Production of succinic acid by bacterial fermentation

Song, Hyohak; Lee, Sang Yup

doi:10.1016/j.enzmictec.2005.11.043

Cited by 697 publications

(373 citation statements)

References 56 publications

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“…Currently used in the agricultural, food, and pharmaceutical industries, succinic acid can easily be converted into a wide variety of products including biodegradable plastics and green solvents [46,47]. Although there have been numerous studies on the conversion of sugars to succinic acid [47], only a small number of reports document the anaerobic conversion of glycerol to succinic acid.…”

Section: Succinic Acidmentioning

confidence: 99%

Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals

Clomburg

González

2013

Trends in Biotechnology

260

178

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Section: Succinic Acidmentioning

confidence: 99%

Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals

Clomburg

González

2013

Trends in Biotechnology

260

178

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“…There have been several extensive reviews that detail the succinic acid market, and more specifically, comprehensively present the various metabolic engineering strategies coupled with application of systems biology that have been employed to date (Jantama et al, 2008;McKinlay et al, 2007;Song and Lee, 2006;Zeikus et al, 1999). The two organisms that have been most significantly engineered from native isolations are E. coli and M. succiniciproducens, and for illustrative purposes, only M. succiniciproducens will be highlighted as it epitomizes the potential for industrial systems biology.…”

Section: In Development: Succinic Acidmentioning

confidence: 99%

Industrial systems biology

Otero

Nielsen

2009

Biotech & Bioengineering

132

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ABSTRACT:The chemical industry is currently undergoing a dramatic change driven by demand for developing more sustainable processes for the production of fuels, chemicals, and materials. In biotechnological processes different microorganisms can be exploited, and the large diversity of metabolic reactions represents a rich repository for the design of chemical conversion processes that lead to efficient production of desirable products. However, often microorganisms that produce a desirable product, either naturally or because they have been engineered through insertion of heterologous pathways, have low yields and productivities, and in order to establish an economically viable process it is necessary to improve the performance of the microorganism. Here metabolic engineering is the enabling technology. Through metabolic engineering the metabolic landscape of the microorganism is engineered such that there is an efficient conversion of the raw material, typically glucose, to the product of interest. This process may involve both insertion of new enzymes activities, deletion of existing enzyme activities, but often also deregulation of existing regulatory structures operating in the cell. In order to rapidly identify the optimal metabolic engineering strategy the industry is to an increasing extent looking into the use of tools from systems biology. This involves both x-ome technologies such as transcriptome, proteome, metabolome, and fluxome analysis, and advanced mathematical modeling tools such as genome-scale metabolic modeling. Here we look into the history of these different techniques and review how they find application in industrial biotechnology, which will lead to what we here define as industrial systems biology.

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“…Recently, many reviews have shown that fermentative production of succinic acid can be more cost-effective than petroleumbased production schemes. [1][2][3] This type of "green" technology is becoming more popular as a means of decreasing pollution caused by many petrochemical processes. Dialkyl esters of succinic acid are widely used in detergents, cosmetics, pharmaceuticals, and processed foods.…”

Section: Introductionmentioning

confidence: 99%

“…Dialkyl esters of succinic acid are widely used in detergents, cosmetics, pharmaceuticals, and processed foods. [1][2][3] For example, dialkyl ester derivatives of diacids including succinic acid make excellent lubricants and can enhance the quality of diesel fuel when used as additives. [4][5][6] Similar approaches using fatty acid derivatives, commonly known as biodiesel, have recently been reported.…”

Section: Introductionmentioning

confidence: 99%

Detection of Long Alkyl Esters of Succinic and Maleic Acid Using TLC-MALDI-MS

Kim¹,

Han²,

Kim³

et al. 2011

Bulletin of the Korean Chemical Society

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Four esters of succinic and maleic acid were synthesized, separated by thin-layer chromatography (TLC), and identified using matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). A comparison of matrix materials showed that 2,6-dihydroxybenzoic acid (2,6-DHB) yielded a greater ionization efficiency than 2,5-DHB prior to TLC separation. The location of each ester sample on the TLC plate was estimated by comparing the developed plate with a duplicate plate that had been visualized by immersion in a KMnO4 solution. Generally, mass spectra obtained from the KMnO4-visualized plate were relatively poor. Reproducible mass spectra with high peak abundance were difficult to obtain using the 2,6-DHB matrix from crude synthetic esters extracted from the TLC plates. Significant improvements in both reproducibility and sensitivity were realized by using pencil lead as the MALDI matrix. The current methodology will be beneficial to organic chemists since it can provide a guideline for simple and rapid characterization of small organic compounds.

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Production of succinic acid by bacterial fermentation

Cited by 697 publications

References 56 publications

Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals

Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals

Industrial systems biology

Detection of Long Alkyl Esters of Succinic and Maleic Acid Using TLC-MALDI-MS

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