Sociocultural Influences in Genetic Designs of Aging: Unexplored Perspectives

Abstract

As the aging population continues to become more diverse, there is growing interest in understanding the similar and unique aspects of aging within and across people of different ethnic groups. The impact of culture on the sources of variation identified in quantitative genetic approaches has not been well discussed in the literature. The purpose of this paper is to review previous research pertinent to the cultural aspects of quantitative genetic approaches and methodologies, and provide conceptual and statistical approaches for advancing the science. To meet this objective, results from previously published studies as well as preliminary data analyses from the Carolina African American Twin Study of Aging will be presented. There are three themes to draw from the issues discussed in this paper: (1) avoiding genetic reductionism, (2) interpreting differential heritabilities, and (3) modeling cultural influences.

Studying Biobehavioral Aspects of Health Disparities Among Older Adult Minorities

“…However, recent research on the multifactorial nature of risks for disease processes demonstrate genetic and environmental influences that are both important. This is perhaps our best indicator that science must avoid a reductionistic view (Whitfield et al 16 ). In particular, the role of genetics in the origin of racial health disparities is receiving growing attention and has been susceptible to considerable misinterpretation.…”

Experiences and Expectations of Ethnic Minorities and Majorities towards Community Pharmacy Medicines-Related Services in Estonia

“…Several previous studies have shown that ethnic majorities have a more positive health profile than minorities and that the difference is particularly marked among the elderly [5,6]. Moreover, the assessment of social and cultural determinants of health is complex and often requires consideration of the ethnicity, geographical location, genetic background and exposure to the environment of a particular population group [1,7,8].…”

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Biobehavioral Aspects on Late-Life Morbidities

“…Much of the previous research has focused on the behaviors and social structures that produce differences in health and disease across ethnic groups. Recent research on the multifactorial nature of risks for disease processes that demonstrate genetic and environmental infl uences are both important, is perhaps our best indicator that science must avoid a reductionistic view (see Whitfi eld, Brandon, & Wiggins, 2002). Sickle cell is just one example of a genetically determined disease but modifi ed by the environment.…”