Vitamin C in the Treatment and/or Prevention of Obesity

García-Díaz, Diego F.; Lopez-Legarrea, Patricia; Quintero, Pablo; Martínéz, J. Alfredo

doi:10.3177/jnsv.60.367

Cited by 84 publications

(57 citation statements)

References 103 publications

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“…In this sense, vitamin C could easily be included in the composition of commercially prepared foods or added to the diet as a supplement. Vitamin C may benefit all individuals, including nondiabetics (vitamin C control group) as found by the present and other studies [3][4][5] , reducing the amount of weight and visceral fat gain, normalizing BMI, and acting as a blood glucose-lowering agent.…”

Section: Discussionmentioning

confidence: 62%

“…At the same time, vitamin C effectively reduced visceral fat accumulation. These effects may be related to the antioxidant nature of vitamin C, as demonstrated by Garcia--Diaz et al 3 . In the present study, both lower weight gain and lower visceral fat in the group co-treated with vitamin C and invert sugar are similar to those of the control group.…”

Section: Discussionmentioning

confidence: 90%

“…The mechanisms by which vitamin C slows down weight gain have not been fully elucidated, but Garcia-Diaz et al 3 suggest that this beneficial effect may be associated with vitamin C ability to modulate adipocyte lipolysis, regulate the release of glucocorticoids by the adrenal glands, inhibit glucose metabolism and leptin release by isolated adipocytes, reduce hyperglycemia and glycosylation in obese-diabetic models, and reduce the inflammatory response. Carillon et al 30 pointed out that obesity induced by an inadequate diet may be associated with oxidative stress, reducing the antioxidant defenses and allowing vitamin C to act as a natural antioxidant, which helps to treat obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Sugary beverages increase appetite more than solid foods given the low satiety and incomplete compensation of fluid calories, being an important contributor to higher fat deposition 14,28 . Since vitamin C reduces weight and visceral fat gain 3,4 , it may have helped to reduce weight gain in the study rats.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Molz¹,

Rael

Fischer

et al. 2017

Rev. Nutr.

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Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.001) than groups vitamin C control and vitamin C plus invert sugar. Consequently, groups vitamin C control and vitamin C plus invert sugar had gained as little body mass index as group C by the end of the experiment. Vitamin C decreased the fasting glycemia of both groups supplemented with vitamin C and normalized the glucose tolerance of group vitamin C plus invert sugar, whose area under the curve matched that of group C. Conclusion: Vitamin C has anti-obesogenic and glycemia-lowering effects in Wistar rats, which might be promising to prediabetics. Future studies are needed to understand the anti-obesogenic and anti-hyperglycemic mechanisms of vitamin C in prediabetes.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Molz¹,

Rael

Fischer

et al. 2017

Rev. Nutr.

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“…A lack of vitamin C intake has also been associated with the incidence of chronic diseases such as obesity [16,17] whilst vitamin C supplementation has been shown to improve triglyceride accumulation [18] and endothelial function [19]. In order to improve vitamin C bioavailability and thus boost its beneficial effects, researchers have started to consider liposomal formulations as a good alternative to standard oral vitamin C supplementation.…”

Section: Liposomal Technology and Nutritionmentioning

confidence: 99%

Liposomal Nanotechnology - A New Frontier for Sport and Exercise Nutrition?

Higgins¹

2016

JNMR

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Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress

Beglaryan,

Hakobyan,

Nazaretyan

2023

Stress and Health

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The aim of this study was to determine whether ascorbic acid (AA) supplementation can lower plasma levels of Cortisol and dehydroepiandrosterone‐sulphate (DHEA‐S) in patients diagnosed with functional hypercortisolemia due to unspecified chronic stress. Study includes data from 69 female with elevations in the cortisol and DHEA‐S levels. Duration of follow‐up was 2 months. Patients were divided into 3 groups. Group I included patients 23 with elevated cortisol, Group II—patients 24 with elevated levels of both hormones, Group III‐ patients 22 with normal cortisol and increased DHEA‐S. Each group was randomly divided into two subgroups. The first subgroup was prescribed 1000 mg daily oral dose of AA. The diet of the second subgroup were left unaltered. All patients have their hormones levels re‐examined 2 months later. After 2 months of AA supplementation the mean levels of elevated plasma cortisol and DHEA‐S decreased. In Group I the level of cortisol fell from 780 ± 57–446 ± 26 nmol/L, p = 0.000065 in Group II from 657 ± 47–515 ± 29 nmol/L, p = 0.005. The elevated levels of DHEA‐S have also declined in patients from AA‐treated subgroups (from 13.9 ± 1.6–9.9 ± 1.2, p = 0.0007 in Group II, and from 12.8 ± 1.0–7.8 ± 1.4, p = 0.003 in Group III). In untreated subgroups changes in hormone levels were insignificant. The study shows that female patients with functional hypercortisolemia or elevated levels of DHEA‐S can be treated with AA to bring level of these hormones closer to a normal range.

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Vitamin C in the Treatment and/or Prevention of Obesity

Cited by 84 publications

References 103 publications

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

Liposomal Nanotechnology - A New Frontier for Sport and Exercise Nutrition?

Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress

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