Prevalence and correlation of anxiety and depression on the prognosis of postoperative non-small-cell lung cancer patients in North China

Abstract

Identify the prevalence of postoperative anxiety and depression as well as their correlations with clinical features and survival profiles in non-small-cell lung cancer (NSCLC) patients who underwent resection. Four hundred NSCLC patients who underwent resection were recruited, and their anxiety and depression were assessed by hospital anxiety and depression scale (HADS) at discharge after surgery. Besides, 480 healthy controls (HCs) were also enrolled and assessed by HADS. The HADS-Anxiety score of NSCLC patients (7.8 ± 3.9) was greatly higher than that of HCs (4.8 ± 2.7), and the anxiety prevalence of NSCLC patients (49.6%) were dramatically increased compared with HCs (13.8%). Furthermore, the HADS-Depression score (7.2 ± 3.6) of NSCLC patients was considerably increased compared with HCs (4.2 ± 2.6), and the depression prevalence of NSCLC patients (38.3%) was significantly raised compared with HCs (10.0%). Besides, anxiety correlated with gender, marital status, hypertension, diabetes, pathological differentiation, tumor size, lymph node metastasis, TNM stage and carcinoembryonic antigen level, meanwhile, depression correlated with marital status, employment status before surgery, diabetes, pathological differentiation, and TNM stage in NSCLC patients. Additionally, the anxiety and depression predicted shorter disease-free survival in NSCLC patients. And the anxiety predicted worse overall survival (OS), while no association of depression with OS was observed in NSCLC patients. Post-operative anxiety and depression are highly prevalent and implicated in the ongoing care and prognosis prediction in NSCLC patients who underwent resection.

Post-surgery anxiety and depression in prostate cancer patients: prevalence, longitudinal progression, and their correlations with survival profiles during a 3-year follow-up

“…For example, a previous study reveals that in oropharynx cancer patients, the self-report depression independently correlates with unfavorable OS and DFS, which is partially similar to our results [28]. In accordance with this, another study reports that in postoperative non-small cell lung cancer patients, post-surgery anxiety predicts shorter OS, and post-surgery anxiety and depression both predict less prolonged DFS [29]. In terms of our results, we tried to explain them by the following possible reasons.…”

Reminiscence therapy‐based care program relieves anxiety, depression, and improves quality of life in post‐operational non‐small cell lung cancer patients

“…Anxiety and depression, as serious recurrent psychological disorders, prevalently occur in the post‐operational patients with non‐small cell lung cancer (NSCLC), which reduce patients’ capability to tolerate aggressive therapy and treatment‐related complications 1,2 . Meanwhile, health‐related quality of life (QoL) reflects physical and psychosocial conditions of patients, which recently has been considered as an important clinical aspect for post‐operational NSCLC management 3 . According to existing evidence, it is common that anxiety and depression coexist with impaired health‐related QoL, which together decrease treatment adherence and encumber recovery after resection, further elevating mortality in post‐operational NSCLC patients 4 .…”

“…| 473 LIU and LI management. 3 According to existing evidence, it is common that anxiety and depression coexist with impaired healthrelated QoL, which together decrease treatment adherence and encumber recovery after resection, further elevating mortality in post-operational NSCLC patients. 4 Therefore, various rehabilitation programs attempting to relieve the symptoms of anxiety and depression, and further promote health-related QoL, are required for the post-operational management in NSCLC patients.…”

Hospital anxiety and depression scale exhibits good consistency but shorter assessment time than Zung self-rating anxiety/depression scale for evaluating anxiety/depression in non-small cell lung cancer

“…[ 6 , 7 ] Based on the current information, there are generally 20% to 40% of cancer patients present anxiety and depression, most of which are assessed by these 2 scales, and both anxiety and depression are correlated with advanced disease state, severe symptoms as well as poor prognosis. [ 8 ] As for in NSCLC, the assessments of anxiety and depression using SAS/SDS or HADS also exist, however, there is absence of evidence about which scale is more suitable. [ 8 , 9 ] Hence, we thought that instruction about the superiority between SAS/SDS and HADS in assessing anxiety/depression in NSCLC patients would help clinicians’ choice for appropriate measurements.…”

“…[ 8 ] As for in NSCLC, the assessments of anxiety and depression using SAS/SDS or HADS also exist, however, there is absence of evidence about which scale is more suitable. [ 8 , 9 ] Hence, we thought that instruction about the superiority between SAS/SDS and HADS in assessing anxiety/depression in NSCLC patients would help clinicians’ choice for appropriate measurements.…”