What We Talk About When We Talk About Fat

Rosen, Evan D.; Spiegelman, Bruce M.

doi:10.1016/j.cell.2013.12.012

Cited by 1,850 publications

(1,725 citation statements)

References 303 publications

(335 reference statements)

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“…WAT, which consists of unilocular white adipocytes, is a major site of fat storage from which energy is mobilized in the form of triglycerides during nutrient deprivation. BAT is composed of specialized multilocular adipocytes that have higher numbers of mitochondria than unilocular white adipocytes; the multilocular adipocytes are involved in dissipating energy as heat during cold-or diet-induced thermogenesis by promoting the β-oxidation of fatty acids 79 . Recently, a third type of adipocyte was identified; called beige or brite adipocytes, these are brown-like adipocytes that are found in WAT 80 .…”

Section: Hepatic Steatosismentioning

confidence: 99%

Autophagy at the crossroads of catabolism and anabolism

Kaur

Debnath

2015

Nat Rev Mol Cell Biol

800

778

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Section: Hepatic Steatosismentioning

confidence: 99%

Autophagy at the crossroads of catabolism and anabolism

Kaur

Debnath

2015

Nat Rev Mol Cell Biol

800

778

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“…The AT, apart from storing energy, also plays an important role in immune response, mechanical protection, endocrine function, and thermoregulation (Rosen and Spiegelman 2014). Studies on rodents and humans showed that the body of a healthy, lean individual is composed of approximately 15-28 % fat mass (Avram et al 2005a) with low variance; however, a high-fat diet (HFD) induces obesity with a wide variability of fat mass accumulation as seen in some mouse genotypes (Moitra et al 1998;Hausman et al 2001;Koza et al 2006).…”

Section: Adipose Tissue and Obesitymentioning

confidence: 99%

Obesity and related consequences to ageing

Jura

Kozak

2016

AGE

298

172

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Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter. Here, we aimed to identify similarities underlying mechanisms related to both obesity and ageing. We bring together evidence that age-related changes in body fat distribution and metabolism might be key factors of a vicious cycle that can accelerate the ageing process and onset of age-related diseases.

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“…Therefore this hypoxic state is one of the early determinants of AT dysfunction (66) . Hypoxia inducible factor-1, which is a transcription factor induced by a hypoxic state can initiate in turn a profibrotic transcriptional programme (73) .…”

Section: Hypoxiamentioning

confidence: 99%

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

et al. 2014

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Evidence suggests that at a population level, childhood and adolescent obesity increase the long-term risk of chronic diseases such as type 2 diabetes and CVD. At an individual level, however, the metabolic consequences of obesity in youth vary immensely. Despite comparable BMI, some adolescents develop impaired glucose tolerance while others maintain normal glucose homeostasis. It has been proposed that the variation in the capacity to store lipid in the subcutaneous adipose tissue (SAT) may partially discriminate metabolically healthy from unhealthy obesity. In positive energy balance, a decreased capacity to expand SAT may drive lipid accumulation to visceral adipose tissue, liver and skeletal muscle. This state of lipotoxicity is associated with chronic low-grade inflammation, insulin resistance and dyslipidaemia. The present review examines the differential adipose tissue development and function in children and adolescents who exhibit metabolic dysregulation compared with those who are protected. Additionally, the role of manipulating dietary fat quality to potentially prevent and treat metabolic dysfunction in obesity will be discussed. The findings of the present review highlight the need for further randomised controlled trials to establish the effect of dietary n-3 PUFA on the metabolic phenotype of obese children and adolescents. Furthermore, using a personalised nutrition approach to target interventions to those at risk of, or those with established metabolic dysregulation may optimise the efficacy of modifying dietary fat quality.

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What We Talk About When We Talk About Fat

Cited by 1,850 publications

References 303 publications

Autophagy at the crossroads of catabolism and anabolism

Autophagy at the crossroads of catabolism and anabolism

Obesity and related consequences to ageing

Adipose tissue dysregulation and metabolic consequences in childhood and adolescent obesity: potential impact of dietary fat quality

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