Markers of lutein and zeaxanthin status in two age groups of men and women: dietary intake, serum concentrations, lipid profile and macular pigment optical density

Olmedilla‐Alonso, Begoña; Beltrán-de-Miguel, Beatriz; Santiago, Rocío; Cuadrado-Vives, Carmen

doi:10.1186/1475-2891-13-52

Cited by 50 publications

(109 citation statements)

References 29 publications

(89 reference statements)

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“…It was reported that higher levels of macular pigments were associated with lower risk of AMD 14,15 . The retina itself cannot synthesize macular pigments, and supplementation of lutein and zeaxanthin is the only method to increase the macular pigment level 16 . It has been reported that reduced intake of lutein or zeaxanthin might be associated with an increased risk of AMD 5,17,18 .…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of Macular Pigment Optical Density Measurement by Two-Wavelength Autofluorescence in a Clinical Setting

You

Bartsch

Espina

et al. 2016

Retina

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Purpose Macular pigment, composed of lutein, zeaxanthin, and meso-zeaxanthin, is postulated to protect against age-related macular degeneration (AMD), likely due to filtering blue light and its antioxidant properties. Macular pigment optical density (MPOD) is reported to be associated with macular function evaluated by visual acuity and multifocal electroretinogram. Given the importance of macular pigment, reliable and accurate measurement methods are important. The main purpose of current study is to determine the reproducibility of MPOD measurement by two-wave length auto-fluorescence method using scanning laser ophthalmoscopy. Methods Sixty eight eyes of 39 persons were enrolled in the study, including 11 normal eyes, 16 eyes with wet AMD, 16 eyes with dry AMD, 11 eyes with macular edema due to diabetic mellitus, branch retinal vein occlusion or macular telangiectasia and 14 eyes with tractional maculopathy including vitreomacular traction, epiretinal membrane or macular hole. MPOD was measured with a two-wavelength (488 and 514 nm) auto-fluorescence method with the Spectralis HRA+OCT after pupil dilation. The measurement was repeated for each eye 10 minutes later. The Analysis of variance (ANOVA) and Bland-Altman plot were used to assess the reproducibility between the two measurements. Results The mean MPOD at eccentricities of 1° and 2° was 0.36±0.17 (range: 0.04–0.69) and 0.15±0.08(range: −0.03, 0.35) for the first measurement and 0.35±0.17 (range: 0.02, 0.68) and 0.15±0.08 (range: −0.01, 0.33) for the second measurement respectively. The difference between the two measurements was not statistically significant, and the Bland-Altman plot showed 7.4% and 5.9% points outside the 95% limits of agreement, indicating an overall excellent reproducibility. Similarly, there is no significant difference between the first and second measurements of MPOD volume within eccentricities of 1°, 2° and 6° radius, and the Bland-Altman plot showed 8.8%, 2.9% and 4.4% points outside the 95% limits of agreement respectively. The data for the reproducibility did not differ significantly among the various disease and normal eyes. Conclusion Under routine examination conditions with pupil dilation, MPOD measurement by two-wave length auto-fluorescence method showed a high reproducibility.

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Section: Discussionmentioning

confidence: 99%

Reproducibility of Macular Pigment Optical Density Measurement by Two-Wavelength Autofluorescence in a Clinical Setting

You

Bartsch

Espina

et al. 2016

Retina

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“…Despite evidence that supplementation with L+Z successfully increases both the L+Z serum concentration and MPOD,10,11 it is still being debated whether there is an association between MPOD and serum L+Z 12–15. Some observational studies using heterochromatic flicker photometry (HFP) have suggested a positive correlation between L+Z serum concentrations and MPOD 13,16,17. HFP is a psychophysical method to estimate MPOD, which involves “subjective matching” of a flicker target with alternating blue and green light stimuli.…”

