Tissue metabolomic fingerprinting reveals metabolic disorders associated with human gastric cancer morbidity

Hu, Song; Wang, Lei; Liu, Huanliang; Wu, Xiaobin; Wang, Huashe; Liu, Zhonghui; Li, Yun; Diao, Dechang; Chen, Honglei; Peng, Junsheng

doi:10.3892/or.2011.1302

Cited by 27 publications

(16 citation statements)

References 38 publications

(46 reference statements)

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“…Lactate, threonine, acetate, uracil, succinate, lysine and tyrosine, myo-inositol, taurine and creatine have been shown to be associated with the presence of rectal cancer, and correlated with its progression (79). Taurine is also increased in squamous-cell carcinoma (80), while lactate has additionally been shown to be associated with oesophago-gastric cancer (81), along with fumurate, valine, glutamine, glutamate (81), xylonic acid (81, 82), tyrosine, phenylalanine, and tryptophan (83). Together these metabolites indicate a general dysregulation in the metabolism of cellular respiration, energy, amino acids, ketone body and choline metabolism which, as discussed, could be applicable to all cancers.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Kelly

Heiden

Giovannucci

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

109

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Metabolite profiling is being increasing employed in the study of prostate cancer as a means of identifying predictive, diagnostic and prognostic biomarkers. This review provides a summary and critique of the current literature. Thirty-three human case-control studies of prostate cancer exploring disease prediction, diagnosis, progression or treatment response were identified. All but one demonstrated the ability of metabolite profiling to distinguish cancer from benign, tumor aggressiveness, cases who recurred, and those who responded well to therapy. In the subset of studies where biomarker discriminatory ability was quantified, high AUCs were reported that would potentially outperform the current gold standards in diagnosis, prognosis and disease recurrence, including PSA testing. There were substantial similarities between the metabolites and the associated pathways reported as significant by independent studies, and important roles for abnormal cell growth, intensive cell proliferation and dysregulation of lipid metabolism were highlighted. The weight of the evidence therefore suggests metabolic alterations specific to prostate carcinogenesis and progression that may represent potential metabolic biomarkers. However, replication and validation of the most promising biomarkers is currently lacking and a number of outstanding methodological issues remain to be addressed in order to maximize the utility of metabolomics in the study of prostate cancer.

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Section: Methodological Considerationsmentioning

confidence: 99%

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Kelly

Heiden

Giovannucci

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

109

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“…Amongst the most significantly altered metabolites, malonate, and serine were specific to esophageal cancer; 3-hydroxypropionate and pyruvate for gastric cancer and alanine, glutamine, and glucuronic lactone for CRC. Very recently, Song et al (2011a,b) applied metabolomics to both sera and tissues biopsies to investigate biomarkers of gastric cancer that could help predicting carcinogenesis and metastasis at an early stage. Their analysis of biopsies using a GC–MS approach provided a set of 15 metabolites associated with the gastric cancer morbidity (Song et al, 2011a).…”

Section: Clinical Applications For Cancer Diagnosismentioning

confidence: 99%

“…Very recently, Song et al (2011a,b) applied metabolomics to both sera and tissues biopsies to investigate biomarkers of gastric cancer that could help predicting carcinogenesis and metastasis at an early stage. Their analysis of biopsies using a GC–MS approach provided a set of 15 metabolites associated with the gastric cancer morbidity (Song et al, 2011a). This metabolic signature encompassed significant alterations of glycolysis, fatty acid oxidation, cholesterol, and amino acid metabolism (Song et al, 2011a).…”

Section: Clinical Applications For Cancer Diagnosismentioning

confidence: 99%

“…Their analysis of biopsies using a GC–MS approach provided a set of 15 metabolites associated with the gastric cancer morbidity (Song et al, 2011a). This metabolic signature encompassed significant alterations of glycolysis, fatty acid oxidation, cholesterol, and amino acid metabolism (Song et al, 2011a). A similar approach was applied to monitor serum metabolic composition of gastric cancer patients, which confirmed these metabolic alterations in addition to nucleotide metabolism at systemic level (Song et al, 2011b).…”

Section: Clinical Applications For Cancer Diagnosismentioning

confidence: 99%

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Metabolomic Applications to Decipher Gut Microbial Metabolic Influence in Health and Disease

Martin¹,

Collino²,

Rezzi³

et al. 2012

Front. Physio.

