Skin anti-aging strategies

Gancevičienė, Rūta; Liakou, Aikaterini I.; Theodoridis, A; Makrantonaki, Evgenia; Zouboulis, Christos C.

doi:10.4161/derm.22804

Cited by 591 publications

(482 citation statements)

References 177 publications

(128 reference statements)

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“…According to Farage et al [12], skin ageing occurs inevitably as a consequence of physiological changes over time due to genetic factors and changes in cell metabolism and the tissue structure [13][14][15][16]. Intrinsic or chronological ageing is the term used to characterize these natural changes.…”

Section: Introductionmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

127

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Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers. The occurrence of UV radiation-induced alternative splicing of the elastin gene, which leads to inadequate synthesis of the proteins required for the correct assembly of elastic fibers, is a potential explanation for this phenomenon. Innovative studies have been fundamental for the elucidation of rarely explored photoaging mechanisms and have enabled the identification of effective therapeutic alternatives such as cosmetic products. This review addresses cutaneous photoaging and the changes that affect elastin in this process.R esum e Le vieillissement de la peau est un processus complexe qui peutêtre caus e par des facteurs intrins eques et extrins eques du corps. Les rayons ultraviolets (UV) repr esentent l'une des principales sources de dommages de la peau au fil des ans et caract erise un processus connu sous le nom de photo-vieillissement. Parmi les changements qui affectent le tissu cutan e avec l'âge, la perte des propri et es elastiques caus ees par des changements dans la production d' elastine, augmentation de la d egradation et / ou le traitement, produit un impact important sur l'esth etique et la sant e des tissus. La survenue d'une elastose solaire est l'un des principaux marqueurs de photo-vieillissement cutan e et se caract erise par un d epôt d esordonn e et non-fonctionnel des fibres elastiques. L'apparition d'un epissage alternatif du g ene de l' elastine induit par le rayonnement UV, ce qui conduit a une synth ese insuffisante des prot eines n ecessaires a l'assemblage correct des fibres elastiques, est une explication possible de ce ph enom ene. Des etudes novatrices ont et e fondamentales pour l' elucidation des m ecanismes de photovieillissement rarement explor es et ont permis l'identification d'alternatives th erapeutiques efficaces, tels que les produits cosm etiques. Cette revue porte sur le photo-vieillissement cutan e et les changements qui affectent l' elastine dans ce processus.

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Section: Introductionmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

127

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“…Kırışıklık önleyici ve yüz gerdirici aktif bileşenlerdendirler 58 . Bileşimindeki palmitoil oligopeptit tek başına kozmetik bileşeni olarak temizleyici ve cilt düzenleyici iken palmitoil oligopeptit-70 emoliyan, tırnak ve cilt düzenleyici olarak belirtilmektedir 28 . Dermaxyl™; palmitoil oligopeptitve seramit 2 kombinasyonu olup yapılan çalışmalar bileşimde bulunan matrikinlerin, yapısal olarak bozulmuş ve onarılmaya ihtiyacı olan hücreleri kendisine çekerek onardığını, seramitlerin ise cilt bariyerinin güçlenmesine ve onarımına yardımcı olduğunu, su tutulmasını artırarak, cilt kuruluğunu azalttığını göstermiştir 59 .…”

Section: Doğal Veya Sentetik Kökenli Peptitler Ve Türevleriunclassified

Anti-Aging Cosmetics Approaches and Components in Products

Yapar¹,

Tanrıverdi²

2016

BSBD

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Cilt yaşlanması; iç veya dış faktörlerin veya bunların birlikteliğinin neden olduğu karmaşık biyolojik bir süreçtir. Gelişen üretim teknolojileri, farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ve yenilikçi bileşenlere dayalı yeni nesil kozmetik ürünler, temel kozmetik bakımdan ileri alternatifler sunmaktadır. İleri teknoloji kullanılarak üretilen kozmetik aktif bileşenleri, doğal kaynaklı hammaddelerin kozmetik bileşenleri olarak kullanımının artması ve farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ile geliştirilen kozmetik ürünler toplumların artan kozmetik beklentilerini karşılamayı hedeflemektedir. Bu derlemede, günümüzde bireylerin dış ve iç faktörler ile artan cilt yaşlanmasının, kozmetik ürün odaklı çözümleri özellikle bileşenler açısından irdelenmiş, yaşlanma karşıtı farklı yaklaşımlar özetlenmiş ve kullanılan taşıyıcı sistemler belirtilmiştir.

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“…Antioxidants may delete premature brown spots and other signs of skin degraded by sunlight. Antioxidants may erase the signs of aging skin and protect the skin cancer (Ganceviciene et al, 2012).…”

Section: The Network Antioxidantsmentioning

confidence: 99%

One Can Slow Down the Aging through Antioxidants

Aversa¹,

Petrescu²,

Apicella³

et al. 2016

American Journal of Engineering and Applied Sciences

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Free radicals are natural nanoparticles which are doing their part well defined in the human cell, but then they must be annihilated or eliminated to not destroy the cell or another part of our body. It has been shown that residual free radicals in the body are responsible for the aging. The role to annihilate them is ful-filled by the antioxidants. Antioxidants are a group of compounds produced by the organism or that occur naturally in many foods. Antioxidants work together in the human body to maintain health and vigor, especially during the last decades of life. They do this by protecting us from harm caused by free radicals that can destroy skin and tissues healthy cells of the organism. Antioxidants are chemical compounds with many and varied applications. Naturally present in our diet, through fruits, vegetables, tea or red wine, they are recognized to be good for health. In fact, antioxidants protect our body's proteins and nucleic acids from oxidation. In the industry, antioxidants are also used as food additives to increase the shelf life of food. They are also present in the packaging or the wheels of cars because they prevent synthetic materials from becoming crumbly and brittle. Finally, in the cosmetics industry, creams containing antioxidants are known for their anti-aging properties. An antioxidant is a molecule that decreases or prevents the oxidation of other chemicals. Oxidation is part of an oxidation-reduction reaction that transfers electrons from a substance to an oxidizing agent. This reaction can produce radicals that cause destructive chain reactions. However, whatever the field of application, the unstable nature of antioxidants is a problem: The molecules degrade rapidly and have a particularly limited power of action over time.

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Skin anti-aging strategies

Cited by 591 publications

References 177 publications

Elastin structure and its involvement in skin photoageing

Elastin structure and its involvement in skin photoageing

Anti-Aging Cosmetics Approaches and Components in Products

One Can Slow Down the Aging through Antioxidants

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