Section: Introductionmentioning

confidence: 99%

Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density

Fujimura¹,

Ueda²,

Nomura³

et al. 2016

OPTH

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PurposeTo assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD.MethodsTwenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA. The best-corrected visual acuity and contrast sensitivity (CS) were measured at baseline and at 1, 3, and 6 months. Serum L+Z concentrations were measured at baseline and at 3 months. MPOD was calculated at each time point using fundus autofluorescent images.ResultsSerum L+Z concentration was correlated with MPOD at 1°–2° eccentricity at baseline (r=0.63, P=0.003) and 3 months (r=0.53, P=0.015). Serum L+Z concentration increased by a factor of 2.3±1.0 (P<0.0001). At 6 months, MPOD was significantly higher compared to the baseline level at 0°–0.25° (P=0.034) and 0.25°–0.5° (P=0.032) eccentricity. CS improved after 3 or 6 months of L+Z+DHA supplementation (P<0.05).ConclusionJuxtafoveal MPOD was associated with serum L+Z concentration. Foveal MPOD was increased by L+Z+DHA dietary supplementation.

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“…Lutein is a carotenoid with antioxidant, anticarcinogenic and antiinflammatory properties (Vijayapadma et al, 2014). In the field of ophthalmological diseases, it is well known that lutein and zeaxanthin are present in the macula and lens of the human eye (Landrum and Bone, 2001;Olmedilla-Alonso et al, 2014). These carotenoids have a dual ocular function, contributing to the filtration of ultraviolet rays and exerting an antioxidant function against ROS produced by this radiation.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo effects of lutein against cisplatin-induced ototoxicity

Fidalgo

Saldaña²,

Trinidad

et al. 2016

Experimental and Toxicologic Pathology

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Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in: Experimental and Toxicologic Pathology 68.4 (2016): 197-204 A B S T R A C TIntroduction: Cisplatin is a commonly prescribed drug that produces ototoxicity as a side effect. Lutein is a carotenoid with antioxidant and anti-inflammatory properties previously tested for eye, heart and skin diseases but not evaluated to date in ear diseases.Aim: To evaluate the protective effects of lutein on HEI-OC1 auditory cell line and in a Wistar rat model of cisplatin ototoxicity.Materials and Methods: In vitro study: Culture HEI-OC1 cells were exposed to lutein (2.5-100 mM) and to 25 mM cisplatin for 24 h. In vivo study: Twenty eight female Wistar rats were randomized into three groups. Group A (n = 8) received intratympanic lutein (0.03 mL) (1 mg/mL) in the right ear and saline solution in the left one to determine the toxicity of lutein. Group B (n = 8) received also intraperitoneal cisplatin (10 mg/kg) to test the efficacy of lutein against cisplatin ototoxicity. Group C (n = 12) received intratympanic lutein (0.03 mL) (1 mg/mL) to quantify lutein in cochlear fluids (30 min,1 h and 5 days after treatment). Hearing function was evaluated by means of Auditory Steady-State Responses before the procedure and 5 days after (groups A and B). Morphological changes were studied by confocal laser scanning microscopy.Results: In vitro study: Lutein significantly reduced the cisplatin-induced cytotoxicity in the HEI-OC1 cells when they were pre-treated with lutein concentrations of 60 and 80 mM. In vivo study: Intratympaniclutein (1 mg/mL) application showed no ototoxic effects. However it did not achieve protective effect against cisplatin-induced ototoxicity in Wistar rats.Conclusions: Although lutein has shown beneficial effects in other pathologies, the present study only obtained protection against cisplatin ototoxicity in culture cells, but not in the in vivo model. The large molecule size, the low dose administered, and restriction to diffusion in the inner ear could account for this negative result

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Markers of lutein and zeaxanthin status in two age groups of men and women: dietary intake, serum concentrations, lipid profile and macular pigment optical density

Cited by 50 publications

References 29 publications

Reproducibility of Macular Pigment Optical Density Measurement by Two-Wavelength Autofluorescence in a Clinical Setting

Reproducibility of Macular Pigment Optical Density Measurement by Two-Wavelength Autofluorescence in a Clinical Setting

Preliminary analysis of the relationship between serum lutein and zeaxanthin levels and macular pigment optical density

In vitro and in vivo effects of lutein against cisplatin-induced ototoxicity

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