New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance

Elias, Ivet; Franckhauser, Sylvie; Bosch, Fátima

doi:10.4161/adip.22880

Cited by 76 publications

(82 citation statements)

References 40 publications

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“…Nevertheless, some recent studies suggest its role in energy haemostasis as well as its influence on adipose tissue function. The increased expression of VEGF is thought to protect against insulin resistance and diet-induced obesity [44]. In our study the BDNF levels were significantly higher in the group of children with headaches.…”

Section: Discussionsupporting

confidence: 51%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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A b s t r a c tIntroduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results: Children with headaches had higher BMI z-scores (0.2 vs. -1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

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Section: Discussionsupporting

confidence: 51%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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“…The predefined gene set relationships across loci identified using MAGENTA 20 highlighted signaling pathways involving vascular endothelial growth factor (VEGF), phosphatase and tensin (PTEN) homolog, the insulin receptor, and peroxisome proliferator-activated receptors (Supplementary Table 20). VEGF signaling plays a central, complex role in angiogenesis, insulin resistance, and obesity 21 , and PTEN signaling promotes insulin resistance 22 . Analyses using DEPICT 23 facilitated prioritization of genes at associated loci, analyses of tissue specificity, and enrichment of reconstituted gene sets through integration of association results with expression data, protein-protein interactions, phenotypic data from gene knockout studies in mice, and predefined gene sets.…”

Section: Resultsmentioning

confidence: 99%

New genetic loci link adipose and insulin biology to body fat distribution

Shungin¹,

Winkler²,

Croteau‐Chonka³

et al. 2015

Nature

1,371

1,443

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Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10−8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

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“…VEGF-A overexpression during angiogenesis is able to reduce adipocyte hypertrophy and body mass in obesity 8. In this context, regular exercise has been shown to regulate pro-angiogenic pathways through the induction of HIF-1a, which induces the transcription of VEGF-A 28,29.…”

Section: Discussionmentioning

confidence: 99%

“…A study conducted by Elias et al 8 showed that VEGF-A overexpression can reduce adipocyte hypertrophy and increase capillary density. Despite the importance of estrogen in AT function, little is known about the influence of ovarian hormone deficiency, especially in vasculature 11,12.…”

Section: Introductionmentioning

confidence: 99%

Estrogen deficiency in ovariectomized rats: can resistance training re-establish angiogenesis in visceral adipose tissue?

Gomes-Gatto¹,

Duarte²,

Stotzer³

et al. 2016

Clinics

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OBJECTIVE:The purpose of this study was to investigate the effects of resistance training on angiogenesis markers of visceral adipose tissue in ovariectomized rats.METHOD:Adult Sprague-Dawley female rats were divided into four groups (n=6 per group): sham-sedentary, ovariectomized sedentary, sham-resistance training and ovariectomized resistance training. The rats were allowed to climb a 1.1-m vertical ladder with weights attached to their tails and the weights were progressively increased. Sessions were performed three times per week for 10 weeks. Visceral adipose tissue angiogenesis and morphology were analyzed by histology. VEGF-A mRNA and protein levels were analyzed by real-time PCR and ELISA, respectively.RESULTS:Ovariectomy resulted in higher body mass (p=0.0003), adipocyte hypertrophy (p=0.0003), decreased VEGF-A mRNA (p=0.0004) and protein levels (p=0.0009), and decreased micro-vascular density (p=0.0181) in the visceral adipose tissue of the rats. Resistance training for 10 weeks was not able to attenuate the reduced angiogenesis in the visceral adipose tissue of the ovariectomized rats.CONCLUSION:Our findings indicate that the resistance training program used in this study could not ameliorate low angiogenesis in the visceral adipose tissue of ovariectomized rats.

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New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance

Cited by 76 publications

References 40 publications

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

New genetic loci link adipose and insulin biology to body fat distribution

Estrogen deficiency in ovariectomized rats: can resistance training re-establish angiogenesis in visceral adipose tissue?

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