Polarizing the T helper 17 response in<i>Citrobacter rodentium</i>infection via expression of resistin-like molecule α

Chen, Gang; Chan, Alexander J; Chung, Josiah I; Jang, Jessica C.; Osborne, Lisa C.; Nair, Meera G.

doi:10.4161/gmic.29100

Cited by 6 publications

(8 citation statements)

References 33 publications

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“…113 It has been suggested that also RELMα might be involved in Th17 cell polarization. Chen et al 114 showed that leptin suppressed Th2-type cytokine synthesis, that is, IL-5…”

Section: Adipokines Modulate the Activity Of Cells Engaged In Innatmentioning

confidence: 99%

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

2020

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Summary Adipokines are predominantly known to play a vital role in the control of food intake, energy homeostasis and regulation of glucose and lipid metabolism. However, evidence supporting the concept of their extensive involvement in immune system defence mechanisms and inflammatory processes continues to grow. Some of the adipokines, that is, leptin and resistin, have been recognized to exhibit mainly pro‐inflammatory properties, whereas others such as visfatin, chemerin, apelin and vaspin have been found to exert regulatory effects. In contrast, adiponectin or omentin are known for their anti‐inflammatory activities. Hence, adipokines influence the activity of various cells engaged in innate immune response and inflammatory processes mainly by affecting adhesion molecule expression, chemotaxis, apoptosis and phagocytosis, as well as mediators production and release. However, much less is known about the role of adipokines in processes involving lymphoid lineage cells. This review summarizes the current knowledge regarding the importance of different adipokines in the lymphopoiesis, recirculation, differentiation and polarization of lymphoid lineage cells. It also provides insight into the influence of selected adipokines on the activity of those cells in tissues.

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“…113 It has been suggested that also RELMα might be involved in Th17 cell polarization. Chen et al 114 showed that leptin suppressed Th2-type cytokine synthesis, that is, IL-5…”

Section: Adipokines Modulate the Activity Of Cells Engaged In Innatmentioning

confidence: 99%

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

2020

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“…In a mouse model of enteropathogenic/enterohemorrhagic bacterial infection with Citrobacter rodentium , RELMα-mediated suppression of Th2 cytokines led instead to increased Th17 cytokine-driven inflammation in the colon. Surprisingly, RELMα immunostimulatory effect had no significant effect on bacterial clearance suggesting that RELMα expression in Citrobacter rodentium infection was soley detrimental to the host [29, 72].…”

Section: The Long and Winding Road: Relm Function In Mice And Menmentioning

confidence: 99%

Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders

2018

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The Resistin-Like Molecules (RELM) α, β, and γ and their namesake, resistin, share structural and sequence homology but exhibit significant diversity in expression and function within their mammalian host. RELM proteins are expressed in a wide range of diseases, such as: microbial infections (eg. bacterial and helminth), inflammatory diseases (eg. asthma, fibrosis) and metabolic disorders (eg. diabetes). While the expression pattern and molecular regulation of RELM proteins are well characterized, much controversy remains over their proposed functions, with evidence of host-protective and pathogenic roles. Moreover, the receptors for RELM proteins are unclear, although three receptors for resistin, decorin, adenylyl cyclase-associated protein 1 (CAP1), and Toll-like Receptor 4 (TLR4) have recently been proposed. In this review, we will first summarize the molecular regulation of the RELM gene family, including transcription regulation and tissue expression in humans and mouse disease models. Second, we will outline the function and receptor-mediated signaling associated with RELM proteins. Finally, we will discuss recent studies suggesting that, despite early misconceptions that these proteins are pathogenic, RELM proteins have a more nuanced and potentially beneficial role for the host in certain disease settings.

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“…In contrast no direct interaction of RELMa with parasites or parasite products has been described so far and somewhat surprisingly RELMa has instead been associated with suppression of Th2 immune responses and reduced resistance to gastrointestinal parasite infection (59,87). Furthermore RELMa from 'alternatively activated' dendritic cells during the priming of a Th2 response in vitro leads to enhanced IL-10 production from T cells (82) and RELMa has been implicated in the induction of Th17-responses during bacterial infection (94). Thus, one of the main effects of RELMa seems to be the modulation of the adaptive immune response limiting Th2 responses and enhancing Th17-or regulatory responses.…”

Section: Relma/bmentioning

confidence: 99%

Macrophage proliferation, provenance, and plasticity in macroparasite infection

Rückerl

Allen

2014

Immunological Reviews

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Summary:Macrophages have long been center stage in the host response to microbial infection, but only in the past 10–15 years has there been a growing appreciation for their role in helminth infection and the associated type 2 response. Through the actions of the IL-4 receptor α (IL-4Rα), type 2 cytokines result in the accumulation of macrophages with a distinctive activation phenotype. Although our knowledge of IL-4Rα-induced genes is growing rapidly, the specific functions of these macrophages have yet to be established in most disease settings. Understanding the interplay between IL-4Rα-activated macrophages and the other cellular players is confounded by the enormous transcriptional heterogeneity within the macrophage population and by their highly plastic nature. Another level of complexity is added by the new knowledge that tissue macrophages can be derived either from a resident prenatal population or from blood monocyte recruitment and that IL-4 can increase macrophage numbers through proliferative expansion. Here, we review current knowledge on the contribution of macrophages to helminth killing and wound repair, with specific attention paid to distinct cellular origins and plasticity potential.

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Polarizing the T helper 17 response inCitrobacter rodentiuminfection via expression of resistin-like molecule α

Cited by 6 publications

References 33 publications

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders

Macrophage proliferation, provenance, and plasticity in macroparasite infection

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