The brain and the stress axis: The neural correlates of cortisol regulation in response to stress

Dedovic, Katarina; Duchesne, Annie; Andrews, Julie; Engert, Veronika; Pruessner, Jens C.

doi:10.1016/j.neuroimage.2009.05.074

Cited by 521 publications

(368 citation statements)

References 98 publications

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“…Moreover, other investigators have found changes in the physiological and behavioral indicators that are characteristic of the global response to stress following an acute painful stimulus, which include (but are not limited to) autonomous, metabolic, and behavioral changes (18)(19) . Due to the specific nature and duration of ophthalmoscopy, it does not seem probable that a single intervention might suffice to reduce the associated pain (7) .…”

Section: Discussionmentioning

confidence: 99%

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Human milk for neonatal pain relief during ophthalmoscopy

Ribeiro

Castral²,

Montanholi

et al. 2013

Rev. esc. enferm. USP

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RESUMOO exame de fundo de olho para o diagnós-tico precoce da retinopatia da prematuridade causa dor no prematuro, sendo necessárias intervenções que a minimizem. O objetivo foi investigar a efetividade do leite humano para alívio da dor em prematuros submetidos ao exame de fundo de olho para diagnóstico precoce da doença, em comparação com a sacarose. Tratou-se de um estudo piloto de caráter quase experimental, realizado com 14 prematuros internados na unidade neonatal de um hospital universitário. Na comparação entre os grupos, não houve diferença estatística significativa relacionada à duração do tempo de choro, concentração do cortisol salivar e frequência cardíaca. O leite humano parece ser tão efetivo quanto a sacarose no alívio da dor aguda relacionada ao exame. Tem-se como limitação o tamanhoreduzido da amostra e a falta de randomização. É necessária a realização de estudos experimentais com maior poder amostral para fortalecer as evidências encontradas. DESCRITORES ABSTRACTOphthalmoscopy performed for the early diagnosis of retinopathy of prematurity (ROP) is painful for preterm infants, thus necessitating interventions for minimizing pain. The present study aimed to establish the effectiveness of human milk, compared with sucrose, for pain relief in premature infants subjected to ophthalmoscopy for the early diagnosis of ROP. This investigation was a pilot, quasi-experimental study conducted with 14 premature infants admitted to the neonatal intensive care unit (NICU) of a university hospital. Comparison between the groups did not yield a statistically significant difference relative to the crying time, salivary cortisol, or heart rate (HR). Human milk appears to be as effective as sucrose in relieving acute pain associated with ophthalmoscopy. The study's limitations included its small sample size and lack of randomization. Experimental investigations with greater sample power should be performed to reinforce the evidence found in the present study. DESCRIPTORSPain Infant, premature Milk, human Retinopathy of prematurity Maternal-child nursing RESUMENEl examen de fondo de ojo para el diagnós-tico precoz de retinopatía prematura causa dolor en el prematuro, siendo necesarias intervenciones que la minimicen. El objetivo fue investigar la efectividad de la leche humana para el alivio del dolor en los prematuros sometidos al examen de fondo de ojo para el diagnóstico precoz de la enfermedad, en comparación con la sacarosa. Estudio piloto de carácter cuasi-experimental, realizado con 14 prematuros internados en la unidad neonatal de un hospital universitario. En la comparación entre los grupos, no hubo diferencia estadística significativa relacionada a la duración del tiempo del llanto, la concentración del cortisol salival y la frecuencia cardiaca. La leche humana parece ser tan efectiva como la sacarosa en el alivio del dolor agudo debido al examen. Una limitación fue el reducido tamaño de la muestra y la falta de aleatorización. Es necesaria la realización de estudios experimentales con mayor tamaño de...

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Section: Discussionmentioning

confidence: 99%

“…Cortisol affects the metabolism, cardiovascular system, and central nervous system (19) . Salivary cortisol has been used in studies to assess the effects of non-pharmacological interventions against pain in newborn infants, including sucrose, the kangaroo position, and developmental care (20)(21)(22) .…”

Section: Discussionmentioning

confidence: 99%

Human milk for neonatal pain relief during ophthalmoscopy

Ribeiro

Castral²,

Montanholi

et al. 2013

Rev. esc. enferm. USP

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“…Analysis of salivary cortisol levels demonstrated that the fatigue manipulation indeed elicited a stress response, indexed by relatively elevated cortisol levels, in a group of 15 responders out of the total 27 participants. Studies using psychological stress paradigms have similarly reported the categorization of around 50% of participants as responders (Dedovic, Duchesne, Andrews, Engert, & Pruessner, 2009). Inspection of cortisol levels throughout the test session showed that cortisol levels increased further after participants entered the scanner, indicating that the scanner itself may also have contributed to the stress response (Muehlhan, Lueken, Wittchen, & Kirschbaum, 2011).…”

