Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults

Villringer, Arno; Planck, J.; Höck, Christoph; Schleinkofer, L.; Dirnagl, Ulrich

doi:10.1016/0304-3940(93)90181-j

Cited by 965 publications

(531 citation statements)

References 21 publications

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“…In contrast to the recorded behavioural data, the fNIRS data of the present study showed that Hence it can be assumed that brain activity was reduced at the site of measurement [46]. This contrasts previous studies that found frontal brain activation in response to more negative stimuli [12,19].…”

Section: Discussioncontrasting

confidence: 99%

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Vögeli¹,

Wolf²,

Wechsler

et al. 2015

Behavioural Brain Research

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Mood, as a long-term affective state, is thought to modulate short-term emotional reactions in animals, but the details of this interplay have hardly been investigated experimentally. Apart from a basic interest in this affective system, mood is likely to have an important impact on animal welfare, as bad mood may taint all emotional experience. In the present study about mood -emotion interaction, 29 sheep were kept under predictable, stimulus-rich or unpredictable, stimulus-poor housing conditions, to induce different mood states. In an experiment, the animals were confronted with video sequences of social interactions of conspecifics showing agonistic interactions, ruminating or tolerantly co-feeding as stimuli of different valences. Emotional reactions were assessed by measuring frontal brain activity using functional near-infrared spectroscopy and by recording behavioral reactions. Attentiveness of the sheep decreased from videos showing agonistic interactions toruminating sheep to those displaying co-feeding sheep. Seeing agonistic interactions was also associated with a deactivation of the frontal cortex, specifically in animals living under predictable, stimulus-rich housing conditions. These sheep generally showed less attentiveness and locomotor activity and they had their ears in a forward position less often and in a backward position more often than the sheep from the unpredictable, stimulus-poor conditions. Housing conditions influenced how the sheep behaved, which can either be thought to be mediated by mood or by the animals' previous experience with stimulusrichness in their housing conditions. Frontal cortical activity may not depend on valence only, but also on the perceptual channel through which the stimuli were perceived.

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Section: Discussioncontrasting

confidence: 99%

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Vögeli¹,

Wolf²,

Wechsler

et al. 2015

Behavioural Brain Research

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“…In the same year four research groups published results and demonstrated that it is possible to non-invasively investigate brain activity using fNIRS (Chance et al, 1993;Hoshi and Tamura, 1993;Kato et al, 1993;Villringer et al, 1993). Brain activity leads to an increase in oxygen consumption, which is accompanied by an increase in cerebral blood flow due to neurovascular coupling.…”

Section: Introductionmentioning

confidence: 99%

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Scholkmann¹,

Kleiser²,

Metz³

et al. 2014

NeuroImage

1,406

1,320

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This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy-and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. This year marks the 20th anniversary of functional near-infrared spectroscopy and imaging (fNIRS/fNIRI). As the vast majority of commercial instruments developed until now are based on continuous wave technology, the aim of this publication is to review the current state of instrumentation and methodology of continuous wave fNIRI. For this purpose we provide an overview of the commercially available instruments and address instrumental aspects such as light sources, detectors and sensor arrangements. Methodological aspects, algorithms to calculate the concentrations of oxy-and deoxyhemoglobin and approaches for data analysis are also reviewed. From the single-location measurements of the early years, instrumentation has progressed to imaging initially in two dimensions (topography) and then three (tomography). The methods of analysis have also changed tremendously, from the simple modified Beer-Lambert law to sophisticated image reconstruction and data analysis methods used today. Due to these advances, fNIRI has become a modality that is widely used in neuroscience research and several manufacturers provide commercial instrumentation. It seems likely that fNIRI will become a clinical tool in the foreseeable future, which will enable diagnosis in single subjects. Contents

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“…On the basis of the tight coupling of neuronal activity and oxygen delivery, [O 2 Hb] and [HHb] are considered as indicators of cortical activation (see Hoshi, 2005;Minagawa-Kawai et al, 2008). The fNIRS provides a reliable measure of brain function, as indicated by the linear relationship between hemodynamics measured by fNIRS and neural activity (Villringer et al, 1993), as well as by the correspondence between fNIRS, functional magnetic resonance imaging, and PET measures (Kleinschmidt et al, 1996;Strangman et al, 2002;Toronov et al, 2001;Villringer et al, 1997). These considerations legitimate the use of fNIRS for investigating the effects of the exposure to the RF-EMFs emitted by MPs on cortical oxygenation.…”

Section: Introductionmentioning

confidence: 99%

Acute Mobile Phones Exposure Affects Frontal Cortex Hemodynamics as Evidenced by Functional Near-Infrared Spectroscopy

Curcio

Ferrara

Limongi

et al. 2009

J Cereb Blood Flow Metab

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This study aimed to evaluate by functional near-infrared spectroscopy (fNIRS), the effects induced by an acute exposure (40 mins) to a GSM (Global System for Mobile Communications) signal emitted by a mobile phone (MP) on the oxygenation of the frontal cortex. Eleven healthy volunteers underwent two sessions (Real and Sham exposure) after a crossover, randomized, double-blind paradigm. The whole procedure lasted 60 mins: 10-mins baseline (Bsl), 40-mins (Exposure), and 10-mins recovery (Post-Exp). Together with frontal hemodynamics, heart rate, objective and subjective vigilance, and self-evaluation of subjective symptoms were also assessed. The fNIRS results showed a slight influence of the GSM signal on frontal cortex, with a linear increase in [HHb] as a function of time in the Real exposure condition (F 4,40 = 2.67; P = 0.04). No other measure showed any GSM exposure-dependent changes. These results suggest that fNIRS is a convenient tool for safely and noninvasively investigating the cortical activation in MP exposure experimental settings. Given the short-term effects observed in this study, the results should be confirmed on a larger sample size and using a multichannel instrument that allows the investigation of a wider portion of the frontal cortex.

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Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults

Cited by 965 publications

References 21 publications

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology

Acute Mobile Phones Exposure Affects Frontal Cortex Hemodynamics as Evidenced by Functional Near-Infrared Spectroscopy

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