Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities

Rosmond, Roland

doi:10.1210/jc.83.6.1853

Cited by 590 publications

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“…A possible mechanism behind abdominal obesity and depression may be stress. [42][43][44][45] A possible physiological mechanism behind abdominal obesity and depression may be cortisol secretion, which is regulated by the hypothalamic-pituitaryadrenal axis. 42,43 Increased levels of cortisol have been observed during stress 44 and depression.…”

Section: Discussionmentioning

confidence: 99%

“…[42][43][44][45] A possible physiological mechanism behind abdominal obesity and depression may be cortisol secretion, which is regulated by the hypothalamic-pituitaryadrenal axis. 42,43 Increased levels of cortisol have been observed during stress 44 and depression. 45 As a way to cope with stress some individuals are prone to consume alcohol Obesity and depression A Herva et al and to eat unhealthy foods, 22 which is associated with abdominal obesity 35 and depression.…”

Section: Discussionmentioning

confidence: 99%

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Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study

et al. 2005

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Objective: To examine the association between body size and depression in a longitudinal setting and to explore the connection between obesity and depression in young adults at the age of 31 years. Design: This study forms part of the longitudinal Northern Finland 1966 Birth Cohort Study (N ¼ 12 058). The follow-up studies were performed at 14 and 31 years. Data were collected by postal inquiry at 14 years and by postal inquiry and clinical examination at 31 years. Subjects: A total of 8451 subjects (4029 men and 4422 women) who gave a written informed consent and information on depression by three depression indicators at 31 years. Measurements: Body size at 14 (body mass index (BMI) and 31 (BMI and waist-to-hip ratio (WHR)) years and depression at 31 years by three different ways: depressive symptoms by the HSCL-25-depression questionnaire (HSCL-25), the use of antidepressants and self-reported physician-diagnosed depression. Results: Obesity at 14 years associated with depressive symptoms at 31 years; among male subjects using the cutoff point 2.01 in the HSCL-25 (adjusted odds ratio (OR) 1.97, 95% CI 1.06-3.68), among female subjects using the cutoff point 1.75 (adjusted OR 1.64, 95% CI 1.16-2.32). Female subjects who were obese both at baseline and follow-up had depressive symptoms relatively commonly (adjusted OR 1.40, 95% CI 1.06-1.85 at cutoff point 1.75); a similar association was not found among male subjects. The proportion of those who used antidepressants was 2.17-fold higher among female subjects who had gained weight compared to female subjects who had stayed normal-weighted (adjusted OR 2.17, 95% CI 1.28-3.68). In the crosssectional analyses male subjects with abdominal obesity (WHR X85th percentile) had a 1.76-fold risk of depressive symptoms using the cutoff 2.01 in the HSCL-25 (adjusted OR 1.76, 95% CI 1.08-2.88). Abdominally obese male subjects had a 2.07-fold risk for physician-diagnosed depression (adjusted OR 2.07, 95% CI 1.23-3.47) and the proportion of those who used antidepressants was 2.63-fold higher among obese male subjects than among male subjects without abdominal obesity (adjusted OR 2.63, 95% CI 1.33-5.21). Abdominal obesity did not associate with depression in female subjects. Conclusion: Obesity in adolescence may be associated with later depression in young adulthood, abdominal obesity among male subjects may be closely related to concomitant depression, and being overweight/obese both in adolescence and adulthood may be a risk for depression among female subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study

et al. 2005

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“…Therefore, it is possible that elevated plasma TTR levels (possibly derived from pancreas) prevent the renal clearance of RBP4, leading to insulin resistance. Furthermore, stress and glucocorticoids associated with increased insulin resistance are also known to induce TTR expression in liver and choroids plexus (33,34). Interestingly, renal failure associated with increase in plasma RBP4 levels was also reported to be linked with insulin resistance (35).…”

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 2 Diabetesmentioning

confidence: 99%

Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: The significance of transthyretin

et al. 2012

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SummaryRetinol-binding protein 4 (RBP4) is the principle carrier of retinol in the human plasma, which circulates as a complex with transthyretin (TTR), a homotetrameric thyroxine transport protein. Although this complex formation is thought to prevent glomerular filtration of RBP4, it also stabilizes the quaternary structure of TTR. Recent studies indicate elevated plasma levels of RBP4 in type 2 diabetes (T2D). In contrast, reduced RBP4 levels were observed in type 1 diabetes (T1D). Herein, we critically examine the probable mechanisms involved in the regulation of RBP4 and TTR levels during T2D and T1D. The available evidences point to the involvement of pancreatic factors in regulating the expression of both RBP4 and TTR. It appears that during T1D, TTR levels are reduced and it exists predominantly as a monomer that may interfere its interaction with RBP4 resulting in its loss through glomerular filtration. However, plasma TTR levels remain high under T2D conditions and thus reducing glomerular filtration of RBP4. Therefore, the plasma TTR levels appear to be an important determinant of plasma RBP4 levels in these two diabetic conditions. 2012 IUBMB IUBMB Life, 64(12): 975-982, 2012

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“…Studies of men with high variability of cortisol secretion (indicating normal regulation of the HPA) have shown that cortisol secretion is positively associated with blood testosterone and fasting insulin levels, whereas in men with low variability of diurnal cortisol secretion (indicating abnormal regulation of the HPA axis), cortisol secretion shows strong negative relationships with testosterone and insulin (Rosmond, Dallman, & Björntorp, 1998). In line with this, our results indeed showed that cortisol was associated negatively with fasting insulin and positively with testosterone levels among these physically prefrail and frail older persons, possibly indicating a more sensitive effect on insulin–leptin axis dysregulation than anabolic testosterone dysregulation.…”

Section: Introductionmentioning

confidence: 99%

Dysregulated homeostatic pathways in sarcopenia among frail older adults

Choo

et al. 2018

Aging Cell

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Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia. We used 40 blood biomarkers belonging to community‐dwelling prefrail and frail older persons to derive measures of multiple physiological pathways, and structural equation modeling to generate path network models of the multisystem physiological dysregulations associated with muscle mass and function (MMF). Insulin–leptin signaling and energy regulation, anabolic sex steroid regulation (testosterone, leptin), and tissue oxygenation (hemoglobin, red cell count) appear to be primary mediating factors exerting direct influences on MMF. There was additionally secondary mediatory involvement of myocyte‐ and adipocyte‐derived cytokines, hypothalamic pituitary adrenal (HPA) stress hormones (cortisol, DHEAS), glomerular function, and immune cell regulatory and inflammatory cytokines and glycoproteins. We conclude that within a hierarchical network of multisystem physiological dysregulations in sarcopenia, dysregulated anabolic and catabolic pathways via sex steroids and insulin–leptin dual signaling and tissue hypoxemia are primary physiological dysregulations responsible for sarcopenia and frailty.

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Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities

Cited by 590 publications

References 0 publications

Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study

Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study

Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: The significance of transthyretin

Dysregulated homeostatic pathways in sarcopenia among frail older adults

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