Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice
Dan Qiu,
Tong Liu,
Wei Qianping
Abstract:ObjectiveThis study aimed to explore the molecular mechanism underlying the role of Pin1 in cognitive dysfunction in diabetic mice.MethodsUsing a streptozotocin‐induced diabetic mouse model, an adeno‐associated virus carrying the Pin1 gene was used to upregulate Pin1 expression in the hippocampus of diabetic mice. Animal behavior tests and molecular biology techniques were further used to explore the role of Pin1 in cognitive dysfunction in diabetic mice.ResultsOur study demonstrated that upregulation of Pin1 … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.