Salt-responsive gut commensal modulates TH17 axis and disease

Wilck, Nicola; Matus, Mariana; Kearney, Sean M.; Olesen, Scott W.; Forslund, Kristoffer; Bartolomaeus, Hendrik; Haase, Stefanie; Mähler, Anja; Balogh, András; Markó, Lajos; Vvedenskaya, Olga; Kleiner, Friedrich H.; Tsvetkov, D; Klug, Lars; Costea, Paul Igor; Sunagawa, Shinichi; Maier, Lisa; Rakova, Natalia; Schatz, Valentin; Neubert, Patrick; Frätzer, Christian; Krannich, Alexander; Gollasch, Maik; Grohme, Diana A.; Côrte-Real, Beatriz F.; Gerlach, Roman G.; Basic, Marijana; Typas, Athanasios; Wu, Chuan; Titze, Jens; Jantsch, Jonathan; Boschmann, Michael; Dechend, Ralf; Kleinewietfeld, Markus; Kempa, Stefan; Bork, Peer; Linker, Ralf A.; Alm, Eric J.; Müller, Dominik N.

doi:10.1038/nature24628

Cited by 912 publications

(849 citation statements)

References 75 publications

Supporting

Mentioning

781

Contrasting

Unclassified

Order By: Relevance

“…bacteria colonization [62]. L. murinus in host intestinal could modulate the Th17 cells and is vital in the formation of some autoimmune diseases [46]. Moreover, gut commensals protect the intestinal against pathogenic microbes by maintaining gut integrity and regulating intestinal barrier permeability [63].…”

Section: Discussionmentioning

confidence: 99%

“…And the study by sequencing the V4 region of 16S ribosomal RNA gene found that HSD increased the Firmicutes/Bacteroidetes ratio, that is, increased the abundances of gen-DOI: 10.1159/000493096 era Lachnospiraceae and Ruminococcus (p < 0.05) but decreased the abundance of Lactobacillus (p < 0.05) [26]. As the onset of Lactobacillus depletion is quick and remarkable, the Lactobacillus murinus is the most strongly associated with HSD [46]. This study also found that reducing intestinal survival of Lactobacillus spp.…”

Section: Hsd Alters the Gut Microbiota Profilingmentioning

confidence: 99%

“…This study also found that reducing intestinal survival of Lactobacillus spp. after high salt challenge would increase pathogenic Th17 cells [46], increase blood pressure [46], and increase colitis in mice [26].…”

Section: Hsd Alters the Gut Microbiota Profilingmentioning

confidence: 99%

See 2 more Smart Citations

High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu

Sun

Guo

et al. 2018

Digestion

View full text Add to dashboard Cite

Background: Gastrointestinal (GI) diseases are known to be largely influenced by one’s lifestyle and dietary uptake. A high-salt diet (HSD) is well recognized as a risk factor for cardiovascular complications, hypertension, and metabolic syndromes. However, the relationship between an HSD and the GI system, which is the compartment that comes in direct contact with exogenous stimulants, has not been fully explored. Aims: We seek to better understand the complexity of the pathogenic effects of an HSD in the context of GI disorders. Methods: By searching the PubMed and Web of science, the review of literature was performed using keywords: high-salt and GI, high-salt and immunity, salt and microbiota, salt and hormone. Results: In this review, we concluded that high-salt intake potentially perturbs the local immune homeostasis, alters the gut microbiota composition and function, and affects the endocrine hormone profiling in the GI system. Conclusion: HSD might get involved in GI diseases through the reshaping of gastroenterological milieu, which could help to better understand the complexity of the pathogenic effects of an HSD in the context of GI disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Hsd Alters the Gut Microbiota Profilingmentioning

confidence: 99%

See 1 more Smart Citation

High-Salt Diet Gets Involved in Gastrointestinal Diseases through the Reshaping of Gastroenterological Milieu

