Psychophysiological effects of an iTBS modulated virtual reality challenge including participants with spider phobia

Notzon, Swantje; Deppermann, Saskia; Fallgatter, Andreas J.; Diemer, Julia; Kroczek, Agnes; Domschke, Katharina; Zwanzger, Peter; Ehlis, Ann‐Christine

doi:10.1016/j.biopsycho.2015.10.003

Cited by 50 publications

(96 citation statements)

References 52 publications

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“…Two studies used single‐session paradigms with a translational (not therapeutic) aim that are informative in the context of this review. These studies evaluated rTMS or excitatory intermittent theta burst stimulation (iTBS) as a treatment for SP (Herrmann & Ebmeier, ; Notzon et al, ). Notzon et al () evaluated the effects of one iTBS session on virtual reality‐provoked anxiety in 41 patients with spider phobia and 42 healthy controls randomized to active or sham iTBS; however, they measured the fear of spiders (SPQ), anxiety (ASI), and disgust sensitivity (DS) using questionnaires.…”

Section: Resultsmentioning

confidence: 99%

“…These studies evaluated rTMS or excitatory intermittent theta burst stimulation (iTBS) as a treatment for SP (Herrmann & Ebmeier, ; Notzon et al, ). Notzon et al () evaluated the effects of one iTBS session on virtual reality‐provoked anxiety in 41 patients with spider phobia and 42 healthy controls randomized to active or sham iTBS; however, they measured the fear of spiders (SPQ), anxiety (ASI), and disgust sensitivity (DS) using questionnaires. They stimulated the lDLPFC using 600 pulses and the traditional iTBS protocol (50 Hz triplets every 200 ms for 2 s on and an intertrain interval of 8 s) with a pulse intensity of 80% of the resting motor threshold (RMT).…”

Section: Resultsmentioning

confidence: 99%

“…These studies evaluated rTMS or excitatory intermittent theta burst stimulation (iTBS) as a treatment for SP (Herrmann & Ebmeier, 2006;Notzon et al, 2015). Notzon et al (2015) interval of 8 s) with a pulse intensity of 80% of the resting motor threshold (RMT). One session of iTBS showed no improvement.…”

Section: Tms and Specific Phobiamentioning

confidence: 99%

“…Ten of the 17 studies (59%) included in this meta-analysis presented adverse events (Boggio et al, 2011;Cohen et al, 2004;Diefenbach et al, 2016;Dilkov et al, 2017;Herrmann & Ebmeier, 2006;Isserles et al, 2013;Mantovani et al, 2013;Nam et al, 2013;Notzon et al, 2015;Rosenberg et al, 2002). Most of the side effects were mild to moderate.…”

Section: Side Effects Of Tmsmentioning

confidence: 99%

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Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

et al. 2019

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Background Transcranial magnetic stimulation (TMS) has been evaluated as an effective treatment option for patients with major depressive disorder. However, there are limited studies that have evaluated the efficacy of TMS for other neuropsychiatric disorders such as anxiety and trauma‐related disorders. We reviewed the literature that has evaluated TMS as a treatment for anxiety and trauma‐related disorders. Methods We searched for articles published up to December 2017 in Embase, Medline, and ISI Web of Science databases, following the Preferred Items for Reporting of Systematic Reviews and Meta‐Analyses (PRISMA) statement. Articles ( n = 520) evaluating TMS in anxiety and trauma‐related disorders were screened and a small subset of these that met the eligibility criteria ( n = 17) were included in the systematic review, of which nine evaluated TMS in posttraumatic stress disorder (PTSD), four in generalized anxiety disorder (GAD), two in specific phobia (SP), and two in panic disorder (PD). The meta‐analysis was performed with PTSD and GAD since PD and SP had an insufficient number of studies and sample sizes. Results Among anxiety and trauma‐related disorders, TMS has been most widely studied as a treatment for PTSD. TMS demonstrated large overall treatment effect for both PTSD (ES = −0.88, 95% CI: −1.42, −0.34) and GAD (ES = −2.06, 95% CI: −2.64, −1.48), including applying high frequency over the right dorsolateral prefrontal cortex. Since few studies have evaluated TMS for SP and PD, few conclusions can be drawn. Conclusions Our meta‐analysis suggests that TMS may be an effective treatment for GAD and PTSD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Tms and Specific Phobiamentioning

confidence: 99%

Section: Side Effects Of Tmsmentioning

confidence: 99%

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Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

et al. 2019

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“…To mention but a few examples beyond the gaming scene, VR is now widely used in medical applications for physical rehabilitation (Paolini et al, 2013;Baldominos, Saez & Del Pozo, 2015;Draganov & Boumbarov, 2015;Morel et al, 2015;Donati et al, 2016;Shokur et al, 2016), exposure therapy for phobias and post-traumatic stress (Notzon et al, 2015;Cuperus et al, 2016), treatment for addiction (Park et al, 2016) and even autism (Didehbani et al, 2016). Other fields such as architecture and urban planning (Portman, Natapov & Fisher-Gewirtzman, 2015;Luigi et al, 2015) and education (Abulrub, Attridge & Williams, 2011) also benefit from the technology.…”

Section: Introductionmentioning

confidence: 99%

A method for creating interactive, user-resembling avatars

Silva

Moioli²

2017

PeerJ Computer Science

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Virtual reality (VR) applications have disseminated throughout several fields, with a special quest for immersion. The avatar is one of the key constituents of immersive applications, and avatar resemblance can provoke diverse emotional responses from the user. Yet a lot a virtual reality systems struggle to implement real life-like avatars. In this work, we propose a novel method for creating interactive, user-resembling avatars using available commercial hardware and software. Avatar visualization is possible with a point-cloud or a contiguous polygon surface, and avatar interactions with the virtual scenario happens through a body joint-approximation for contact. In addition, the implementation could be easily extended to other systems and its modular architecture admits improvement both on visualization and physical interactions. The code is under Apache License 2.0 and is freely available as Supplemental Information 1 in this article.

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The effects of noninvasive brain stimulation on heart rate and heart rate variability: A systematic review and meta‐analysis

Schmaußer

Hoffmann

Raab

et al. 2022

J of Neuroscience Research

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Psychophysiological effects of an iTBS modulated virtual reality challenge including participants with spider phobia

Cited by 50 publications

References 52 publications

Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

Transcranial magnetic stimulation in anxiety and trauma‐related disorders: A systematic review and meta‐analysis

A method for creating interactive, user-resembling avatars

The effects of noninvasive brain stimulation on heart rate and heart rate variability: A systematic review and meta‐analysis

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