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Dietary preferences and nutrients composition have been shown to influence human and gut microbial metabolism, which ultimately has specific effects on health and diseases’ risk. Increasingly, results from molecular biology and microbiology demonstrate the key role of the gut microbiota metabolic interface to the overall mammalian host’s health status. There is therefore raising interest in nutrition research to characterize the molecular foundations of the gut microbial–mammalian cross talk at both physiological and biochemical pathway levels. Tackling these challenges can be achieved through systems biology approaches, such as metabolomics, to underpin the highly complex metabolic exchanges between diverse biological compartments, including organs, systemic biofluids, and microbial symbionts. By the development of specific biomarkers for prediction of health and disease, metabolomics is increasingly used in clinical applications as regard to disease etiology, diagnostic stratification, and potentially mechanism of action of therapeutical and nutraceutical solutions. Surprisingly, an increasing number of metabolomics investigations in pre-clinical and clinical studies based on proton nuclear magnetic resonance (1H NMR) spectroscopy and mass spectrometry provided compelling evidence that system wide and organ-specific biochemical processes are under the influence of gut microbial metabolism. This review aims at describing recent applications of metabolomics in clinical fields where main objective is to discern the biochemical mechanisms under the influence of the gut microbiota, with insight into gastrointestinal health and diseases diagnostics and improvement of homeostasis metabolic regulation.

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“…Organic acids may also be of use as novel biomarkers to predict disease progression, the response to treatment and prognosis. However, only a few reports on metabolic profiling of gastric cancer tissue have been published, and these reports have involved few patients [11], [12]. Although several methods, such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), for the quantitative measurement of metabolites have been developed, gas chromatography (GC) coupled with mass spectrometry (MS) has become the gold standard for the analysis of small molecular weight metabolites due to its high sensitivity and reproducibility [13].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Measurement of Organic Acids in Tissues from Gastric Cancer Patients Indicates Increased Glucose Metabolism in Gastric Cancer

et al. 2014

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The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study is to investigate the levels of organic acids in cancerous and normal tissues from gastric cancer patients and to confirm the role of metabolic alterations in gastric carcinogenesis. Organic acids in normal and cancerous tissues from forty-five patients with gastric adenocarcinoma were investigated by gas chromatography-mass spectrometry in selected ion monitoring mode as methoxime/tert-butyldimethylsilyl derivatives. We analysed the significant differences in the levels of organic acids in normal and cancer tissues and investigated the correlation of these levels in cancer tissues with clinicopathological features. The levels of Krebs cycle components, including α-ketoglutaric acid, succinic acid, fumaric acid, malic acid and oxaloacetic acid, were significantly increased in cancer tissues compared to normal tissues. In addition, the levels of glycolytic products, including pyruvic acid and lactic acid, as well as the levels of ketone bodies, including 3-hydroxybutyric acid, were also significantly increased in cancer tissues compared to normal tissues. The levels of ketone bodies in cancer tissues with differentiated histology and in intestinal-type cancer tissues were significantly increased. The organic acid profiling analysis described here may be a generally useful clinical tool for understanding the complexity of metabolic events in gastric adenocarcinoma, and organic acids may have potential as metabolic markers for the future discovery of diagnostic and therapeutic modalities.

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Tissue metabolomic fingerprinting reveals metabolic disorders associated with human gastric cancer morbidity

Cited by 27 publications

References 38 publications

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Metabolomic Applications to Decipher Gut Microbial Metabolic Influence in Health and Disease

Quantitative Measurement of Organic Acids in Tissues from Gastric Cancer Patients Indicates Increased Glucose Metabolism in Gastric Cancer

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