Obesity

González‐Muniesa, Pedro; Martínez-González, M Á; Hu, Frank B.; Després, Jean‐Pierre; Matsuzawa, Yūji; Loos, Ruth J.F.; Moreno, Luis A.; Bray, George A.; Martínez, J. Alfredo

doi:10.1038/nrdp.2017.34

Cited by 855 publications

(724 citation statements)

References 214 publications

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“…According to data from the National Health and Nutrition Examination Survey (Ogden et al, 2012) obesity in USA reached up to 36% in adult men and women and 17% in children between years 2009–2010 −0. Currently, more than 2 billion people worldwide are overweight or obese (González-Muniesa et al, 2017), and projections predict that the density of obese individuals will keep increasing for the next three decades up to 60% in adult men, 40% in adult women, and 25% in children (CDC Report 2014, http://www.cdc.gov/obesity/data/adult.html). Obesity is also linked to an increased risk of T2D, cardiovascular disease, cancer, and mortality (Hedley et al, 2004).…”

Section: The Threat Of the New Epidemic Of Metabolic Disordersmentioning

confidence: 99%

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

Gómez‐Pinilla

Yang

2018

Progress in Neurobiology

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The surge in meals high in calories has prompted an epidemic of metabolic disorders around the world such that the elevated incidence of obese and diabetic individuals is alarming. New research indicates that metabolic disorders pose a risk for neurological and psychiatric conditions including stroke, Alzheimer’s disease, Huntington’s disease, and depression, all of which have a metabolic component. These relationships are rooted to a dysfunctional interaction between molecular processes that regulate energy metabolism and synaptic plasticity. The strong adaptive force of dietary factors on shaping the brain during evolution can be manipulated to trans form the interaction between cell bioenergetics and epigenome with the aptitude to promote long-lasting brain healthiness. A thorough understanding of the association between the broad action of nutrients and brain fitness requires high level data processing empowered with the capacity to integrate information from a multitude of molecular entities and pathways. Nutritional systems biology is emerging as a viable approach to elucidate the multiple molecular layers involved in information processing in cells, tissues, and organ systems in response to diet. Information about the wide range of cellular and molecular interactions elicited by foods on the brain and cognitive plasticity is crucial for the design of public health initiatives for curtailing the epidemic of metabolic and brain disorders.

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Section: The Threat Of the New Epidemic Of Metabolic Disordersmentioning

confidence: 99%

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

Gómez‐Pinilla

Yang

2018

Progress in Neurobiology

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“…O primeiro deles ocorre entre a concepção e os 24 meses de idade; os outros dois ocorrem durante a idade escolar, sendo o segundo o rebote inicial da obesidade, entre os 6 e 8 anos de idade, e o terceiro durante o ganho de peso associado à adolescência, no início do desenvolvimento púbere [19]. Uma revisão sistemática do grupo Cochrane mostrou que intervenções que combinam mudança de estilo de vida envolvendo intervenção dietética e atividade física, em conjunto com educação para mudança de estilo de vida, são efetivas no combate à obesidade entre crianças e adolescentes [20].…”

Section: Métodosunclassified

Resultados da primeira fase do Programa Esporte e Saúde em Canela, Rio Grande do Sul: avaliação do perfil nutricional

