Photobiomodulation for spinal cord injury: A systematic review and meta-analysis

Ramezani, Fatemeh; Razmgir, Maryam; Tanha, Kiarash; Nasirinezhad, Farinaz; Neshasteh-Riz, Ali; Bahrami-Ahmadi, Amir; Hamblin, Michael R.; Janzadeh, Atousa

doi:10.1016/j.physbeh.2020.112977

Cited by 25 publications

(9 citation statements)

References 17 publications

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“…Complementary therapeutic approaches, including cell therapy [7,8], glial scar digestion, neurotrophic factor delivery, laser therapy [9][10][11], and electrical stimulation of surrounding tissue as well as clinical rehabilitation, are being developed to achieve nerve fiber regeneration and functional restoration in SCI. But the extent of neural tissue destruction in chronic SCI in humans, with entire segments of the spinal cord replaced by fluid-filled cysts, remains a critical concern.…”

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confidence: 99%

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Rahimi

Behroozi

Motamed

et al. 2023

J Mater Sci: Mater Med

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Since the CNS is unable to repair itself via neuronal regeneration in adult mammals, alternative therapies need to be found. The use of cerium oxide nanoparticles to repair nerve damage could be a promising approach for spinal cord reconstruction. In this study, we constructed a scaffold containing cerium oxide nanoparticles (Scaffold-CeO2) and investigated the rate of nerve cell regeneration in a rat model of spinal cord injury. The scaffold of gelatin and polycaprolactone was synthesized, and a gelatin solution containing cerium oxide nanoparticles was attached to the scaffold. For the animal study, 40 male Wistar rats were randomly divided into 4 groups (n = 10): (a) Control; (b) Spinal cord injury (SCI); (c) Scaffold (SCI + scaffold without CeO2 nanoparticles); (d) Scaffold-CeO2 (SCI + scaffold containing CeO2 nanoparticles). After creation of a hemisection SCI, scaffolds were placed at the site of injury in groups c and d, and after 7 weeks the rats were subjected to behavioral tests and then sacrificed for preparation of the spinal cord tissue to measure the expression of G-CSF, Tau and Mag proteins by Western blotting and Iba-1 protein by immunohistochemistry. The result of behavioral tests confirmed motor improvement and pain reduction in the Scaffold-CeO2 group compared to the SCI group. Decreased expression of Iba-1 and higher expression of Tau and Mag in the Scaffold-CeO2 group compared to the SCI group could be the result of nerve regeneration caused by the scaffold containing CeONPs as well as relief of pain symptoms. Graphical Abstract

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confidence: 99%

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Rahimi

Behroozi

Motamed

et al. 2023

J Mater Sci: Mater Med

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“…PBMT has been used in pain management for years. Many studies have indicated that PBMT has analgesic and anti-in ammatory effects in both experimental and clinical trials (20)(21)(22). Our previous study has also demonstrated the effectiveness of PBMT in NP, as well as a decrease in apoptosis (23)(24)(25)(26).…”

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confidence: 89%

Evaluation of Photobiomodulation Therapy (117 and 90 seconds) on Pain, Regeneration, and Epigenetic Factors (HDAC 2, DNMT3a) Expression Following Spinal Cord Injury in A Rat Model

MotamedNejad

Behroozi

Kookli

et al. 2023

Preprint

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Background Photobiomodulation therapy (PBM), due to its anti-inflammatory, analgesic effects, and most importantly as a non-invasive procedure, has currently gained a special setting in pain relief and the treatment of Spinal cord injuries (SCI). However, the mechanism of action of the PBM is not yet completely understood. Methods In this study, SCI is induced by an aneurysm clip. Adult male rats were divided into 4 groups: Control, SCI, SCI + PBMT 90 seconds, and SCI + PBMT 117 seconds. After 7 weeks, hyperalgesia, allodynia, and functional recovery were assessed. Fibroblasts were counted after H&E staining. The expression of HDAC2, DNMT3a, GAD65, and GFAP after 4 weeks of daily PBMT (90 and 117 s) was probed by western blotting. Results Both PBMTs (90 & 117 seconds) significantly improved the pain and ability to move and fibroblast invasion was reduced. SCI + PBMT 90s, increased GAD65, HDAC2, and DNMT3a expression. However,PBMT 117s decreased GFAP, HDAC2, and DNMT3a. Conclusion PBMT 90 and 117 s improved the pain, and functional recovery equally. Yet, the mechanism of action appears to change with different durations of radiation.

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“…[3,4]. Traumatic SCI often lead to devastating loss of sensory and motor function, and despite therapeutic methods which have shown positive results in the research phase [5][6][7][8][9][10] so far there is no drug treatments that can restore function consistently in affected patients Although there is some spontaneous regenerative responses that occurs following SCI, this is often insufficient for significant improvement [11]. Several factors, including inappropriate immune responses, glial scar development, and lack of adequate neurotrophic support after SCI may be the cause of this lack of regenerative ability [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Sustained delivery of chABC improves functional recovery after a spine injury

et al. 2022

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Introduction Chondroitinase ABC (chABC) is an enzyme could improve regeneration and thereby improving functional recovery of spinal cord injury (SCI) in rodent models. Degradation of the active enzyme and diffusion away from the lesion are the causes of using hydrogels as a scaffold to deliver the chABC into the lesion site. In this meta-analysis, we investigated the effects of chABC embedded in a scaffold or hydrogel on the functional recovery after SCI. Method Databases were searched based on keywords related to chABC and spinal cord injury (SCI). Primary and secondary screening was performed to narrow down study objectives and inclusion criteria, and finally the data were included in the meta-analysis. The standard mean difference of the score of the functional recovery that measured by Basso, Beattie, Bresnahan (BBB) test after SCI was used to analyze the results of the reported studies. Subgroup analysis was performed based on SCI model, severity of SCI, transplantation type, and the follow-up time. Quality control of articles was also specified. Results The results showed that embedding chABC within the scaffold increased significantly the efficiency of functional recovery after SCI in animal models (SMD = 1.95; 95% CI 0.71–3.2; p = 0.002) in 9 studies. SCI model, severity of SCI, injury location, transplantation type, and the follow-up time did not affect the overall results and in all cases scaffold effect could not be ignored. However, due to the small number of studies, this result is not conclusive and more studies are needed. Conclusion The results could pave the way for the use of chABC embedded in the scaffold for the treatment of SCI and show that this method of administration is superior to chABC injection alone.

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Photobiomodulation for spinal cord injury: A systematic review and meta-analysis

Cited by 25 publications

References 17 publications

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Evaluation of Photobiomodulation Therapy (117 and 90 seconds) on Pain, Regeneration, and Epigenetic Factors (HDAC 2, DNMT3a) Expression Following Spinal Cord Injury in A Rat Model

Sustained delivery of chABC improves functional recovery after a spine injury

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