Preferential Uptake of Dietary Fatty Acids in Adipose Tissue and Muscle in the Postprandial Period

Bickerton, Alex; Roberts, Rachel; Fielding, Barbara A.; Hodson, Leanne; Blaak, Ellen E.; Wagenmakers, Anton J. M.; Gilbert, M.; Karpe, Fredrik; Frayn, Keith N.

doi:10.2337/db06-0822

Cited by 213 publications

(235 citation statements)

References 31 publications

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“…Bickerton [8] shows adipose tissue uptake 3 times more than skeletal muscle, therefore adipose uptake given by 72% of 0.1386. Negligible compared to insulin independent take up.…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

“…Adipose release of TAG to NEFA Approximated from data in Bickerton [8,9]. Obtained from a simple least squares data fit of experiments in [22] ( Figure 1A).…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

“…Approximated from data in Bickerton [8,9]. kga 1.67 × 10 6 mmol −1 Adipose uptake of glucose Rate chosen such that the adipose glucose steady state concentration is 2.54mmol/l [56].…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

“…Hodson et al [23] estimate 4% of TAG is taken up from the remnant particles by the liver. Bickerton [8] estimates adipose tissue takes up 3 times more TAG than skeletal muscle. Thus adipose tissue takes up 72% of 0.0262, whilst skeletal muscle takes up 24% of 0.0262.…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

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Mathematical modelling of hepatic lipid metabolism

Pratt

Wattis

Salter

2015

Mathematical Biosciences

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The aim of this paper is to develop a mathematical model capable of simulating the metabolic response to a variety of mixed meals in fed and fasted conditions with particular emphasis placed on the hepatic triglyceride element of the model. Model validation is carried out using experimental data for the ingestion of three mixed composition meals over a 24-hour period. Comparison with experimental data suggests the model predicts key plasma lipids accurately given a prescribed insulin profile. One counter-intuitive observation to arise from simulations is that liver triglyceride initially decreases when a high fat meal is ingested, a phenomenon potentially explained by the carbohydrate portion of the meal raising plasma insulin.

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“…Bickerton [8] shows adipose tissue uptake 3 times more than skeletal muscle, therefore adipose uptake given by 72% of 0.1386. Negligible compared to insulin independent take up.…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

“…Adipose release of TAG to NEFA Approximated from data in Bickerton [8,9]. Obtained from a simple least squares data fit of experiments in [22] ( Figure 1A).…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

“…Approximated from data in Bickerton [8,9]. kga 1.67 × 10 6 mmol −1 Adipose uptake of glucose Rate chosen such that the adipose glucose steady state concentration is 2.54mmol/l [56].…”

Section: Description Variable Steady Value Referencementioning

confidence: 99%

Section: Description Variable Steady Value Referencementioning

confidence: 99%

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Mathematical modelling of hepatic lipid metabolism

Pratt

Wattis

Salter

2015

Mathematical Biosciences

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“…We studied circulating NEFA concentrations in relation to other metabolic parameters in a large cohort of overweight, but healthy men stratified by fasting insulin concentration. We also conducted a detailed study of systemic, adipose tissue and skeletal muscle fatty acid metabolism in subgroups selected from this cohort, using stable-isotope tracer methodology combined with arterio-venous measurements as described recently [19].…”

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confidence: 99%

Adipose tissue fatty acid metabolism in insulin-resistant men

et al. 2008

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Aims/hypothesis Increased NEFA production and concentrations may underlie insulin resistance. We examined systemic and adipose tissue NEFA metabolism in insulinresistant overweight men (BMI 25-35 kg/m 2 ). Methods In a cohort study we examined NEFA concentrations in men in the upper quartile of fasting insulin (n=124) and in men with fasting insulin below the median (n = 159). In a metabolic study we examined NEFA metabolism in the fasting and postprandial states, in ten insulin-resistant men and ten controls. Results In the cohort study, fasting NEFA concentrations were not significantly different between the two groups (median values: insulin-resistant men, 410 µmol/l; controls, 445 µmol/l). However, triacylglycerol concentrations differed markedly (1.84 vs 1.18 mmol/l respectively, p<0.001). In the metabolic study, arterial NEFA concentrations again did not differ between groups, whereas triacylglycerol concentrations were significantly higher in insulin-resistant men. Systemic NEFA production and the release of NEFA from subcutaneous adipose tissue, expressed per unit of fat mass, were both reduced in insulin-resistant men compared with controls (fasting values by 32%, p=0.02, and 44%, p=0.04 respectively). 3-Hydroxybutyrate concentrations, an index of hepatic fat oxidation and ketogenesis, were lower (p=0.03). Conclusions/interpretation Adipose tissue NEFA output is not increased (per unit weight of tissue) in insulin resistance. On the contrary, it appears to be suppressed by high fasting insulin concentrations. Alterations in triacylglycerol metabolism are more marked than those in NEFA metabolism and are indicative of altered metabolic partitioning of fatty acids (decreased oxidation, increased esterification) in the liver.

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Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans

Goossens

Blaak

2011

Applications of Microdialysis in Pharmaceutical Science

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Preferential Uptake of Dietary Fatty Acids in Adipose Tissue and Muscle in the Postprandial Period

Cited by 213 publications

References 31 publications

Mathematical modelling of hepatic lipid metabolism

Mathematical modelling of hepatic lipid metabolism

Adipose tissue fatty acid metabolism in insulin-resistant men

Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans

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