisting of distinct cell types including stromal cells and immune cells has recently emerged as a pivotal player in tumor development and progression. Mesenchymal stromal cells (MSCs) and tumor-associated macrophages (TAMs) are two representative cells in the TME with plastic properties. This review will focus on the evolution of phenotypes and functions of either MSCs or TAMs, which is “educated” by the TME, as well as interactions between MSCs and TAMs contributing to the distinct stages of tumor biology in gastric cancer. MSCs exert immunoregulatory effects on macrophages and polarize them toward M2-like TAMs, via cell–cell contact and paracrine or extracellular vesicle (EV) transfer mechanism. In turn, M2-TAMs modulate the transition of “naive” MSCs into tumor-derived MSCs, which possess a more potent pro-tumor role than the parent. Moreover, the cross talk between MSCs and TAMs could contribute to cancer biology by inducing the EMT process, metastasis, immune invasion, and immunotherapy resistance in cancer cells. However, molecular mechanisms underlying interactions between MSCs and TAMs in gastric cancer progression need to be thoroughly elucidated, which may provide attractive targets for making promising novel strategies for gastric cancer therapy.

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Section: Msc-mediated Polarization Of Tams Contributes To Gastric Canmentioning

confidence: 99%

Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer

Zheng

2020

Front. Oncol.

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“…By summarising the results of the above‐mentioned clinical case treatment and in vitro coculture of HaCaT cells with CGF membrane, we propose the possible mechanisms for CGF gel or membrane in treating chronic ulcers as follows: Possible mechanisms that promote the generation of granulation tissue: In the process of producing CGF gel, fractional centrifugation can cause platelets to release their growth factors and cytokines, which can facilitate wound healing The stem cells and monocytes present in the CGF gel can move to the bottom of the wound, proliferate, and differentiate further into macrophages to facilitate wound healing The epithelialisation process is impaired in all types of chronic wounds .…”

Section: Discussionmentioning

confidence: 99%

“…Possible mechanisms that promote the generation of granulation tissue: In the process of producing CGF gel, fractional centrifugation can cause platelets to release their growth factors and cytokines, which can facilitate wound healing The stem cells and monocytes present in the CGF gel can move to the bottom of the wound, proliferate, and differentiate further into macrophages to facilitate wound healing …”

Section: Discussionmentioning

confidence: 99%

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

Kao¹

2019

International Wound Journal

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Treating chronic skin wounds in patients with diabetes, bed sores, or stasis dermatitis is typically a time-consuming and costly process, and the outcome is not always promising. Concentrated growth factor (CGF) obtained from the autologous venous blood of patients via fractional centrifugation is employed for producing a CGF gel or membrane that can be applied to expedite self-regeneration of skin wounds. In this case report, we presented the results from 18 patients with chronic skin wounds treated with a CGF gel or membrane produced from autologous venous blood. Noticeable granulation tissue and regenerated epidermal coverage were observed in 16 patients who received CGF treatment over various time courses, thereby demonstrating the significant therapeutic effects of CGF treatment in overall wound healing. The other two patients with stasis ulcers in their calves failed to respond to the treatment because of the comorbidity of iliac vein thrombosis. In addition, by culturing HaCaT keratinocytes using CGF membrane as the foundation, we observed that HaCaT cells attached to the CGF membrane migrated and proliferated to form an epithelium-like structure. Comprehensively, the clinical results infer that CGF gel can expedite the regeneration of the soft tissue at the wound, whereas CGF membrane may facilitate its marginal re-epithelialisation. The combination of the two can promote autologous regeneration of both deep and superficial wounds effectively and safely.

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“…3A, 3B and 3C). Macrophages play a critical role in the delayed wound healing process in DM mice 15,26 by regulated the in ammation responded. To further con rm whether the anti-in ammation effect of DE was related to macrophage, we detected macrophage accumulation by IHC to evolution the effect of DE treatment on macrophage accumulation.…”

Section: Delay Wound Healing Appeared Following Administration Of Stzmentioning

confidence: 99%

Dendrobium officinale Orchid Extract could improve wound healing in diabetic mice

Zhu¹,

Yu²,

Yang³

et al. 2020

Preprint

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Background In diabetes, delayed wound healing is one of the most prominent clinical manifestations and lacks satisfactory therapeutic schemes. Persistent inflammation impairs the healing process which occurs in the late phase of wound healing in diabetes mellitus (DM) mice. It has been report that dendrobium officinale (DE) could decrease inflammation and the NF-κB signaling pathway plays a critical role in regulated inflammation. The aim of the present study is to detect whether DE attenuated inflammation by NF-κB to accelerate wound healing in diabetes. Methods Mice were induced to diabetes by streptozocin (STZ) for 15 days. Two circular 8-mm full-thickness wounds were created on the back and then received DE treatment for 18 days. The percentage of wound healing, re-epithelialization and collagen deposition were calculation to evaluation the effect of DE on wound healing. The expression levels of interleukin (IL)- 1β and TNF-α in the wound site were determined by WB. Macrophage deposition and the type of macrophage were detected by WB and immunohistochemical staining. In addition, the expression of p65 was detected by WB. Results Herein, we observed that the late wound healing could be improved by dendrobium officinale orchid extract (DE) in streptozotocin (STZ)-induced DM mice. The accumulation of collagen was increased by DE treatment in the skin. We also found that the expression of pro-inflammation cytokines IL-1β, and TNF-α were inhibited by DE treatment in the skin wounds of DM mice. Furthermore, the macrophages accumulation which increased in diabetes wound site, were inhibited by DE treatment in the DM mice wound skin. And the CD163 which is a marker of type 2 macrophage was increased by DE treatment. Moreover, we confirmed that DE could decrease the expression of iNos which is a marker of type 1 macrophage by IHC in the skin wounds. And the levels of p65 and p65 phosphorylation were decreased by DE. Conclusions Wound healing can be improved by DE through NF-κB signaling pathway to attenuated inflammation in STZ-induced diabetic mice.

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Macrophages in wound healing: activation and plasticity

Cited by 307 publications

References 60 publications

Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer

Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer

Use of concentrate growth factors gel or membrane in chronic wound healing: Description of 18 cases

Dendrobium officinale Orchid Extract could improve wound healing in diabetic mice

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