Putting a spin on the dorsal–ventral divide of the striatum

Voorn, Pieter; Vanderschuren, Louk J. M. J.; Groenewegen, Henk J.; Robbins, Trevor W.; Pennartz, Cyriel M. A.

doi:10.1016/j.tins.2004.06.006

Cited by 1,023 publications

(1,014 citation statements)

References 67 publications

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“…Also potentially relevant here is the finding that reversible inactivation of the dorsomedial prefrontal cortex (tetrodotoxin injections), but not the ventromedial prefrontal cortex, attenuates context-induced reinstatement of cocaine seeking, as measured in a procedure similar to the one used in our study (Fuchs et al, 2005). Glutamatergic projections from the dorsomedial and ventromedial prefrontal cortex preferentially innervate the NAc core and shell, respectively (Voorn et al, 2004).…”

Section: Role Of the Nac Core And Shell In Drug Seekingmentioning

confidence: 72%

Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Bossert

Gray

Lü

et al. 2005

Neuropsychopharmacol

213

172

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Using a rat relapse model, we previously reported that re-exposing rats to a drug-associated context, following extinction of operant responding in a different context, reinstates heroin seeking. In an initial pharmacological characterization, we found that the mGluR 2/3 agonist LY379268, which acts centrally to reduce evoked glutamate release, attenuates context-induced reinstatement of heroin seeking when injected systemically or into the ventral tegmental area, the cell body region of the mesolimbic dopamine system. Here, we tested whether injections of LY379268 into the nucleus accumbens (NAc), a terminal region of the mesolimbic dopamine system, would also attenuate context-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin; drug infusions were paired with a discrete tone-light cue. Subsequently, lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. After extinction of responding, LY379268 was injected to different groups of rats into the NAc core or shell or into the caudate-putamen, a terminal region of the nigrastriatal dopamine system. Injections of LY379268 into the NAc shell (0.3 or 1.0 mg) dose-dependently attenuated context-induced reinstatement of heroin seeking. Injections of 1.0 mg of LY379268 into the NAc core had no effect, while a higher dose (3.0 mg) decreased this reinstatement. Injections of LY379268 (3.0 mg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking.

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Section: Role Of the Nac Core And Shell In Drug Seekingmentioning

confidence: 72%

Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Bossert

Gray

Lü

et al. 2005

Neuropsychopharmacol

213

172

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“…Given the different prescribed roles of the dorsal and ventral striatum (Gerdeman et al, 2003;White, 1996), it is presumed that the location of the ACh interneurons may have a significant effect on interpretationFalthough no such relationship was apparent in the reviewed studies. It is also noteworthy that the dorsal/ventral striatal distinction has recently come under question (suggesting a ventromedial vs dorsolateral distinction) (Voorn et al, 2004), further complicating any attempt to ascribe regional effects of striatal ACh. As noted previously, the excitatory and inhibitory effects of striatal ACh further complicate any generalized assumption of cholinergic effect and cocaine administration.…”

Section: Striatal Acetylcholine and Rewardmentioning

confidence: 99%

The Role of Acetylcholine in Cocaine Addiction

Williams

Adinoff²

2007

Neuropsychopharmacol

157

138

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Central nervous system cholinergic neurons arise from several discrete sources, project to multiple brain regions, and exert specific effects on reward, learning, and memory. These processes are critical for the development and persistence of addictive disorders. Although other neurotransmitters, including dopamine, glutamate, and serotonin, have been the primary focus of drug research to date, a growing preclinical literature reveals a critical role of acetylcholine (ACh) in the experience and progression of drug use. This review will present and integrate the findings regarding the role of ACh in drug dependence, with a primary focus on cocaine and the muscarinic ACh system. Mesostriatal ACh appears to mediate reinforcement through its effect on reward, satiation, and aversion, and chronic cocaine administration produces neuroadaptive changes in the striatum. ACh is further involved in the acquisition of conditional associations that underlie cocaine self-administration and context-dependent sensitization, the acquisition of associations in conditioned learning, and drug procurement through its effects on arousal and attention. Long-term cocaine use may induce neuronal alterations in the brain that affect the ACh system and impair executive function, possibly contributing to the disruptions in decision making that characterize this population. These primarily preclinical studies suggest that ACh exerts a myriad of effects on the addictive process and that persistent changes to the ACh system following chronic drug use may exacerbate the risk of relapse during recovery. Ultimately, ACh modulation may be a potential target for pharmacological treatment interventions in cocaine-addicted subjects. However, the complicated neurocircuitry of the cholinergic system, the multiple ACh receptor subtypes, the confluence of excitatory and inhibitory ACh inputs, and the unique properties of the striatal cholinergic interneurons suggest that a precise target of cholinergic manipulation will be required to impact substance use in the clinical population.

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“…This study suggested that flow proneness is associated with dopaminergic transmission in the dorsal striatum, which is associated with reward processing, impulse control, and positive affect [5,6]. Klasen et al [7] used functional magnetic resonance imaging (fMRI) to evaluate brain activity during flow and demonstrated increased activity in midbrain reward structures as well as a complex network of sensorimotor, cognitive and 6 emotional brain circuits during a state of flow.…”

Section: Introductionmentioning

confidence: 98%