Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

Sawada, Yu; Honda, Tetsuya; Hanakawa, Sho; Nakamizo, Satoshi; Murata, Takaho; Ueharaguchi-Tanada, Yuri; Ono, Sachiko; Amano, Wataru; Nakajima, Saeko; Egawa, Gyohei; Tanizaki, Hideaki; Otsuka, Atsushi; Kitoh, Akihiko; Dainichi, Teruki; Ogawa, Narihito; Kobayashi, Yuichi; Yokomizo, Takehiko; Arita, Makoto; Nakamura, Motonobu; Miyachi, Yoshiki; Kabashima, Kenji

doi:10.1084/jem.20150381

Cited by 93 publications

(96 citation statements)

References 33 publications

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“…In ChemR23 receptor‐deficient mice, Mp recruitment was sharply reduced in zymosan‐induced peritonitis (Cash et al, ). Similarly, RvE1 also inhibits dendritic cell migration in the skin and attenuates inflammatory responses (Sawada et al, ), as ChemR23 receptors are abundantly expressed in dendritic cells (Arita et al, ).…”

Section: Discussionmentioning

confidence: 99%

Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice

Liu

Shen

et al. 2017

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice

Liu

Shen

et al. 2017

British J Pharmacology

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“…Dermatitis in Pla2g2d Ϫ/Ϫ Mice-In a model of CHS, application of the hapten antigen dinitrofluorobenzene (DNFB) to abdominal skin (sensitization) followed by a second application of the same antigen to ear skin (elicitation) elicits Th1-driven ear swelling (13). We have recently shown that, in the elicitation phase of CHS, the resolution of a pro-inflammatory Th1 response in the skin and regional LNs is markedly delayed in Pla2g2d Ϫ/Ϫ mice (12).…”

Section: Aggravated Ln Inflammation In the Late Stage Of Irritantmentioning

confidence: 99%

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer

Miki

Kidoguchi

Sato

et al. 2016

Journal of Biological Chemistry

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Phospholipase A 2 enzymes have long been implicated in the promotion of inflammation by mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they also contribute to anti-inflammatory or pro-resolving programs. Group IID-secreted phospholipase A 2 (sPLA 2 -IID) is abundantly expressed in dendritic cells in lymphoid tissues and resolves the Th1 immune response by controlling the steady-state levels of anti-inflammatory lipids such as docosahexaenoic acid and its metabolites. Here, we show that psoriasis and contact dermatitis were exacerbated in Pla2g2d-null mice, whereas they were ameliorated in Pla2g2d-overexpressing transgenic mice, relative to littermate wild-type mice. These phenotypes were associated with concomitant alterations in the tissue levels of 3 polyunsaturated fatty acid (PUFA) metabolites, which had the capacity to reduce the expression of pro-inflammatory and Th1/Th17-type cytokines in dendritic cells or lymph node cells. In the context of cancer, however, Pla2g2d deficiency resulted in marked attenuation of skin carcinogenesis, likely because of the augmented anti-tumor immunity. Altogether, these results underscore a general role of sPLA 2 -IID as an immunosuppressive sPLA 2 that allows the microenvironmental lipid balance toward an anti-inflammatory state, exerting beneficial or detrimental impact depending upon distinct pathophysiological contexts in inflammation and cancer.

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“…4B). Indeed, ω3 PUFA-derived resolvins suppress acquired immunity by dampening DC migration and antigen presentation to T cells (Sawada et al, 2015). Furthermore, administration of a PLA2G2D-Fc fusion protein to mice prevents experimental autoimmune encephalomyelitis and colitis (von Allmen et al, 2009).…”

Section: Contact Hypersensitivitymentioning

confidence: 99%

The Roles of the Secreted Phospholipase A2 Gene Family in Immunology

Murakami

Yamamoto

Miki

et al. 2016

Advances in Immunology

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Within the phospholipase A (PLA) family that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, secreted PLA (sPLA) enzymes comprise the largest group containing 11 isoforms in mammals. Individual sPLAs exhibit unique tissue or cellular distributions and enzymatic properties, suggesting their distinct biological roles. Although PLA enzymes, particularly cytosolic PLA (cPLAα), have long been implicated in inflammation by driving arachidonic acid metabolism, the precise biological roles of sPLAs have remained a mystery over the last few decades. Recent studies employing mice gene-manipulated for individual sPLAs, in combination with mass spectrometric lipidomics to identify their target substrates and products in vivo, have revealed their roles in diverse biological events, including immunity and associated disorders, through lipid mediator-dependent or -independent processes in given microenvironments. In this review, we summarize our current knowledge of the roles of sPLAs in various immune responses and associated diseases.

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Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

Cited by 93 publications

References 33 publications

Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice

Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice

Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer

The Roles of the Secreted Phospholipase A2 Gene Family in Immunology

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