The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics

Heidbreder, Christian; Groenewegen, Henk J.

doi:10.1016/j.neubiorev.2003.09.003

Cited by 750 publications

(710 citation statements)

References 210 publications

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“…2b, Deacon et al, 1983;Sesack et al, 1989). The medial prefrontal cortex is usually subdivided into four regions: the medial precentral, anterior cingulate, prelimbic and infralimbic cortices and together these areas are involved in working memory, attention, control of emotional and planning (Heidbreder and Groenewegen, 2003). All four of these subregions of the medial prefrontal cortex project to the perirhinal cortex (Heidbreder and Groenewegen, 2003) though it is mainly the more rostral structures (prelimbic and infralimbic cortices as well as the rostral regions of the anterior cingulate cortex) that project to the perirhinal cortex (Jones and Witter, 2007).…”

Section: Cortical Projectionsmentioning

confidence: 99%

“…The medial prefrontal cortex is usually subdivided into four regions: the medial precentral, anterior cingulate, prelimbic and infralimbic cortices and together these areas are involved in working memory, attention, control of emotional and planning (Heidbreder and Groenewegen, 2003). All four of these subregions of the medial prefrontal cortex project to the perirhinal cortex (Heidbreder and Groenewegen, 2003) though it is mainly the more rostral structures (prelimbic and infralimbic cortices as well as the rostral regions of the anterior cingulate cortex) that project to the perirhinal cortex (Jones and Witter, 2007). Jones and Witter (2007) also suggest that there is a topographic distinction between the different medial prefrontal regions; the anterior cingulate, prelimbic and infralimbic all project to the perirhinal and lateral entorhinal cortices whereas the other areas project mainly to the postrhinal and medial entorhinal cortices (see Section 4 for the implications of such topographic delineation).…”

Section: Cortical Projectionsmentioning

confidence: 99%

“…Here the perirhinal cortex plays more of an associative role compared to its role in recognition memory (Kholodar-Smith et al, 2008b). Based on the anatomical projections described in Sections 3.2 and 3.3, it is not surprising that the perirhinal cortex is required for such associational learning as it forms a significant reciprocal connections with the amygdala Price, 1974, 1977;Ottersen, 1982;McDonald and Jackson, 1987;Pitkä nen et al, 2000;Pikkarainen and Pitkä nen, 2001;Furtak et al, 2007b), thalamus (Cornwall and Phillipson, 1988;Wouterlood et al, 1990;Shibata, 1993;McIntyre et al, 1996;Van Groen et al, 1999;Vertes et al, 2006), medial prefrontal cortex (Deacon et al, 1983;Sesack et al, 1989;Burwell and Amaral, 1998b;Delatour and Witter, 2002;Heidbreder and Groenewegen, 2003;Jones and Witter, 2007;Agster and Burwell, 2009) and hippocampus (Swanson and Cowan, 1977;Deacon et al, 1983;Kosel et al, 1983;Van Groen and Wyss, 1990;McIntyre et al, 1996;Naber et al, 1999;Shi and Cassell, 1999;Witter et al, 1999;Kloosterman et al, 2003b); regions of the brain which have been strongly linked with fear conditioning (Milad et al, 2006;Rosen and Donley, 2006).…”

Section: The Role Of the Perirhinal Cortex In Fear Conditioningmentioning

confidence: 99%

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The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Kealy

Commins

2011

Progress in Neurobiology

102

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Section: Cortical Projectionsmentioning

confidence: 99%

Section: Cortical Projectionsmentioning

confidence: 99%

Section: The Role Of the Perirhinal Cortex In Fear Conditioningmentioning

confidence: 99%

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The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Kealy

Commins

2011

Progress in Neurobiology

102

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“…Several reports have also suggested its crucial role in working memory [9,10] . The mPFC in rat consists of four main subdivisions, the medial agranular, anterior cingulate (AC), prelimbic (PL) and infralimbic cortices [10][11][12] . inactivation of the ventral mPFC (PL and AC cortices), produces marked deficits in delayedresponse tasks involving short or long delays [13][14][15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Bai

Liu

et al. 2012

Neurosci. Bull.

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Objective Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role.This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Methods Sprague-Dawley rats were trained in a Y-maze until they reached an 80% correct rate in a working memory task. Then a 16-channel microelectrode array was implanted in the prefrontal cortex. After recovery, neuronal population activity was recorded during the task, using the Cerebus data-acquisition system. Spatio-temporal trains of action potentials were obtained from the original neuronal population signals. Results During the Y-maze working memory task, some neurons showed significantly increased firing rates and evident neuronal ensemble activity. Moreover, the anticipatory activity was associated with the delayed alternate choice of the upcoming movement. In correct trials, the averaged pre-event firing rate (10.86 ± 1.82 spikes/ bin) was higher than the post-event rate (8.17 ± 1.15 spikes/bin) (P <0.05). However, in incorrect trials, the rates did not differ. Conclusion The results indicate that the anticipatory activity of a neuronal ensemble in the prefrontal cortex may play a role in encoding working memory events.

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“…The ratio of TRP and these other LNAAs (TRP/ΣLNAA ratio) is thought to be a more sensitive index of brain tryptophan availability than plasma TRP (Fernstrom 1981;Wurtman et al 1980) because this ratio determines the amount of tryptophan that can enter the brain. Moreover, 5-HT and 5-HIAA concentrations were measured in the frontal cortex and the hippocampus, the brain regions involved in cognition and memory (Dalley et al 2004;Heidbreder and Groenewegen 2003;Squire and Zola-Morgan 1991;Wurtman et al 1980). …”

Section: Introductionmentioning

confidence: 99%

Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats

et al. 2008

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Rationale Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. Objectives As individual differences exist in central serotonin neurotransmission, the impact of ATD may vary accordingly. In this experiment, we investigated the hypothesis that male serotonin transporter knockout (SERT −/− ), rats marked by a lower SERT function, are more vulnerable to the effects of ATD in an object recognition task than male wildtype (SERT +/+ ) and heterozygous (SERT +/− ) rats. Materials and methods Twelve male SERT +/+ , SERT +/− , and SERT −/− rats were treated with standard dose and lowdose ATD using a gelatine-based protein-carbohydrate mixture lacking tryptophan. In the control treatment, Ltryptophan was added to the mixture. Four hours after treatment, the rats were subjected to the object recognition task. In addition, the effects of ATD on plasma amino acid concentrations were measured, and concentrations of 5-HT and 5-HIAA were measured in the frontal cortex and hippocampus of these rats. Results Plasma TRP levels and central 5-HT and 5-HIAA levels were decreased in all genotypes after ATD, but effects were stronger in SERT −/− rats. The standard dose of ATD impaired object recognition in all genotypes. SERT −/− and SERT +/− rats were more vulnerable to low dose of ATD in the object recognition task compared to SERT +/+ rats. Conclusions These results indicate a greater sensitivity to ATD in SERT −/− and SERT +/− rats, which may be related to stronger central depletion effects in these rats.

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The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics

Cited by 750 publications

References 210 publications

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats

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