Randomized controlled trials in pediatric complementary and alternative medicine: Where can they be found?

Sampson, Margaret; Campbell, Kaitryn; Ajiferuke, Isola; Moher, David

doi:10.1186/1471-2431-3-1

Cited by 35 publications

(28 citation statements)

References 23 publications

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“…1 There is little evidence available to guide the use of CAM products in pediatrics, 36 and existing studies have been criticized for low quality and lack of specific information on safety. 37,38 Lay sources of information available to parents, such as health food store attendants or the Internet, have been found to provide information on CAM products that has been characterized as misleading at best and dangerous at worst. 39,40 Furthermore, there are no mandatory quality standards for many CAM products, 14 and a number of such products can be harmful when taken by children.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Pediatric and Adolescent Patients Attending a Naturopathic College Clinic in Canada

Wilson¹,

Busse

Gilchrist

et al. 2005

Pediatrics

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ABSTRACT. Objectives. The use of complementary and alternative medicine (CAM) has grown substantially in North America and has drawn the attention of conventional-medicine practitioners. Conventional-medicine practitioners have expressed concern about the potential for unregulated CAM therapies to cause harm, the sometimes-uncertain cost-benefit ratios associated with these therapies, and the possibility that some CAM providers might advise against established conventional therapies, such as vaccination. These concerns are heightened with respect to the pediatric use of CAM products. To address this issue, we conducted a systematic audit of pediatric and adolescent case files at a large, college-based, Canadian naturopathic teaching clinic. We specifically sought to describe the demographic characteristics, reasons for presentation, use of CAM products, and vaccinations status of children presenting for naturopathic assessment. We also determined factors associated with the use of CAM products and vaccination status.Methods. We identified all charts for children (<18 years of age) who presented to the Robert Schad Naturopathic Clinic, the teaching clinic of the Canadian College of Naturopathic Medicine, between February 1 and May 31, 2002. Data were abstracted directly from the standardized patient intake forms and from clinical notes recorded during the patient's initial visit to the clinic. The following data were obtained: age, gender, chief presenting complaints reported by parents, CAM product use at presentation, vaccination status, and reactions to vaccination. We conducted logistic regression analyses to identify factors associated with both CAM product use and vaccination status.Results. A total of 482 charts were identified. The mean age of patients was 6.5 years (95% confidence interval [CI]: 1.6 -11.4 years). The ratio of female subjects to male subjects was 1.09:1 (248:227). The most common reasons for presentation were skin disorders (23%), gastrointestinal complaints (17%), and psychiatric/behavioral disorders (15%). Thirty-five percent of children were using CAM products at presentation (21.2% when both vitamins and minerals were excluded). Vitamins were the most commonly used products (34.6%), followed by herbal remedies (14.9%), oil blends/fats (7.2%), minerals (5.6%), probiotics (4.5%), and homeopathic remedies (3.7%). Of charts with vaccination information, 8.9% indicated that children had not been vaccinated; possible vaccine-associated adverse events were reported for 27% of those who had been vaccinated.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Pediatric and Adolescent Patients Attending a Naturopathic College Clinic in Canada

Wilson¹,

Busse

Gilchrist

et al. 2005

Pediatrics

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“…24 Reports of 908 RCTs were identified by searching MEDLINE and 12 additional bibliographic databases, and by reviewing the reference lists of previously identified paediatric CAM systematic reviews. It was found that a search of MEDLINE alone could potentially identify 97.7% of these reports, and a search combining MEDLINE, EMBASE and CAB Health could achieve 99.4% retrieval.…”

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confidence: 99%

Literature searching for clinical and cost-effectiveness studies used in health technology assessment reports carried out for the National Institute for Clinical Excellence appraisal system

