Offspring of Depressed Parents: 30 Years Later

Weissman, Myrna M.; Wickramaratne, Priya; Gameroff, Marc J.; Warner, Virginia; Pilowsky, Daniel J.; Kohad, Rajni Gathibandhe; Verdeli, Helena; Skipper, Jamie; Talati, Ardesheer

doi:10.1176/appi.ajp.2016.15101327

Cited by 255 publications

(253 citation statements)

References 61 publications

(24 reference statements)

Supporting

Mentioning

237

Contrasting

Unclassified

Order By: Relevance

“…This report included seventy-three adult participants (43 female) who had EEG recordings at year 30 (T30; mean age 43.25 yrs ± 10.2) as part of a multiwave three-generation longitudinal study of individuals at high and low risk for major depression based on family history (Weissman et al, 1997, 2005, 2006, in press). Twenty-one participants were also included in our previous report of the findings at T20 (Tenke et al, 2013), while the remaining 53 only had EEG data at T30.…”

Section: Methodsmentioning

confidence: 99%

Association of posterior EEG alpha with prioritization of religion or spirituality: A replication and extension at 20-year follow-up

Tenke

Kayser

Svob

et al. 2017

Biological Psychology

Self Cite

View full text Add to dashboard Cite

A prior report (Tenke et al. 2013 Biol. Psychol. 94:426–432) found that participants who rated religion or spirituality (R/S) highly important had greater posterior alpha after 10 years compared to those who did not. Participants who subsequently lowered their rating also had prominent alpha, while those who increased their rating did not. Here we report EEG findings 20 years after initial assessment. Clinical evaluations and R/S ratings were obtained from 73 (52 new) participants in a longitudinal study of family risk for depression. Frequency PCA of current source density transformed EEG concisely quantified posterior alpha. Those who initially rated R/S as highly important had greater alpha compared to those who did not, even if their R/S rating later increased. Furthermore, changes in religious denomination were associated with decreased alpha. Results suggest the possibility of a critical stage in the ontogenesis of R/S that is linked to posterior resting alpha.

show abstract

Section: Methodsmentioning

confidence: 99%

Association of posterior EEG alpha with prioritization of religion or spirituality: A replication and extension at 20-year follow-up

Tenke

Kayser

Svob

et al. 2017

Biological Psychology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Following procedures detailed in Posner et al [8], participants (N=104) aged 11 - 60 years were drawn from Weissman et al’s [9,10] 3-generation, longitudinal study comprising families at high and low risk for MDD. Risk status was defined by MDD status in the probands from Generation 1 (G1).…”

Section: Methodsmentioning

confidence: 99%

Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression

Svob

Wang

Weissman

et al. 2016

Neuroscience Letters

Self Cite

View full text Add to dashboard Cite

Individuals at high risk for depression have increased default mode network (DMN) connectivity, as well as reduced inverse connectivity between the DMN and the central executive network (CEN) (Posner et al., 2015). Other studies have indicated that the belief in the importance of religion/spirituality (R/S) is protective against depression in high risk individuals (Miller et al., 2012). Given these findings, we hypothesized that R/S importance would moderate DMN connectivity, potentially reducing DMN connectivity or increasing DMN-CEN inverse connectivity in individuals at high risk for depression. Using resting-state functional connectivity MRI (rs-fcMRI) in a sample of 104 individuals (aged 11 – 60) at high and low risk for familial depression, we previously reported increased DMN connectivity and reduced DMN-CEN inverse connectivity in high risk individuals. Here, we found that this effect was moderated by self-report measures of R/S importance. Greater R/S importance in the high risk group was associated with decreased DMN connectivity. These results may represent a protective neural adaptation in the DMN of individuals at high risk for depression, and may have implications for other meditation-based therapies for depression.

show abstract

“…2,[4][5][6][7] Even when the onset of depression is in adult life, many of its contributing risk factors begin during childhood, 8,9 highlighting the importance of understanding the etiology of early-onset MDD. 10 The most common major risk factor for early-onset MDD is depression in a parent. 6,[11][12][13] Therefore, the adolescent offspring of depressed parents are an important group for investigating the initial development of early-onset MDD.…”

mentioning

confidence: 99%

Antecedents of New-Onset Major Depressive Disorder in Children and Adolescents at High Familial Risk

et al. 2017

View full text Add to dashboard Cite

General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Copyright 2017 American Medical Association. All rights reserved. Antecedents of New-Onset Major Depressive Disorder in Children and Adolescents at High Familial RiskFrances Rice, PhD; Ruth Sellers, PhD; Gemma Hammerton, PhD; Olga Eyre, MD; Rhys Bevan-Jones, MD; Ajay K. Thapar, PhD, MD; Stephan Collishaw, PhD; Gordon T. Harold, PhD; Anita Thapar, PhD, MD IMPORTANCE Early-onset major depressive disorder (MDD) is common in individuals at high familial risk of depression and is associated with poor long-term mental health, social, and educational outcomes.OBJECTIVES To examine the developmental pathways that lead to first-episode adolescent-onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed model that enables simultaneous testing of different pathways to incident adolescent-onset MDD composed of contributions from familial/genetic and social risk factors, as well as effects via specific clinical antecedents. DESIGN, SETTING, AND PARTICIPANTSThis investigation was a 4-year longitudinal study (April 2007 to March 2011) among offspring of depressed parents in the general community. Analyses were conducted between September 1, 2015, and May 27, 2016. Participants were 337 families in whom the index parent (315 mothers and 22 fathers) had experienced at least 2 episodes of MDD (recruited through primary care) and among whom there was a biologically related child in the age range of 9 to 17 years living with the index parent (197 girls and 140 boys with a mean [SD] age of 12.4 [2.0] years) at baseline. Offspring with MDD before the study or at baseline (n = 27), offspring with an episode of MDD that had remitted by follow-up (n = 4), and offspring with missing baseline MDD data (n = 2) were excluded. Ninety-two percent (279 of 304) of families completed the follow-up. MAIN OUTCOMES AND MEASURESThe primary outcome was new-onset offspring MDD, and the secondary outcome was the total DSM-IV MDD symptom score. RESULTSOn average, children and adolescents had a mean (SD) of 1.85 (1.74) (range, 0-8.5) DSM-IV symptoms of MDD at follow-up. Twenty (6 males and 14 females) had new-onset MDD, with a mean (SD) age at onset of 14.4 (2.0) years (range, 10-18 years). Irritability (β = 0.12, P = .03) and fear and/or anxiety (β = 0.38, P < .001) were significant independent clinical antecedents of new adolescent-onset MDD, but disruptive behavior (β = −0.08, P = .14) and low mood (β = −0.03, P = .65) were not. The results were similar for the DSM-IV symptom count at follow-up. All the measured familial/genetic and social risk indicators directly influenced risk for new-onset MDD rather than indirectly through acting on dimensional clinical antecedents.CONCLUSIONS AND RELEVANCE There are multiple pathways to first-onset adolescent depression in individuals at fam...

show abstract

Offspring of Depressed Parents: 30 Years Later

Cited by 255 publications

References 61 publications

Association of posterior EEG alpha with prioritization of religion or spirituality: A replication and extension at 20-year follow-up

Association of posterior EEG alpha with prioritization of religion or spirituality: A replication and extension at 20-year follow-up

Religious and spiritual importance moderate relation between default mode network connectivity and familial risk for depression

Antecedents of New-Onset Major Depressive Disorder in Children and Adolescents at High Familial Risk

Contact Info

Product

Resources

About