State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study

Rosenbaum, David; Hagen, Katja; Deppermann, Saskia; Kroczek, Agnes; Haeußinger, Florian B.; Berg, Daniela; Fallgatter, Andreas J.; Metzger, Florian; Ehlis, Ann‐Christine

doi:10.1016/j.neurobiolaging.2015.11.022

Cited by 38 publications

(36 citation statements)

References 75 publications

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“…As expected from our previous findings 6 and the observed anti-correlation between CCN and DMN 20 , we found reduced FC within regions of the DMN in the depressed sample compared to the non-depressed sample. These findings are in line with other studies that found disrupted FC in MDD between posterior and temporal areas 21 , posterior cortex and bilateral caudate 22 , in inter-hemispheric FC 23 , in the salience network 24 and between functional connectivity networks 25 .…”

Section: Discussionsupporting

confidence: 91%

“…Higher FC in MDD and LLD in parts of the Cognitive Control Network (CCN) and the Default Mode Network (DMN) have often been interpreted as manifestations of depression-specific processes 5, 6 . Especially the DMN – which anatomically consists of the precuneus, adjacent posterior cingulate/retrospinal cortex, the inferior parietal lobe/AngG (angular gyrus) and the medial prefrontal cortex 7 – has been proposed to play a role in depressive rumination, due to its importance for self-referential processes.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant functional connectivity in depression as an index of state and trait rumination

Rosenbaum

Haipt

Fuhr

et al. 2017

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Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Aberrant functional connectivity in depression as an index of state and trait rumination

Rosenbaum

Haipt

Fuhr

et al. 2017

Sci Rep

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“…In contrast to fMRI, a higher temporal resolution is possible (sampling rate is 10 Hz). fNIRS is very suitable for investigating paradigms associated with cognition [22], but also functional connectivity using resting-state measurements [23]. Additionally, fNIRS is a suitable and well accepted method for elderly and/or cognitively impaired subjects.…”

Section: Introductionmentioning

confidence: 99%

“…The Benton Line orientation task assesses visuoconstruction and clearly differentiates AD patients and controls [24]. The Trail Making test is a common test used to evaluate executive functions, and requires only slight modification to the paper-and-pencil version in the fNIRS setting [23, 25]. The Verbal Fluency Task (VFT) investigates language abilities as well as executive functions, and is therefore often used in different neuropsychological test batteries examining cognitive functions in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Brain activation in frontotemporal and Alzheimer’s dementia: a functional near-infrared spectroscopy study

et al. 2016

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BackgroundFrontotemporal dementia is an increasingly studied disease, the underlying functional impairments on a neurobiological level of which have not been fully understood. Patients with the behavioral-subtype frontotemporal dementia (bvFTD) are particularly challenging for clinical measurements such as functional imaging due to their behavioral symptoms. Here, an alternative imaging method, functional near-infrared spectroscopy (fNIRS), is introduced to measure task-related cortical brain activation based on blood oxygenation. The current study investigated differences in cortical activation patterns of patients with bvFTD, Alzheimer’s dementia (AD), and healthy elderly subjects measured by fNIRS.MethodEight probable bvFTD patients completed the semantic, phonological, and control conditions of a verbal fluency task. Eight AD patients and eight healthy controls were compared on the same task. Simultaneously, an fNIRS measurement was conducted and analyzed using a correction method based on the expected negative correlation between oxygenated and deoxygenated hemoglobin.ResultsHealthy controls show an increase in cortical activation measured in frontoparietal areas such as the dorsolateral prefrontal cortex. The activation pattern of patients with AD is similar, but weaker. In contrast, bvFTD patients show a more frontopolar pattern, with activation of Broca’s area, instead of the dorsolateral prefrontal cortex and the superior temporal gyrus. The frontoparietal compensation mechanisms, seen in the healthy elderly, were missing in bvFTD patients.ConclusionDifferent frontoparietal cortical activation patterns may indicate a correlate of diverse pathophysiological mechanisms of AD and bvFTD during verbal fluency processing. The AD pattern is weaker and more similar to the healthy pattern, whereas the bvFTD pattern is qualitatively different, namely more frontopolar and without frontoparietal compensation activation. It adheres to a change of cortical activation during the course of the disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s13195-016-0224-8) contains supplementary material, which is available to authorized users.

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“…fNIRS has been implemented in the form of a wearable device capable of intuitively monitoring brain activity in real-life conditions28, it has shown promise over the past few decades to support rsFC studies in both healthy individuals27 and psychiatric patients1516 with depression29, attention deficit/hyperactive disorder30, and autism31, suggesting that alterations in rsFC strength has potential as a biomarker to examine different psychiatric disorder trajectories. Recently, the use of fNIRS to assess functional connectivity has been extended to psychiatric patients with arachnophobia32 and children with psychopathology risk33.…”

mentioning

confidence: 99%

Abnormal resting-state functional connectivity in the orbitofrontal cortex of heroin users and its relationship with anxiety: a pilot fNIRS study

Ieong¹,

Yuan²

2017

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Drug addiction is widely linked to the orbitofrontal cortex (OFC), which is essential for regulating reward-related behaviors, emotional responses, and anxiety. Over the past two decades, neuroimaging has provided significant contributions revealing functional and structural alternations in the brains of drug addicts. However, the underlying neural mechanism in the OFC and its correlates with drug addiction and anxiety still require further elucidation. We first presented a pilot investigation to examine local networks in OFC regions through resting-state functional connectivity (rsFC) using functional near-infrared spectroscopy (fNIRS) from eight abstinent addicts in a heroin-dependent group (HD) and seven subjects in a control group (CG). We discovered that the HDs manifested enhanced interhemispheric correlation and rsFC. Moreover, small-worldness was explored in the brain networks. In addition to the altered rsFC in the OFC networks, our examinations demonstrated associations in the functional connectivity between the left inferior frontal gyrus and other OFC regions related to anxiety in the HDs. The study provides important preliminary evidence of the complex OFC networks in heroin addiction and suggests neural correlates of anxiety. It opens a window in application of fNIRS to predict psychiatric trajectories and may create new insights into neural adaptations resulting from chronic opiate intake.

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State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study

Cited by 38 publications

References 75 publications

Aberrant functional connectivity in depression as an index of state and trait rumination

Aberrant functional connectivity in depression as an index of state and trait rumination

Brain activation in frontotemporal and Alzheimer’s dementia: a functional near-infrared spectroscopy study

Abnormal resting-state functional connectivity in the orbitofrontal cortex of heroin users and its relationship with anxiety: a pilot fNIRS study

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