Mundstock¹,

Toledo²,

Oliveira³

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. RESUMOOBJETIVOS: Apresentar os resultados da avaliação nutricional de crianças e adolescentes, como parte de um programa municipal voltado à saúde de escolares. MÉTODOS: Um estudo transversal realizado entre fevereiro e abril de 2017 avaliou o perfil nutricional de pré-escolares e escolares do município de Canela, Rio Grande do Sul. Foram incluídos estudantes da pré-escola ao nono ano das escolas públicas municipais, atendidos pelo Programa Esporte e Saúde em Canela. Para avaliação nutricional foram aferidas a massa corporal e a estatura, sendo o estado nutricional classificado segundo o Escore Z para o índice de massa corporal. RESULTADOS: Foram avaliados 2691 pré-escolares e escolares, sendo 1408 (52,3%) do sexo masculino. A média de idade foi de 9,63±3,1 anos, o peso médio de 38,59±16,4 kg, a altura média de 139±18 cm e o índice de massa corporal médio 18,9±4,3 kg/m 2 . Quanto ao estado nutricional, 44 (1,7%) foram classificados como magreza, 1725 (64,1%) como eutrofia e 922 (34,2%) tinham peso excessivo, sendo sobrepeso 528 (19,6%), obesidade 286 (10,6%) e obesidade grave 108 (4%). CONCLUSÕES: Um número expressivo dos estudantes da rede pública do município de Canela apresentava sobrepeso ou obesidade, o que reforça a necessidade de programas de prevenção e tratamento da obesidade nessa população. O Programa Esporte e Saúde em Canela tem como proposta colocar em prática estratégias de incentivo aos estudantes para a prática de atividade física e alimentação saudável.DESCRITORES: promoção da saúde; programas nacionais de saúde; prevenção primária; saúde da criança; sobrepeso; obesidade. ABSTRACTAIMS: To present the results of the nutritional evaluation of children and adolescents, as part of a municipal program aimed at the health of schoolchildren. METHODS: A cross-sectional study conducted between February and April 2017 evaluated the nutritional profile of preschool children and schoolchildren in the city of Canela, Rio Grande do Sul state, Brazil. Students from pre-school to the ninth grade of the municipal public schools attended by the Sport and Health Program in Canela were included. For nutritional evaluation, body mass and height were measured, and the nutritional status was classified according to the Z score for body mass index. RESULTS: We evaluated 2691 preschoolers and schoolchildren, with 1408 (52.3%) males. The mean age was 9.63±3.1 years, the mean weight was 38.59±16.4 kg, the mean height was 139±18 cm and the mean body mass index was 18.9±4.3 kg/m 2 . Regarding nutritional status, 44 (1.7%) were classified as thinness, 1725 (64.1%) as eutrophic and 922 (34.2%) were overweight, being overweight 528 (19.6%), obesity 286 (10.6%) and severe obesity 108 (4%). CONCLUSIONS: A significant number of students from public schools in the municipality of Canela were overweight ...

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“…The identification of genes that determine obesity susceptibility can provide information on the pathophysiological mechanisms underlying body weight regulation, food intake control and fat distribution, which in turn can lead to new approaches to treatment and prevention [27].…”

Section: Epigenetics In the Etiology Of Obesitymentioning

confidence: 99%

The Role of Epigenetics in the Etiology of Obesity: A Review

Lima¹,

Hayashi²,

Lima³

et al. 2017

J Clin Epigenet

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Obesity is highly prevalent in developed countries and contributes to a substantial burden of morbidity and mortality. Increased adiposity is often accompanied by comorbidities such as insulin resistance, type 2 diabetes, hypercholesterolemia, cardiovascular disease, fatty liver disease, low-grade inflammation, immune disorders, endocrine complications, and sleep apnea, which may require specific dietary and pharmacological interventions. The current obesity epidemic requires a better understanding of the underlying mechanisms through which genetic and epigenetic factors interact to determine metabolic characteristics. Epigenetic studies are dynamic; tags with reversible potential can be influenced by genetics and environment attributing phenotypic variations. There are large knowledge gaps regarding how human epigenetic changes are related to obesity and its consequences. Therefore, the present study elucidates the role of epigenetics in the etiology of obesity. Recent studies suggest that the epigenetic regulation of gene expression (DNA methylation and histone modifications) could be a major contributor to the variation of susceptibility to diseases such as obesity. The identification of genes that determine obesity susceptibility can provide information on the pathophysiological mechanisms underlying body weight regulation, food intake control and fat distribution, which in turn can lead to new approaches to treatment and prevention of obesity.

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Obesity

Cited by 855 publications

References 214 publications

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

System biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

Resultados da primeira fase do Programa Esporte e Saúde em Canela, Rio Grande do Sul: avaliação do perfil nutricional

The Role of Epigenetics in the Etiology of Obesity: A Review

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