Overview of Dietary Influences on Atherosclerotic Vascular Disease:Epidemiology and Prevention

Thomas, G. Neil; Cheung, Bmy; Ho, Sai Yin; Macfarlane, Duncan J.; Deng, Han Bing; McGhee, Sarah M.; Woo, Jean; Lam, Tai Hing; Tomlinson, Brian

doi:10.2174/187152907780830897

Cited by 4 publications

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“…What is the time-effect relation of blood pressure lowering by lactotripeptides? Trials in hypertensive subjects, in which BP measurements were taken at relatively early time-points, demonstrated significantly lower SBP values (8)(9)(10) and DBP values (6-7 mmHg) after 1-2 weeks of active treatment compared with placebo treatment (22 -25) . Aihara et al (25) reported a trend for a BP-lowering effect even after 1 d of treatment with the peptides compared with placebo, but it took another week for the effects to reach significance.…”

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confidence: 98%

Lactotripeptides and antihypertensive effects: a critical review

Boelsma¹,

Kloek

2008

Br J Nutr

103

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Hypertension or high blood pressure is a significant health problem worldwide. Typically, lifestyle changes, including adopting a healthy diet, are recommended for people with an elevated blood pressure. Lactotripeptides are bioactive milk peptides with potential antihypertensive properties in man. These peptides, as part of a food product or as nutraceutical, may contribute to the prevention and treatment of hypertension. This paper reviews the current evidence of the blood pressure control properties of lactotripeptides in man. Blood pressure-lowering effects of lactotripeptides are typically measured after 4 -6 weeks of treatment. However, in some cases, a blood pressure response has been observed after 1 -2 weeks. Maximum blood pressure reductions approximate 13 mmHg (systolic blood pressure) and 8 mmHg (diastolic blood pressure) after active treatment compared with placebo, and are likely reached after 8-12 weeks of treatment. Effective dosages of lactotripeptides range from 3·07 to 52·5 mg/d. Evidence indicates that lactotripeptides are only effective at elevated blood pressure; no further lowering of normal blood pressure has been observed. Concomitant intake of antihypertensive medication does not seem to influence the potency of lactotripeptides to lower blood pressure. Similarly, ethnicity has not been found to influence the extent of lactotripeptide-induced blood pressure lowering. Based on the currently available data, lactotripeptides appear to be safe and effective. Thus, they can be part of a healthy diet and lifestyle to prevent or reduce high blood pressure.Blood pressure: Antihypertensive effects: Lactotripeptides: Milk peptides CVD and its related complications affect a significant proportion of the world's population (1) . The risk of developing CVD is directly related to blood pressure (BP) level. Prolonged reductions of diastolic blood pressure (DBP) of 5, 7·5 and 10 mmHg were respectively associated with at least 34, 46 and 56 % less stroke and at least 21, 29 and 37 % less CHD (2 -4) . In a large meta-analysis by the Prospective Studies Collaboration (5) , it was estimated that a 10 mmHg lower usual systolic blood pressure (SBP) or 5 mmHg lower usual DBP would, in the long term, be associated with about 40 % lower risk of stroke death and about 30 % lower risk of death from IHD or other vascular causes. Extending these observations to small reductions in DBP of about 2 mmHg would result in a 14 % reduction in the risk of stroke, and 6 % reduction in the risk of CHD (6) . Also SBP lower by 2 mmHg is associated with lower IHD and CVD death rates by 4-5 % (7) . The results suggested that for the large majority of individuals, whether hypertensive or normotensive, a lower BP should eventually confer a lower risk of CVD.Adoption of a healthy lifestyle is important for the prevention of high BP and is an indispensable part of the management of hypertension. The application of specific foods or food components in the prevention and/or treatment of disease are of particular relevance in the mana...

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confidence: 98%

Lactotripeptides and antihypertensive effects: a critical review

Boelsma¹,

Kloek

2008

Br J Nutr

103

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Dietary Paradoxes to Optimize Cardiovascular Risk Management in Chronic Kidney Disease

Durvasula

2012

The Kidney in Heart Failure

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Antihypertensive peptides of animal origin: A review

Bhat

Kumar

Bhat

2016

Critical Reviews in Food Science and Nutrition

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Many bioactive peptides trigger certain useful antihypertensive activities in the living body system and there is a mounting worldwide interest in the therapeutic potential of these bioactive peptides for exploitation in vivo against the hypertension. Studies suggest the antihypertensive properties for many bioactive peptides of animal origin with underlying mechanisms ranging from inhibition of angiotensin-converting enzyme to additional mechanisms to lower blood pressure such as opioid-like activities and mineral-binding and antithrombotic properties. Antihypertensive peptides are the most extensively studied of all the bioactivities induced by food protein hydrolysates, highlighting their importance in human health and disease prevention and treatment. There exist enormous opportunities for the production of novel peptide-based products in biopharmaceutical manufacturing industries for the treatment, prevention, and mitigation of hypertension. Numerous products have already struck on the global market and many more are in process. This article focuses on antihypertensive peptides identified in the meat, fish, blood, milk, dairy products, and egg and their probable application as novel ingredients in the development of functional food products as dietary treatment of hypertension.

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Overview of Dietary Influences on Atherosclerotic Vascular Disease:Epidemiology and Prevention

Cited by 4 publications

References 0 publications

Lactotripeptides and antihypertensive effects: a critical review

Lactotripeptides and antihypertensive effects: a critical review

Dietary Paradoxes to Optimize Cardiovascular Risk Management in Chronic Kidney Disease

Antihypertensive peptides of animal origin: A review

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