Relationship between blood type and outcomes following COVID-19 infection

Kim, Young; Latz, Christopher A.; DeCarlo, Charles; Lee, Sujin; Png, C.Y. Maximilian; Kibrik, Pavel; Sung, Eric; Alabi, Olamide; Dua, Anahita

doi:10.1053/j.semvascsurg.2021.05.005

Cited by 39 publications

(30 citation statements)

References 53 publications

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“…Different cohort groups studied might explain discrepant results: While those studies documenting a lower infection risk for blood group 0 mainly focus on patients with severe disease course, studies indicating no difference focus on cases of rather mild disease course. However, there is growing evidence that blood group 0 has a lower risk for severe disease course [ 39 , 44 ]. Furthermore, AB individuals were demonstrated to have a higher risk for a SARS-CoV-2 infection [ 35 , 45 ], severe disease course including the necessity of ventilation [ 33 , 34 ] and increased mortality [ 33 ] compared to other AB0 blood groups.…”

Section: Discussionmentioning

confidence: 99%

Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection

Nunhofer

Weidner

Hoeggerl

et al. 2022

Viruses

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The developmental course of antibodies produced after a SARS-CoV-2 infection has been insufficiently investigated so far. Therefore, the aim of this study was to investigate the dynamics of SARS-CoV-2 antibody levels against the viral nucleocapsid- and spike-protein among Austrian blood donors as a representative group of a supposedly healthy population within the first year after a SARS-CoV-2 infection. The impact of age, sex, vaccination status, AB0-blood group and awareness about the infection was evaluated. Our study shows that the level of anti-N antibodies is declining, while anti-S antibody levels remain stable. Antibodies detected were functional in vitro. Age, sex and blood group do not influence antibody dynamics. However, blood group AB shows significantly lower antibody levels and in vitro functionality compared to other blood groups. Our data reveal that one out of five individuals was not aware of a previous SARS-CoV-2 infection and that the disease course neither affects the level of antibody production nor the in vitro functionality. We also found that 14% of participants show persisting COVID-19-related symptoms for up to nine months. Our results provide valuable insights into the dynamics of the immune response after a SARS-CoV-2 infection in a representative cohort of adult blood donors in Central Europe.

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Section: Discussionmentioning

confidence: 99%

Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection

Nunhofer

Weidner

Hoeggerl

et al. 2022

Viruses

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“…Similar findings were reported by Boudin et al, although they examined mainly male young population, while in our study both genders in several age groups were included [ 47 ]. Other studies discovered that RhD-negative individuals are at lower risk of SARS-CoV-2 infection, but found no correlation with the severity of COVID-19 [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

Grujic

Bujandric

Budakov-Obradović

et al. 2021

IJERPH

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Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals (n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals (p = 0.034), older age groups (p < 0.001), existence of hypertension (p = 0.008), and severe COVID-19 (p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity.

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“…Therefore, it is primarily of clinical interest in the context of haemolytic reactions (of the newborn and in the case of blood transfusion). Individuals who are RhD-negative may have some protection against COVID-19 infection, but the pathophysiological basis is unclear [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the emergence of the Coronavirus disease 2019 (COVID-19) pandemic, recent intense research efforts have been directed towards investigating the ABO blood group as putative risk factors for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease. Although results are equivocal, blood group O appears to be protective against COVID-19 infection compared to non-O blood groups, particularly blood group A [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

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ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patients

et al. 2022

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Background The ABO and RhD blood group represent antigens on the surface of erythrocytes. The ABO blood group antigens are also present on multiple other cells. Interestingly, previous studies have demonstrated associations between the blood group and many types of disease. The present study aimed to identifying associations between the ABO blood group, the RhD blood group, and morbidity and mortality in a mixed cohort and in six pre-defined subgroups of critically ill patients. Methods Adult patients admitted to any of the five intensive care units (ICUs) in the Scania Region, Sweden, between February 2007 and April 2021 were eligible for inclusion. The outcomes were mortality analysed at 28– and 90–days as well as at the end of observation and morbidity measured using days alive and free of (DAF) invasive ventilation (DAF ventilation) and DAF circulatory support, including vasopressors or inotropes (DAF circulation), maximum Sequential Organ Failure Assessment score (SOFAmax) the first 28 days after admission and length of stay. All outcomes were analysed in separate multivariable regression models adjusted for age and sex. In addition, in a sensitivity analysis, five subgroups of patients with the main diagnoses sepsis, septic shock, acute respiratory distress syndrome, cardiac arrest and trauma were analysed using the same separate multivariable regression models. Results In total, 29,512 unique patients were included in the analyses. There were no significant differences for any of the outcomes between non-O blood groups and blood group O, or between RhD blood groups. In the sensitivity analysis of subgroups, there were no differences in mortality between non-O blood groups and blood group O or between the RhD blood groups. AB was the most common blood group in the COVID-19 cohort. Conclusions The ABO and RhD blood group do not influence mortality or morbidity in a general critically ill patient population.

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Relationship between blood type and outcomes following COVID-19 infection

Cited by 39 publications

References 53 publications

Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection

Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patients

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