Molecular genetics of personality

Noblett, Kurtis L.; Coccaro, Emil F.

doi:10.1007/s11920-005-0028-1

Cited by 40 publications

(16 citation statements)

References 88 publications

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“…For example, with patients as with non ill relatives, it would be of interest to trace the influence of family history or the role of inheritance in clinical subgroups. We considered this high quotient to have a potential value for diagnosis, or as a marker, such as in studies on how mutations of some genes (i.e., neuroligine and neurexine) [1], can alter the balance between exciting and inhibiting transmission, or in studies on the relation of certain genetic polymorphisms with certain personality features [51].…”

Section: Discussionmentioning

confidence: 99%

GABA and Homovanillic Acid in the Plasma of Schizophrenic and Bipolar I Patients

Arrúe¹,

Dávila²,

Zumárraga³

et al. 2009

Neurochem Res

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We have determined the plasma (p) concentration of gamma-aminobutyric acid (GABA) and the dopamine metabolite homovanillic acid (HVA), and the pHVA/pGABA ratio in schizophrenic and bipolar patients. The research was undertaken in a geographic area with an ethnically homogeneous population. The HVA plasma concentrations were significantly elevated in the schizophrenic patients compared to the bipolar patients. The levels of pGABA was significantly lower in the two groups of patients compared to the control group, while the pHVA/pGABA ratio was significantly greater in the both groups of patients compared to the controls. As the levels of pHVA and pGABA are partially under genetic control it is better to compare their concentrations within an homogeneous population. The values of the ratio pHVA/pGABA are compatible with the idea of an abnormal dopamine-GABA interaction in schizophrenic and bipolar patients. The pHVA/pGABA ratio may be a good peripheral marker in psychiatric research.

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Section: Discussionmentioning

confidence: 99%

GABA and Homovanillic Acid in the Plasma of Schizophrenic and Bipolar I Patients

Arrúe¹,

Dávila²,

Zumárraga³

et al. 2009

Neurochem Res

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“…SERT is an extremely important regulator of nervous system activity and is thus a very popular target for pharmaceutical efforts in biomedicine [Owens and Nemeroff, 1998;Schloss and Williams, 1998;Bartlett et al, 2005;Noblett and Coccaro, 2005]; this work has led to the development of a number of selective serotonin reuptake inhibitors, of which Prozac is a leading example [Wong et al, 1995]. Interestingly, SERT function has also been implicated in embryonic morphogenesis [Shuey et al, 1992;Persico et al, 2000Persico et al, , 2001Gaspar et al, 2003] and the regulation of cell proliferation [Eddahibi et al, 2001;Sari and Zhou, 2003].…”

Section: Introductionmentioning

confidence: 99%

Serotonin Transporter Function Is an Early Step in Left-Right Patterning in Chick and Frog Embryos

Fukumoto

Blakely²,

Levin³

2005

Dev Neurosci

108

101

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The neurotransmitter serotonin has been shown to regulate a number of embryonic patterning events in addition to its crucial role in the nervous system. Here, we examine the role of two serotonin transporters, the plasma membrane serotonin transporter (SERT) and the vesicular monoamine transporter (VMAT), in embryonic left-right asymmetry. Pharmacological or genetic inhibitors of either SERT or VMAT specifically randomized the laterality of the heart and viscera in Xenopus embryos. This effect takes place during cleavage stages, and is upstream of the left-sided gene XNR-1. Targeted microinjection of an SERT-dominant negative construct confirmed the necessity for SERT function in embryonic laterality and revealed that the descendants of the right ventral blastomere are the most dependant upon SERT signaling in left-right patterning. Moreover, the importance of SERT and VMAT in laterality is conserved in chick embryos, being upstream of the early left-sided gene Shh. Endogenous transcripts of SERT and VMAT are expressed from the initiation of the primitive streak in chick and are asymmetrically expressed in Hensen’s node. Taken together our data characterize two new right-sided markers in chick gastrulation, identify a novel, early component of the left-right pathway in two vertebrate species, and reveal a new biological role for serotonin transport.

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“…Temperament traits, which are predominantly stable throughout life and not markedly influenced by the environment, are the most heritable component of personality and have been associated with neurotransmitter systems [2,7] . Several studies have been performed with the aim of detecting gene variants associated with specific temperament traits, but results have been conflicting [8][9][10][11] . The relationship between the dopaminergic system and temperament traits has been proposed and thoroughly studied through gene variants in the dopamine receptors [9,10,12,13] ; never-theless, results have not always been reproducible [14,15] and other genes in the dopaminergic system should be considered.…”

Section: Introductionmentioning

confidence: 99%

Tyrosine Hydroxylase and DOPA Decarboxylase Gene Variants in Personality Traits

et al. 2009

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Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question.

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Molecular genetics of personality

Cited by 40 publications

References 88 publications

GABA and Homovanillic Acid in the Plasma of Schizophrenic and Bipolar I Patients

GABA and Homovanillic Acid in the Plasma of Schizophrenic and Bipolar I Patients

Serotonin Transporter Function Is an Early Step in Left-Right Patterning in Chick and Frog Embryos

Tyrosine Hydroxylase and DOPA Decarboxylase Gene Variants in Personality Traits

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