Multiple Self-Healing Indeterminate Cell Lesions of the Skin in an Adult

Contreras, Freddy; Fonseca, Eduardo; Gamallo, C.; Burgos, Eva Manuela Pena

doi:10.1097/00000372-199008000-00011

Cited by 36 publications

(35 citation statements)

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“…5,16,18,20,24 In summary, these cells display similar histologic and antigenic features to LC. Ultrastructurally, however, they differ in that Birbeck granules are absent.…”

Section: Histopathologic Immunohistochemical and Ultrastructural Fimentioning

confidence: 80%

“…Two clinical subtypes seem to predominate: a solitary nodular form [11][12][13][14]16 (Fig 1, A) and a multiple papulonodular form 3,5,6,[8][9][10]15,[17][18][19][20][21][22][23][24][25][26] (Fig 1, B). The former is usually characterized by a single, soft red asymptomatic nodule about 1 cm in diameter; the latter presents with a widespread eruption of multiple, firm asymptomatic lesions ranging in size from a few millimeters to 1 cm, varying in color from dark red to brownish and covered by intact skin.…”

Section: Clinical Findingsmentioning

confidence: 99%

“…Ultrastructurally, however, they differ in that Birbeck granules are absent. 12,18,20,24 Course and prognosis…”

Section: Histopathologic Immunohistochemical and Ultrastructural Fimentioning

confidence: 99%

“…On the other hand, 24 cases with widespread cutaneous lesions have been described, 3,5,6,[8][9][10]15,[17][18][19][20][21][22][23][24][25][26] the majority of which having an indolent or selflimited course; indeed, in a number of reported cases treatment and follow-up were not stated. 3 Table I.…”

Section: Histopathologic Immunohistochemical and Ultrastructural Fimentioning

confidence: 99%

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Unusual variants of non-Langerhans cell histiocytoses

Caputo¹,

Marzano²,

Passoni³

et al. 2007

Journal of the American Academy of Dermatology

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Histiocytic syndromes represent a large, heterogeneous group of diseases resulting from proliferation of histiocytes. In addition to the classic variants, the subset of non-Langerhans cell histiocytoses comprises rare entities that have more recently been described. These last include both forms that affect only the skin or the skin and mucous membranes, and usually show a benign clinical behavior, and forms involving also internal organs, which may follow an aggressive course. The goal of this review is to outline the clinical, histologic, and ultrastructural features and the course, prognosis, and management of these unusual histiocytic syndromes.

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“…5,16,18,20,24 In summary, these cells display similar histologic and antigenic features to LC. Ultrastructurally, however, they differ in that Birbeck granules are absent.…”

Section: Histopathologic Immunohistochemical and Ultrastructural Fimentioning

confidence: 80%

Section: Clinical Findingsmentioning

confidence: 99%

“…Ultrastructurally, however, they differ in that Birbeck granules are absent. 12,18,20,24 Course and prognosis…”

Section: Histopathologic Immunohistochemical and Ultrastructural Fimentioning

confidence: 99%

Section: Histopathologic Immunohistochemical and Ultrastructural Fimentioning

confidence: 99%

See 2 more Smart Citations

Unusual variants of non-Langerhans cell histiocytoses

Caputo¹,

Marzano²,

Passoni³

et al. 2007

Journal of the American Academy of Dermatology

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“…1 These 2 diagnoses are mainly differentiated by the expression of langerin (CD207), which is a surrogate marker for Birbeck granules. 1,3,4,7 In our patient, the lack of expression of langerin in the cutaneous infiltrate together with the expression of CD1a, raised consideration to a diagnosis of ICH over LCH. The lack of expression of S100 protein on skin biopsy is the primary factor that separates this presentation from typical ICH.…”

Section: Discussionmentioning

confidence: 73%

S100-Negative, CD1a-Positive Cutaneous Histiocytosis in a Patient with S100-Positive, CD1a-Positive Pulmonary Histiocytosis

Mask-Bull

Crowson

John

et al. 2015

The American Journal of Dermatopathology

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In the diagnostic approach to histiocytic proliferations, immunohistochemistry may be a source of both confusion and clarification. We present a case of a 60-year-old man with a generalized pruritic eruption that demonstrated positive staining for CD1a, but negative staining for langerin and S100 protein. This immunophenotype is neither representative nor characteristic of any recognized dendritic cell tumor but has been previously described in 3 cases of skin-limited histiocytosis. However, our patient also demonstrated pulmonary histiocytic infiltrates that were positive for both CD1a and S100 proteins. This differing expression of S100 protein witnessed in 2 separate organ systems affords us insight into the pathophysiology of these histiocytic proliferations.

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Novel Histiocytoses Considered in the Context of Histiocyte Subset Differentiation

Wood¹

1993

Arch Dermatol

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Multiple Self-Healing Indeterminate Cell Lesions of the Skin in an Adult

Cited by 36 publications

References 0 publications

Unusual variants of non-Langerhans cell histiocytoses

Unusual variants of non-Langerhans cell histiocytoses

S100-Negative, CD1a-Positive Cutaneous Histiocytosis in a Patient with S100-Positive, CD1a-Positive Pulmonary Histiocytosis

Novel Histiocytoses Considered in the Context of Histiocyte Subset Differentiation

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