Royle

Waugh²

2003

Health Technol Assess

176

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email.Paying by official purchase order You can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. The editors and publisher have tried to ensure the accuracy of this report but do not accept liability for damages or losses arising from material published in this report. HTAISSN 1366-5278 © Queen's Printer and Controller of HMSO 2003This monograph may be freely reproduced for the purposes of private research and study and may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising.Applications for commercial reproduction should be addressed to HMSO,The Copyright Unit, St Clements House, 2-16 Colegate, Norwich, NR3 1BQ.Published by Gray Publishing, Tunbridge Wells, Kent, on behalf of NCCHTA.Printed on acid-free paper in the UK by St Edmundsbury Press Ltd, Bury St Edmunds, Suffolk. Criteria for inclusion in the HTA monograph seriesReports are published in the HTA monograph series if (1) they have resulted from work commissioned for the HTA Programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search, appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. O2Objective: To contribute to making searching for Technology Assessment Reports (TARs) more costeffective by suggesting an optimum literature retrieval strategy. Data sources: A sample of 20 recent TARs. Review methods: All sources used to search for clin...

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“…Journals that use the CONSORT guideline have higher quality of RCTs, compared with journals that do not (4).…”

Section: Discussionmentioning

confidence: 99%

Quality Assessment of Published Randomized, Controlled Trials in Trauma Monthly Journal

Salesi¹,

Rasouli²,

Mohammadi³

et al. 2017

Trauma Mon

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Context: Randomized controlled trials (RCTs) have a major role in making the evidence-based decisions on healthcare. Therefore, the assessment of the quality of RCTs is important to properly apply the evidence-based healthcare. The current study aimed at assessing the quality of RCT reports published in Trauma Monthly Journal. Evidence Acquisition: The quality assessment of each report was performed using a checklist based on the CONSORT (consolidated standards of reporting trials) Statement and Jadad criteria. Results: Fifteen RCTs were published from 2011 to 2015 in Trauma Monthly journal out of which 5 (33.3%) reported the pain outcomes, 7 (46.6%) reports included surgical interventions, and 3 (33.3%) reports included patients with different types of fractures. According to the CONSORT checklist, the best report belonged to the definition of interventions for each group with sufficient details. The mean score of Jadad was 2.27 (45.4% of maximum possible total score). According to both scales, there was an increase in the periods of time in the quality of reporting. Conclusions:The results showed a moderate quality score in RCTs and a minor improvement over the years. Training courses for researchers, managing reporting standard tools presented by editors (CONSORT checklist) and employing methodologists and statistical experts can develop the quality of published RCTs.Keywords: Quality Assessment, Randomized Controlled Trial, Checklist, Trauma Context Quality Assessment of Randomized Controlled TrialsRCTs are often performed to assess the effect of new treatments and are considered evidence-based for clinical trials (1). Therefore, it is of paramount importance to design and report high-quality RCTs. Also, for proper use and exploration of the evidence-based approach, it is important and necessary to assess the quality of RCTs.The quality of a trial was explained by the validity and accuracy of analysis and design. But, the quality of reporting was explained as reporting characteristics about the analysis and design of the RCT (2).There are various approaches to assess the quality of RCTs. It is usually performed using 3 tools of the component, checklist, and scale.Also, the quality of RCTs was evaluated in the metaanalysis studies. The CONSORT (consolidated standards of reporting trials) guidelines and Jadad criteria are often used in meta-analysis studies. Recently, to integrate the results of RCTs, meta-analyses are conducted increasingly (3, 4). Therefore, there is a great interest to evaluate the quality of RCTs to include them in the meta-analyses (5-7). Therefore, since the quality of trials affect the results of meta-analyses, results may be less valuable if the quality of RCTs is not assessed (2). To achieve the valuable results of a trial, the quality of RCT is very important.It is recommended that journals implement more CONSORT guidelines (8). The works should be complete and clear before publishing.However, RCTs are increasingly published in journals (9). It is important for the promotion ...

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Randomized controlled trials in pediatric complementary and alternative medicine: Where can they be found?

Cited by 35 publications

References 23 publications

Characteristics of Pediatric and Adolescent Patients Attending a Naturopathic College Clinic in Canada

Characteristics of Pediatric and Adolescent Patients Attending a Naturopathic College Clinic in Canada

Literature searching for clinical and cost-effectiveness studies used in health technology assessment reports carried out for the National Institute for Clinical Excellence appraisal system

Quality Assessment of Published Randomized, Controlled Trials in Trauma Monthly Journal

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