Relationships between Serum Resistin and Fat Intake, Serum Lipid Concentrations and Adiposity in the General Population

León, Antonio Cabrera de; González, Delia Almeida; Hernández, Ana González; Coello, Santiago Domínguez; Marrugat, Jaume; Sánchez, José Juan Alemán; Díaz, Buenaventura Brito; Rodríguez, Itahisa Marcelino; Pérez, María del Cristo Rodríguez

doi:10.5551/jat.22103

Cited by 35 publications

(27 citation statements)

References 40 publications

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“…Furthermore, patients with the highest plasma resistin, possess a more pro-atherogenic lipid status: HDL-C concentrations were the lowest in that group. In line with previously reported results ( 13 ), plasma resistin was negatively associated with TC and TC concentrations were the lowest in patients with the highest plasma resistin, which could be a consequence of the negative association observed with HDL-C concentrations. Sato and co-workers reported that mouse resistin protein can attenuate ApoA1 mRNA expression in the liver, which could be the cause of lower HDL-C concentrations seen in mice treated with resistin adenovirus ( 26 ).…”

Section: Discussionsupporting

confidence: 93%

“…Other studies have examined connections between plasma resistin and HDL-C concentrations ( 12 , 13 ). We have shown for the first time that not only plasma resistin but also its PBMC mRNA are inversely related to HDL-C.…”

Section: Discussionmentioning

confidence: 99%

“…Data from clinical studies have revealed an association between resistin protein and traditional risk factors for atherosclerosis: Inverse correlations were observed with protective high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC); positive correlations were observed with triglycerides (Tg), high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA-IR) ( 12 , 13 ). Plasma resistin has also been shown to be positively correlated with creatinine and was dependent on kidney function: Elevated resistin concentrations in chronic kidney disease were associated with decreased glomerular filtration rate (GFR) ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease

Joksić

Sopić

Spasojević‐Kalimanovska

et al. 2015

Biochem Med

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IntroductionPrevious studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity.Material and methodsThis study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR.ResultsResistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (ρ = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (ρ = -0.404, P < 0.001 and ρ = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (ρ = 0.353, P = 0.002).ConclusionSignificant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease

Joksić

Sopić

Spasojević‐Kalimanovska

et al. 2015

Biochem Med

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“…The methods to obtain these variables have been described [4, 22, 23, and 26]. All data is available as supporting information (S1 Database).…”

Section: Methodsmentioning

confidence: 99%

Inverse association of resistin with physical activity in the general population

et al. 2017

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AimResistin is a cytokine related with inflammation and ischemic heart disease. Physical activity (PA) prevents chronic inflammation and ischemic heart disease. We studied the relationship of serum concentration of resistin with HDL cholesterol, a known biomarker of PA, and with different measures of PA, in a large sample of the general adult population in the Canary Islands.MethodsCross-sectional study of 6636 adults recruited randomly. We analyzed the correlation of resistin and HDL cholesterol with PA (as metabolic equivalent level [MET]), and fitted the results with linear and logistic regression models using adjustment for age, alcohol consumption and smoking.ResultsMean resistin level was higher in women (p<0.001), correlated inversely with age, HDL cholesterol (p<0.001) and alcohol consumption (p<0.001 in men), and correlated directly with smoking (p<0.001). Resistin correlated inversely with the duration of leisure time PA (p<0.001), leisure time MET (p<0.001) and moderate leisure time PA (p<0.001), with some differences between sexes. Men (OR = 0.78 [0.61–0.99; p<0.05]) and women (OR = 0.75 [0.61–0.92; p<0.01]) in the upper quintile of leisure time PA had a lower risk of elevated resistin. In contrast, a high degree of sedentarism was associated with an increased risk elevated resistin in women (OR = 1.24 [1.04–1.47; p<0.05] and in men (OR = 1.40 [1.01–1.82; p<0.05]).ConclusionsIn our sample of the general population, resistin was inversely associated with measures and levels of PA and HDL cholesterol. The association of resistin with PA was stronger than the association of HDL cholesterol with PA, making resistin a potentially useful biomarker of PA.

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“…In Indian men, serum resistin levels are positively correlated with very low density lipoprotein (VLDL) cholesterol and triglyceride levels but negatively correlated with high density lipoprotein cholesterol levels [51]. In contrast, other studies have shown that resistin is inversely correlated with low density lipoprotein (LDL) cholesterol levels [52,53]. It has been suggested that resistin is positively correlated with atherogenic smaller and denser LDL subclasses in subjects with T2DM [54] and a recent study showed that the treatment of human hepatocytes with resistin potently stimulated the secretion of VLDL apolipoprotein B (apoB) and lipids as well as increased hepatocyte lipid content [55].…”

Section: Role Of Human Resistin In Atherogenic Dyslipidemiamentioning

confidence: 99%

Linking resistin, inflammation, and cardiometabolic diseases

Park

Kwak

Kim

et al. 2017

Korean J Intern Med

172

144

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Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. While resistin was first known as an adipocyte-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents, it is predominantly expressed and secreted by macrophages in humans. Epidemiological and genetic studies indicate that increased resistin levels are associated with the development of insulin resistance, diabetes, and cardiovascular disease. Resistin also appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and the formation of foam cells. Thus, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with cardiovascular disease and heart failure. Furthermore, recent evidence suggests that resistin is associated with atherogenic dyslipidemia and hypertension. The present review will focus on the role of human resistin in the pathogeneses of inflammation and obesity-related diseases.

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Relationships between Serum Resistin and Fat Intake, Serum Lipid Concentrations and Adiposity in the General Population

Cited by 35 publications

References 40 publications

Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease

Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease

Inverse association of resistin with physical activity in the general population

Linking resistin, inflammation, and cardiometabolic diseases

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