Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

Abstract

This study analyzes the proteomes and phospho-proteomes of isogenic DLD-1 cancer cells differing in karyotypes and chromosome stability. Chromosome doubling is shown to trigger more extensive changes in (phospho-)proteomes than chromosome instability, and activation of mitotic pathways may explain differential responses to mitotic inhibitors.