Section: Discussionmentioning

confidence: 99%

Cortisol and induced cognitive fatigue: Effects on memory activation in healthy males

Klaassen¹,

Groot²,

Evers³

et al. 2013

Biological Psychology

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a b s t r a c tWe investigated the relationship between individual differences in acute fatigue and endogenous cortisol changes elicited by the sustained performance of cognitively demanding tasks (fatigue condition). Healthy males provided salivary cortisol measurements and subjective fatigue ratings, and were scanned (functional magnetic resonance imaging) during memory encoding and recognition tasks in fatigue and control conditions. A group of 15 'responders' showed significantly higher cortisol levels in the fatigue condition than 12 'non-responders'. Responders showed higher subjective fatigue and reduced encoding and recognition activation than non-responders in the fatigue condition. An interaction in activation changes in the right hippocampus during encoding reflected decreased activation in responders, but somewhat increased activation in non-responders in the fatigue compared to control condition. Moreover, decreased hippocampal activation in responders was associated with increased subjective fatigue. Findings are consistent with a central role for the hippocampus in differences between responders and non-responders and also implicate the right hippocampus in individual differences in induced cognitive fatigue effects.

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“…Moreover, we propose that the antidepressant‐like effects of knockout of Hint1 in mice represent the genotype rather than the stress effect. The HPA axis commonly dysfunctions under stress conditions, and is involved in mood disorders (Dedovic, Duchesne, Andrews, Engert, & Pruessner, 2009; Jo, Zhang, Emrich, & Dietrich, 2015; Schule, Baghai, Eser, & Rupprecht, 2009). The finding of a trend toward anxiolytic‐like effects in the elevated anxiety‐like behavior in Hint1 ‐KO mice after CIS indicates that CIS plays an important role in changes in anxiety‐related behaviors, and that the underlying mechanism may involve activation of the HPA axis by stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of Hint1 deficiency on emotional‐like behaviors in mice under chronic immobilization stress

Sun

Liu

et al. 2017

Brain and Behavior

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BackgroundHistidine triad nucleotide‐binding protein 1 (HINT1) is regarded as a haplo‐insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender‐specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain‐derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss.MethodsThis study examined the role of HINT1 deficiency in anxiety‐related and depression‐like behaviors and BDNF expression in the hippocampus under chronic immobilization stress, and investigated whether the sex‐specific and haplo‐insufficient effects exist in emotional‐like behaviors under the same condition.ResultsIn a battery of behavior tests, the results of the control group, not exposed to stress, showed that knockout (KO) and heterozygosity (HT) of Hint1 had anxiolytic‐like and antidepression‐like effects on the male and female mice. However, both male and female Hint1‐KO mice showed elevated anxiety‐related and antidepression‐like behavior under chronic immobilization stress; moreover, both male and female Hint1‐HT mice displayed elevated anxiety‐related behavior and increased depression‐like behavior under chronic immobilization stress. There were no significant differences in general locomotor activity between Hint1‐KO and ‐HT mice and their wild‐type (WT) littermates. Hint1‐KO mice under basal and chronic immobilization stress conditions expressed more BDNF in the hippocampus than did Hint1‐HT and WT mice; overall, there were no significant sex differences in emotional‐like behaviors of Hint1‐KO and ‐HT mice. Additionally, Hint1‐HT mice showed haplo‐insufficient effects on emotional‐like behaviors under basic conditions, rather than under chronic immobilization stress.ConclusionsBoth male and female HINT 1 KO and HT mice had a trend of anxiolytic‐like behavior and antidepression‐like behavior at control group. However, both male and female HINT1 KO mice showed elevated anxiety‐related and antidepression‐like behavior under chronic immobilization stress; moreover, both male and female HINT1 HT mice displayed elevated anxiety‐related behavior and increased depression‐like behavior under chronic immobilization stress.

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The brain and the stress axis: The neural correlates of cortisol regulation in response to stress

Cited by 521 publications

References 98 publications

Human milk for neonatal pain relief during ophthalmoscopy

Human milk for neonatal pain relief during ophthalmoscopy

Cortisol and induced cognitive fatigue: Effects on memory activation in healthy males

Effects of Hint1 deficiency on emotional‐like behaviors in mice under chronic immobilization stress

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