Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption

An, Jing; Hao, Dingjun; Zhang, Qian; Chen, Bin; Zhang, Rui; Wang, Yi; Yang, Hao

doi:10.1016/j.intimp.2016.04.024

Cited by 103 publications

(88 citation statements)

References 120 publications

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“…In the human body, polyphenols are antioxidants, and have diverse biological properties such as anti-diabetic [7,8], anticancer [9,10], anti-inflammatory [11,12], cardioprotective [13], osteoprotective [14,15], neuroprotective [16,17], antiasthmatic [18], antihypertensive [19], antiageing [20], antiseptic [21], cerebrovascular protection [22], cholesterol lowering [23], hepatoprotective [24], antifungal [25], antibacterial [26] and antiviral properties [27] (Figure 1). …”

Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Ganesan

2017

Nutrients

228

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Polyphenols are plant secondary metabolites containing antioxidant properties, which help to protect chronic diseases from free radical damage. Dietary polyphenols are the subject of enhancing scientific interest due to their possible beneficial effects on human health. In the last two decades, there has been more interest in the potential health benefits of dietary polyphenols as antioxidant. Black soybeans (Glycine max L. Merr) are merely a black variety of soybean containing a variety of phytochemicals. These phytochemicals in black soybean (BSB) are potentially effective in human health, including cancer, diabetes, cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases. Taking into account exploratory study, the present review aims to provide up-to-date data on health benefit of BSB, which helps to explore their therapeutic values for future clinical settings. All data of in vitro and in vivo studies of BSB and its impact on human health were collected from a library database and electronic search (Science Direct, PubMed, and Google Scholar). The different pharmacological information was gathered and orchestrated in a suitable spot on the paper.

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Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Ganesan

2017

Nutrients

228

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“…Natural products are considered best healers for treatment of bone erosive diseases. These affect the mechanism of osteoclastogenesis and bone resorption [76]. Boneresorbing is done by osteoclasts the multinucleated cells, which are differentiated from hemopoietic progenitors of the monocyte/ macrophage lineage.…”

Section: Natural Products As Bone Healersmentioning

confidence: 99%

Role of Calcium Bio-Minerals in Regenerative Medicine and Tissue Engineering

Upadhyay¹

2017

JSRT

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Present review article emphasize role of biominerals in regenerative medicine and tissue engineering. Among all biominerals calcium is essential for body growth and development. It also performs many fundamental functions in cellular metabolism. Inside cell organic matrix is calcified by calcium phosphate minerals. It also embeds bone cells which participate in the maintenance and organization of bone. This article also emphasizes use of hydroxyapatite a natural mineral used as a bone-building supplement with superior absorption in comparison to calcium. It also explains use of scaffolds that mimic the structure and composition of bone tissue and cells. It also signifies use of HAc microparticles or microparticles loaded with PL, superparamagnetic iron oxide nanoparticles, composite scaffolds of nano-hydroxyapatite (nHAp) and silk fibroin (SF) in bone regeneration mainly in osteoregenerative therapy. For better and successful bone regeneration there is a need to develop low cost sintered hydroxyfluorapatite discs to support cellular proliferation and colonization, tailored mineralization, cell and drug delivery. All adhesion components should show low immunoreactivity and high biocompatibility with natural bone tissues. There is an essential need to make new biocompatible materials for scaffolding, biomeinerals and cementing formulations for regeneration of bones, craniomaxillofacial, dental and orthopedic surgery.

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“…As a consequence, the transcription of nuclear factor of activated T cells cl (NFATc1) and c‐Fos are initiated that may regulate the expression of OC marker genes, such as V‐ATPase d2, tartrate‐resistant acid phosphatase (TRAP), dendritic cell‐specific transmembrane protein (DC‐STAMP), cathepsin K (CTSK), and NFATc1 itself, finally leading to OCs formation and activation. Therefore, RANKL‐induced signaling pathways are the therapeutical targets for abnormal osteolysis …”

Section: Introductionmentioning

confidence: 99%

Ligustilide suppresses RANKL‐induced osteoclastogenesis and bone resorption via inhibition of RANK expression

Wang

Feng

et al. 2019

J of Cellular Biochemistry

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Osteoclast (OC) is the only cell involved in bone resorption. Dysfunction of OCs leads to a variety of bone diseases. Ligustilide (LIG) is the main component of the volatile oil isolated and purified from Angelica sinensis. LIG exerts many pharmacological activities, but its effects on osteoclastogenesis and bone resorption are still unclear. Our study showed that LIG inhibited receptor activator of nuclear factor‐κB (NF‐κB) ligand‐induced OC formation and activation in a dose‐dependent manner. Additionally, LIG downregulated the messenger RNA (mRNA) expression of OC‐specific genes, such as V‐ATPase d2, tartrate‐resistant acid phosphatase, a dendritic cell‐specific transmembrane protein, cathepsin K, and nuclear factor of activated T cells cl. Furthermore, LIG blocked the activation of NF‐κB/extracellular signal‐regulated kinase/p38/immunoreceptor tyrosine‐based activation motif signaling pathways. Crucially, the expression of tumor necrosis factor receptor‐associated factor 6 proteins and the expression of receptor activator of NF‐κB mRNA were inhibited by LIG. However, LIG did not affect the formation and mineralization of osteoblasts. Collectively, this observation suggests that LIG may serve as a promising agent for the prevention and treatment of diseases caused by abnormal bone resorption.

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Natural products for treatment of bone erosive diseases: The effects and mechanisms on inhibiting osteoclastogenesis and bone resorption

Cited by 103 publications

References 120 publications

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Role of Calcium Bio-Minerals in Regenerative Medicine and Tissue Engineering

Ligustilide suppresses RANKL‐induced osteoclastogenesis and bone resorption via inhibition of RANK expression

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