Relationships of low serum vitamin D3 with anthropometry and markers of metabolic syndrome and diabetes in overweightand obesity

McGill, Anne-Thea; Stewart, Jeanne W; Lithander, Fiona E; Strick, Christine A.; Poppitt, Sally D.

doi:10.14341/2071-8713-4887

Cited by 105 publications

(146 citation statements)

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“…However, the present results showed the amount of visceral or abdominal fat, reflected by the waist measurement (Pajuelo et al, 2004), and the waist/height ratio (Ashwell et al, 1996a, b) to be greater in the ID than in the AD subjects, whereas no differences were observed between these groups in terms of the amount of subcutaneous fat, as reflected by the tricipital skinfold thickness and the sum of tricipital and bicipital skinfold thickness (Tables 2 and 4). This result is similar to that reported by McGill et al (2008) in adults; these researchers also found an inverse relationship between waist measurement and serum vitamin D levels (r ¼ À0.14, P ¼ 0.03). The present results suggest that it is the amount of visceral and not subcutaneous fat that determines the serum level of vitamin D in children.…”

Section: Discussionsupporting

confidence: 91%

“…This threshold was the 90th percentile for the serum 25(OH)D concentration in the present population and was chosen as the most beneficial concentration for metabolic health because it is thought to be 70-100 nmol/l (Talwar et al, 2007;Vieth et al, 2007;McGill et al, 2008) and it is also in accordance with different studies that have defined as vitamin D insufficiency values from o25 nmol/l to o80 nmol/l (Rovner and O'Brien, 2008).…”

Section: Anthropometric Surveymentioning

confidence: 87%

“…This partly explains the high percentage (90.2%) who showed serum 25(OH)D concentrations of o70 nmol/l (that is, below the minimum value recommended for the maintenance of good metabolic health and considered as insufficient; Talwar et al, 2007;Vieth et al, 2007;McGill et al, 2008). This finding agrees with that reported in other studies with children, the researchers of which indicate that irrespective of whether their country is sunny, children's exposure to the sun would seem to be low and the dietary intake of vitamin D inadequate (Gordon et al, 2008;Mark et al, 2008;Bener et al, 2008a, b).…”

Section: Discussionmentioning

confidence: 99%

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Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish schoolchildren

et al. 2010

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Background/Objectives: To analyze the association between different anthropometric variables and vitamin D status in a group of Spanish schoolchildren. Subjects/Methods: Study subjects were 102 children aged 9-13 years. Records were made of their height, body weight, body mass index (BMI), waist and hip measurements (to determine the quantity of visceral or abdominal fat), and the thickness of the tricipital and bicipital skinfold (to determine the quantity of subcutaneous fat). Diets were analyzed using a 3-day weighed food record and vitamin D intakes compared with those recommended. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured using chemiluminescent assay. Results: The mean serum 25(OH)D concentration was 49.6 ± 15.9 nmol/l. The mean serum 25(OH)D in the ID subjects (that is, those with insufficient vitamin D levels, 25(OH)D of o70 nmol/l) was 46.6 ± 13.4 nmol/l and in the AD subjects (that is, those with adequate vitamin D levels, 25(OH)D of X70 nmol/l) was 77.5 ± 8.4 nmol/l (Po0.001). No significant difference was observed between both groups in vitamin D intake. However, the ID subjects had higher body weight, BMI, waist measurement and waist/height ratio than the AD subjects. Using a multiple linear regression analysis, only weight and BMI were found to independently influence 25(OH)D values. Children with a body weight, BMI, bicipital skinfold thickness, waist measurement and waist/height ratio above the 50th percentile for each variable were at a greater risk of having a low serum 25(OH)D concentration (o70 nmol/l). Conclusions: BMI and abdominal obesity influence the appearance of vitamin D insufficiency in children.

