Microperimetry – A New Tool for Assessing Retinal Sensitivity in Macular Diseases

Laishram, Memota; Srikanth, Krishnamoorthy; Rajalakshmi, A R; Nagarajan, Swathi; Ezhumalai, G

doi:10.7860/jcdr/2017/25799.10213

Cited by 29 publications

(41 citation statements)

References 21 publications

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“…The number of MA in the central area were counted as described. 12 The outer ring of the ETDRS circle of 6 mm centered on the fovea of the OCT thickness map was marked with the Photoshop program. These OCT images and the FA images obtained at the same time were merged.…”

Section: Counting Number Of Masmentioning

confidence: 99%

Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Ichio

Sugimoto

Matsubara

et al. 2020

Trans. Vis. Sci. Tech.

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Section: Counting Number Of Masmentioning

confidence: 99%

Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Ichio

Sugimoto

Matsubara

et al. 2020

Trans. Vis. Sci. Tech.

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“…The fovea is densely populated with 3 types of cones that are responsible for central visual function. Cone function is evaluated subjectively with visual acuity testing(1, 2), color and contrast testing (3,4), and microperimetry (5). All conventional tests of visual function use visible light and their results are altered by ocular media opacities such as cataracts, corneal scars, and dense vitreous debris.…”

Section: Introductionmentioning

confidence: 99%

“…CCT is an adaptive computer-based program that quantifies the severity and type of color vision deficiency (CVD) (3,4) by selectively stimulating L-cones, M-cones, and S-cones. Microperimetry is a retinal sensitivity assay that provides quantitative retinal sensitivity data for both central and peripheral microscopic foci in the retina (5). This data is superimposable on real-time fundus images to correlate abnormalities in retinal structure with function.…”

Section: Introductionmentioning

confidence: 99%

Two-Photon Microperimetry: A media opacity-independent retinal function assay

Wei

Mehta

Palczewska

et al. 2020

Preprint

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Humans perceive light in the visible portion of electromagnetic radiation. However, visible light is scattered and attenuated by optical media opacities. Because all conventional visual function tests rely on visible light, test results are reduced in patients with optical media opacities like corneal scars, cataracts, and vitreous hemorrhages. Infrared (IR) light has greater penetrance through tissue than visible light. Two-photon IR visual stimulation, a recently pioneered technology, should enable testing of retinal visual function and produce results that are less susceptible to media opacities. The effects of simulated media opacities on visual performance in young healthy volunteers and the change in visual function in healthy phakic patients of two age ranges (20-40 and 60-80-year-old) were studied using conventional testing and 2-photon infrared visual stimulation. All subjects completed visual function testing using cone contrast threshold (CCT) testing, conventional microperimetry, visible light microperimetry from a novel device (2PM-Vis), and infrared 2-photon microperimetry (2PM-IR). Retinal sensitivity measured by 2PM-IR demonstrated lower variability than all other devices relying on visible spectrum stimuli. Retinal sensitivity decreased proportionally with the transmittance of light through each filter. CCT scores and retinal sensitivity decreased with age in all testing modalities. Visible spectrum testing modalities demonstrated larger test result differences between young and old patient cohorts; this difference was inversely proportional to the wavelength of the visual function test. 2PM-IR mitigates media opacities which may mask small differences in retinal sensitivity when tested with conventional visual function testing devices.One Sentence SummaryTwo photon infrared visual function testing produces results that are less susceptible to media opacities than conventional tests.

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“…Age-related macular degeneration (AMD) is the leading cause of vision loss in the developed world [1]. The disease impacts vision-related quality of life, as well as having a substantial medical cost [2][3][4][5]. In clinical practice, monitoring of AMD is most often reliant on visual acuity and optical coherence tomography (OCT) even though it is known that both these measures have a relatively weak correlation with measures of patient self-reporting such as the Visual Function Questionnaire (VFQ) [3,6].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Macular Sensitivity Measures and Visual Acuity to Vision-related Quality of Life in Patients with Age-related Macular Degeneration

Forshaw

Parpounas

Sørensen

2020

Preprint

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Background: Visual acuity is commonly used as a functional outcome measure in patients with age-related macular degeneration (AMD), despite having a weak correlation with self-perceived visual quality of life. Microperimetry is a useful method of detecting loss of macular function. We wanted to investigate the relationship between these two objective visual outcome measures and subjective vision-related quality of life, finding out which objective measure is more patient-relevant. Methods: Fifty-six consecutive patients with AMD were recruited to the study. Participants were required to complete the Visual Function Questionnaire 39, the Early Treatment Diabetic Retinopathy Study visual acuity examination and a microperimetry assessment using the Micro Perimeter 3. One patient withdrew consent and seven patients dropped out due to cooperation difficulties under microperimetry. Forty-eight patients with AMD were included in the study: thirty-three patients with late AMD (exudative AMD and/or geographic atrophy) and fifteen patients with early (non-exudative) AMD. The right eye was included as standard, as was the eye with the best-corrected visual acuity.Results: There was a higher correlation between vision-related quality of life and macular sensitivity (rho=0.371; p=0.034) than between vision-related quality of life and visual acuity (rho=0.334; p=0.058) in patients with late AMD. These correlations were not statistically significant in patients with early AMD. Composite score (rho=0.405; p=0.019) and near-distance activities score (rho=0.469; p=0.006) correlated highest with the nasal inner macular sub-region in patients with late AMD. Correlations between composite score and macular sub-regions in patients with early AMD were not significant, but near-distance activities score correlated highest with the nasal outer macular sub-region in these patients (rho=0.735; p=0.002). Conclusions: Macular sensitivity as measured using microperimetry correlates significantly better with vision-related quality of life than visual acuity, showing it to be a more patient-relevant outcome measure in patients with late AMD. Furthermore, the nasal sub-regions of the macula appear to be preferred retinal loci in patients with AMD.(330 words)

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Microperimetry – A New Tool for Assessing Retinal Sensitivity in Macular Diseases

Abstract: This study shows that microperimetry can be a useful tool for objective evaluation of macular function and progression of the disease.

Cited by 29 publications

References 21 publications

Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Two-Photon Microperimetry: A media opacity-independent retinal function assay

Correlation of Macular Sensitivity Measures and Visual Acuity to Vision-related Quality of Life in Patients with Age-related Macular Degeneration

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