Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow

Abstract

Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis.

Effect of Feeding on Olive Oil and Thyme on Pregnancy and Lactation Periods

“…An experimental model showed that bone remodeling was more pronounced in laboratory animals which had been treated with a paly phenol diet [7]. A possible influence of olive oil on bone mass inteance and osteoporosis prevention, its results showed that women on a Mediterranean diet rich in olive oil had better bone density levels than those on a standard diet [32].…”

“…Increase cancer, stroke and coronary heart disease risks associated with long term use of postmenopausal hormone therapy (HT) have rapidly declined the number of women treated with HT either estrogen alone or estrogen plus progesterone [6]. An experimental model showed that bone remodeling was more pronounced in laboratory animals which had been treated with a polyphenols-rich diet [7]. According, [8] reported that the high quality of olive oil reduces low density lipoprotein cholesterol (LDL), peroxidation to significant higher extent than sunflower oil in hypercholesterolemia postmenopausal women.…”

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

“…Some epidemiological studies showed correlation between olive products consumption and incidence of breast cancer. Due to its little mild side effects, oleuropein is required as one of the phenolic compounds in olive with a powerful effect on inhibiting the proliferation and migration of cancer cells (Sirianni et al, 2010;Santiago-Mora et al, 2011). Oleuropein can also target steps in cancer progression (Abe et al, 2011).…”

Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma

“…Purified oleuropein considerably reduced the infarct size in both normal and hypercholesterolemic rabbits that were subjected to ischemia/reperfusion, protected the reperfused myocardium from the oxidative damage and decreased total cholesterol and triglyceride levels (Andreadou et al 2006). In vitro, oleuropein reduced the expression of PPARc, inhibited adipogenesis and enhanced osteoblastogenesis in stem cells derived from human bone marrow (Santiago-Mora et al 2011). Oleuropein (in concentration higher than 100 lM) acted on 3T3-L1 cells to reduce preadipocyte differentiation and lipid accumulation and thus regulated the size of fat cells.…”