Sun

Guo

et al. 2018

Digestion

View full text Add to dashboard Cite

show abstract

“…Accordingly, angiotensin-II induced vascular inflammation, systolic blood pressure, and end organ damage were attenuated in germ-free mice as compared to conventionally-raised controls [65]. A recent study by Wilck and coworkers, including mouse and human data, has linked high salt intake to the depletion of Lactobacillus murinus, which was associated with an increase in CD4 + Rorγt + T H 17 cells and increased blood pressure [71]. Furthermore, gut dysbiosis has been suggested to be causally related to obstructive sleep apnea-induced hypertension [72].…”

Section: The Association Of Commensal Microbiota With Cardiovascularmentioning

confidence: 99%

The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease

2018

View full text Add to dashboard Cite

Commensal gut microbiota have recently been implicated in cardiovascular disease (CVD) and cerebrovascular disease. Atherosclerotic plaque formation depends on the colonization status of the host. In addition to host nutrition and the related microbiota-dependent metabolic changes, activation of innate immune pathways triggers the development of atherosclerosis and supports arterial thrombosis. Gnotobiotic mouse models have uncovered that activation of Toll-like receptor-2 by gut microbial ligands supports von Willebrand factor-integrin mediated platelet deposition to the site of vascular injury. Depending on nutritional factors, the microbiota-derived choline-metabolite trimethylamine Noxide (TMAO) increases atherosclerotic plaque size, triggers prothrombotic platelet function and promotes arterial thrombus growth. Hence, the composition of the commensal microbiota is an emerging risk factor for CVD. Here, we provide an overview on microbiota-dependent pathomechanisms that drive the development of CVD and arterial thrombosis.Keywords: Arterial thrombosis r Atherosclerosis r Cardiovascular disease r Microbiota r Toll-like receptors IntroductionAt birth, our body surfaces are colonized by microbial communities (microbiota), representing one of the most densely colonized microbial ecosystems [1]. This process is strongly influenced by genetic, nutritional, and environmental factors [2]. The commensal microbiota constitutes a permanent inflammatory stimulus [3], which is kept in check by the host's immune responses [4]. The microbiota can be viewed as an organ that impacts host physiology [5,6]. Changes in gut microbiota composition were associated with intestinal diseases (e.g. inflammatory bowel disease, colon cancer) and cardiometabolic disease states, such as diet-induced obesity, type 2 diabetes, atherosclerosis, and arterial thrombosis [7]. The results from recent experimental and clinical studies have led to the assumption that Correspondence: Christoph Reinhardt e-mail: Christoph.Reinhardt@unimedizin-mainz.de molecules synthesized by the intestinal microbiota are involved in the development of cardiovascular disease (CVD) [8] and may increase the risk of arterial thrombosis [9, 10] as well as the outcome of ischemic stroke [11]. Experimental evidence from germ-free mouse studies and metagenomics analyses have associated the gut microbiota with obesity [12][13][14][15], type 2 diabetes [3, 16, 17], stroke [11, 18], and CVD [8, 9, 19]. Therefore, targeting the composition and metabolic function of the intestinal microbiota may represent a therapeutic option that in the future may allow prevention and treatment of cardiometabolic diseases [20].Here, we provide a comprehensive overview on the emerging link between gut microbiota and CVD. We delineate the contribution of this complex microbial ecosystem to metabolic inflammation and its impact on host metabolism. The main focus of this review is to highlight how gut microbiota may contribute to the development of CVD, cerebrovascular disease and arterial thromb...

show abstract

“…In the context of C. difficile infection, the pathological composition of the microbiota can be changed significantly by fecal microbiota transplantation, and thus, the potentially lethal disease can be treated much more effectively compared to the standard treatment to date. There is also a close link between compositional and functional microbiome variations and several lifestyle diseases such as obesity [3], decreased insulin resistance [4], high blood pressure [5] and coronary heart disease. In the case of obesity and reduced insulin resistance, impressive "therapeutic" effects by fecal microbiome transplantation could be shown recently.…”

mentioning

confidence: 99%