Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

Poppitt, Sally D.; Keogh, Geraldine F.; Lithander, Fiona E; Wang, Yudong; Mulvey, Tom B.; Chan, Yih-Kai; McArdle, Brian H.; Cooper, Garth J. S.

doi:10.1016/j.nut.2007.12.012

Cited by 97 publications

(106 citation statements)

References 48 publications

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“…We did not find any effects on plasma hs-CRP from a meal rich in medium-chain SFA or MUFA, nor were any differences in hs-CRP responses between REL and CON. This result agrees with the majority of studies on hs-CRP responses to meals high in mixed fat in healthy individuals [14,21,22] and subjects with T2D [22]. While MUFA is found to decrease the hs-CRP response in healthy persons [9], SFA is shown to have an increasing effect on hs-CRP in healthy and type 2 diabetic subjects [8].…”

Section: Discussionsupporting

confidence: 90%

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Acute Effects of Dietary Fat on Inflammatory Markers and Gene Expression in First-Degree Relatives of Type 2 Diabetes Patients

Pietraszek

Gregersen²,

Hermansen³

2011

Rev Diabet Stud

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BACKGROUND: Subjects with type 2 diabetes (T2D) and their relatives (REL) carry an increased risk of cardiovascular disease (CVD). Low-grade inflammation, an independent risk factor for CVD, is modifiable by diet. Subjects with T2D show elevated postprandial inflammatory responses to fatrich meals, while information on postprandial inflammation in REL is sparse. AIM: To clarify whether medium-chain saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) have differential acute effects on low-grade inflammation in REL compared to controls (CON). METHODS: In randomized order, 17 REL and 17 CON ingested two fat-rich meals, with 72 energy percent from MUFA and 79 energy percent from mainly medium-chain SFA, respectively. Plasma high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), adiponectin, and leptin were measured at baseline, 15 min, 60 min, and 240 min postprandially. Muscle and adipose tissue biopsies were taken at baseline and 210 min after the test meal, and expression of selected genes was analyzed. RESULTS: Plasma IL-6 increased (p < 0.001) without difference between REL and CON and between the meals, whereas plasma adiponectin and plasma hs-CRP were unchanged during the 240 min observation period. Plasma leptin decreased slightly in response to medium-chain SFA in both groups, and to MUFA in REL. Several genes were differentially regulated in muscle and adipose tissue of REL and CON. CONCLUSIONS: MUFA and medium-chain SFA elicit similar postprandial circulating inflammatory responses in REL and CON. Medium-chain SFA seems more proinflammatory than MUFA, judged by the gene expression in muscle and adipose tissue of REL and CON.

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Section: Discussionsupporting

confidence: 90%

“…Leptin decreases 0-240 min postprandially [12], but increases subsequently after a fat-rich meal [13]. Also, IL-6 has been found to increase in response to a fat-rich meal [8,14,15].…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of Dietary Fat on Inflammatory Markers and Gene Expression in First-Degree Relatives of Type 2 Diabetes Patients

Pietraszek

Gregersen²,

Hermansen³

2011

Rev Diabet Stud

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“…An acute meal-induced increase in IL-6 and TNF-α is known from previous studies with patients with the metabolic syndrome and type 2 diabetes and healthy overweight controls, but has not yet been determined in patients with type 1 diabetes [16][17][18][19]. Furthermore, no postprandial data are available for anti-inflammatory mediators, i.e.…”

Section: Discussionmentioning

confidence: 98%

“…Thus, we analysed the association between systemic anti-inflammatory, proinflammatory and regulatory cytokines, and fasting and mixed-meal-stimulated beta cell function in patients with type 1 diabetes within the first year of diagnosis and also in those with longer term diabetes with confirmed residual beta cell function. Furthermore, we investigated the influence of a high-protein liquid mixed meal test (MMT) on the systemic immune status of patients with type 1 diabetes, since the secretion of cytokines can be affected by food intake [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes

et al. 2013

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Aims/hypothesis Cytokines may promote or inhibit disease progression in type 1 diabetes. We investigated whether systemic proinflammatory, anti-inflammatory and regulatory cytokines associated differently with fasting and mealstimulated beta cell function in patients with longer term type 1 diabetes. Methods The beta cell function of 118 patients with type 1 diabetes of duration of 0.75-4.97 years was tested using a standardised liquid mixed meal test (MMT). Serum samples A complete list of investigators is available in the electronic supplementary material (ESM).Electronic supplementary material The online version of this article

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“…Unexpectedly, there was a weak but significant positive correlation between plasma adiponectin concentrations and percentage of fat in the diet in non-carriers of the C allele, but not in carriers. Although the mechanism of this result is not clear, it was reported earlier that no correlation was found between dietary fat intake and plasma adiponectin concentration in humans, 14 suggesting that this relation may be specific for this genotype. Follow-up studies are necessary to clarify these points.…”

Section: Discussionmentioning

confidence: 56%

C allele of angiotensin II type 1 receptor gene A1166C polymorphism affects plasma adiponectin concentrations in healthy young Japanese women

et al. 2009

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Angiotensin II and its type 1 receptor (AT1R) are both expressed in the adipose tissue and involved in the genesis of atherosclerosis as well as hypertension. However, the influence of the AT1R gene A1166C polymorphism on atherosclerosis risk factors and on the development of early atherosclerosis is not clear. We evaluated 416 healthy young women to investigate the effects of this genotype on atherosclerosis risk factors and on carotid intima-media thickness as a validated marker of early atherosclerosis. After adjusting for confounding factors including body mass index, homeostasis model assessment of insulin resistance and plasma high-density lipoprotein (HDL)-cholesterol levels, plasma adiponectin concentrations were significantly lower in carriers of the C allele compared with non-carriers. Moreover, multiple logistic regression analysis showed that the C allele was the strongest and most independent determinant of lower plasma adiponectin concentrations. It is noted that the participants with the lowest quartile of plasma adiponectin concentrations had thicker levels of carotid intima-media thickness, lower plasma HDL-cholesterol and lipoprotein lipase levels, as well as higher trunk fat mass compared with the highest quartile. In addition, a weak but significant positive correlation was observed between percentages of fat in the diet and plasma adiponectin concentrations in non-carriers of the C allele. In conclusion, AT1R A1166C was associated with plasma adiponectin concentrations and influenced the correlations between dietary fat intake and plasma concentrations of adiponectin. These findings may help to identify vulnerable populations that are susceptible to the development of atherosclerosis and require early dietary recommendations for young women.

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Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

Cited by 97 publications

References 48 publications

Acute Effects of Dietary Fat on Inflammatory Markers and Gene Expression in First-Degree Relatives of Type 2 Diabetes Patients

Acute Effects of Dietary Fat on Inflammatory Markers and Gene Expression in First-Degree Relatives of Type 2 Diabetes Patients

Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes

C allele of angiotensin II type 1 receptor gene A1166C polymorphism affects plasma adiponectin concentrations in healthy young Japanese women

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