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Section: Discussionsupporting

confidence: 91%

Section: Anthropometric Surveymentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish schoolchildren

et al. 2010

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“…[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Some of the most recent information about low vitamin D status and obesity comes from studies in bariatric surgery patients, reporting low preoperative circulating levels of 25-hydroxyvitamin D. [21][22][23][24][25][26][27][33][34][35][36][37][38] In fact, a recent systematic review of 14 studies with about 1500 patients undergoing bariatric surgical procedures confirmed that obese individuals have serum 25-hydroxyvitamin D levels below 80 nmol l À1 preoperatively. 39 Other investigators have reported that body mass index (BMI) 25,26,[40][41][42][43][44][45][46] and body fat 20,45,[47][48][49]…”

Section: Methodsmentioning

confidence: 99%

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

et al. 2011

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Obesity and vitamin D deficiency have both been recognized as major public health issues worldwide, and there is growing evidence that they are related, although the cause-effect relationship remains unclear. Could obesity be contributing to low circulating 25-hydroxyvitamin D concentrations? Alternatively, could low vitamin D status predispose to obesity? In this review, the relationship between low circulating 25-hydroxyvitamin D and obesity, and possible underlying reasons from both perspectives, is presented. One potential mechanism by which obesity could contribute to low serum 25-hydroxyvitamin D is adipose sequestration of vitamin D. On the other hand, adipose tissue has both the vitamin D receptor and the ability to synthesize 1,25-dihydroxyvitamin D, and there is evidence that vitamin D may regulate adipose tissue mass, differentiation and metabolism in ways that might contribute to obesity. Of particular interest, vitamin D deficiency is common both before and after bariatric surgery, and is often difficult to treat, particularly with the more malabsorptive procedures. Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.

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“…Among these effects, several studies in adults suggest a link between vitamin D and cardiovascular disease risk (2-4), diabetes or HbA1c levels (5,6), hypertension (7)(8)(9)(10), and dyslipidemia (4). Reduced circulating 25-hydroxyvitamin D (25(OH)D) concentrations were found to be associated with higher fasting serum glucose (11,12), reduced insulin sensitivity (13)(14)(15), increased risk of type 2 diabetes (5,16,17) and either increased risk (18,19) or no effect on the metabolic syndrome (MetS) (20,21). On the other hand, results from interventional studies are controversial, showing either no effect of vitamin D supplementation on the risk of developing diabetes (22) or an attenuation of the increase in glycemia and insulin resistance that occur over time (23).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

Gannagé‐Yared¹,

Chedid²,

Khalife³

et al. 2009

European Journal of Endocrinology

157

133

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Objectives: Several studies suggest a link between circulating 25-hydroxyvitamin D (25(OH)D) and metabolic risk factors. However, this relation has been mainly studied in elderly and/or obese subjects. In addition, the relation between 25(OH)D and adiponectin is unclear. The purpose of this study is to look at these relations in non-obese young individuals. Design: We investigated the relation between serum 25(OH)D and adiposity, blood pressure, glucose metabolism, lipid profile, and adiponectin in 381 randomly selected university students (201 males and 180 females, mean age 23.9G3.9). Results: In the overall population, 25(OH)D is significantly inversely correlated with body mass index (BMI), systolic blood pressure (SBP), waist circumference (WC), fasting plasma glucose (FPG), insulin levels, and homeostasis model assessment of insulin resistance (HOMA index) and positively correlated with adiponectin and high density lipoprotein-cholesterol (P!0.01 for all variables). In males, these correlations are still significant for BMI, SBP, WC, and adiponectin (PZ0.02, PZ0.01, PZ0.04 and PZ0.01 respectively); also, 25(OH)D is inversely correlated with low density lipoprotein (LDL)-cholesterol (PZ0.007). In females, 25(OH)D is only inversely correlated with FPG and HOMA index (P!0.001 and PZ0.03 respectively). In multivariate regression analysis models, after adjustment for sex and BMI, 25(OH)D is an independent predictor of FPG and SBP (PZ0.032 and PZ0.05 respectively) in the overall population, while in males 25(OH)D is a predictor of LDL-cholesterol and SBP independently of BMI (PZ0.007 and PZ0.035 respectively). Conclusion: In non-obese young subjects, we observe new relationships between 25(OH)D and several metabolic risk factors and adiponectin. Further research is needed to elucidate the gender differences and to look at the relation between 25(OH)D and adiponectin.European Journal of Endocrinology 160 965-971

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Relationships of low serum vitamin D3 with anthropometry and markers of metabolic syndrome and diabetes in overweightand obesity

Cited by 105 publications

References 0 publications

Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish schoolchildren

Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish schoolchildren

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

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