Women With Synchronous Primary Cancers of the Endometrium and Ovary: Do They Have Lynch Syndrome?

Soliman, Pamela T.; Broaddus, Russell R.; Schmeler, Kathleen M.; Daniels, Molly S.; González, Delia Almeida; Slomovitz, Brian M.; Gershenson, David M.; Lu, Karen H.

doi:10.1200/jco.2005.03.5915

Cited by 97 publications

(65 citation statements)

References 20 publications

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“…Ovarian carcinomas that are Lynch syndrome-associated are usually of endometrioid or clear cell type. Some authors 72,73 have suggested that the presence of synchronous endometrioid carcinomas of the ovary and endometrium may be associated with microsatellite instability, but other studies 74,75 have not drawn this conclusion. Nine of 70 patients with endometrial carcinoma (13%) who were younger than 40 years had a synchronous ovarian tumor, most frequently of endometrioid type.…”

Section: Ovarian Conservationmentioning

confidence: 93%

Endometrial Carcinoma in Women Aged 40 Years and Younger

Garg

Soslow

2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Endometrial carcinoma is a disease of older postmenopausal women, and is relatively uncommon in patients younger than 40 years. Endometrial carcinomas in this age group may be familial, associated with Lynch syndrome, or sporadic.Objectives.-To present our current knowledge of endometrial carcinomas in women younger than 40 years.Data Sources.-The review is based on previously published articles on this topic.Conclusions.-Most endometrial carcinomas that occur in this age group are associated with estrogen excess. They are usually low-grade endometrioid carcinomas that present at low stages and are associated with favorable clinical outcomes. Tumors associated with mismatch repair abnormalities and Lynch syndrome appear to be distinct, with worse prognostic factors and, possibly, clinical behavior. Conservative hormonal therapy and ovarian conservation are reasonable considerations in the management of these young patients, but carry the risk of tumor progression, recurrence, and an occult synchronous or metachronous ovarian carcinoma.

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Section: Ovarian Conservationmentioning

confidence: 93%

Endometrial Carcinoma in Women Aged 40 Years and Younger

Garg

Soslow

2014

Archives of Pathology &Amp; Laboratory Medicine

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“…Hastalardaki klinik bulgular ve tanısal yöntemler yanında moleküler genetik çalışmalar ile MPK'lerin erkenden tanınmaları ve tedavileri mümkün olabilmektedir. Kemoterapi ile ilişkili tümörler temas (aerodigestif mukoza) ve absorpsiyon bölgeleri (gastrointestinal sistem) yanında metabolize olduğu (karaciğer) ve ekskrete edildiği (böbrek) yerlerde ortaya çıkmaktadır (75,76). Bu tümörler daha küçük çapta, daha agresif ve daha yüksek oranda erken metastaz yapma eğilimindedir.…”

Section: Multipl Primer Kanserlerde Tedavi Ve Prognozunclassified

Synchronous and Metachronous Secondary Tumors of Bladder Cancer Patients

Dirim¹,

Özkardeş²,

Hasırcı³

2016

uob

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GirişMultipl primer kanserler (MPK) ilk olarak 1889 yılında Billroth tarafından farklı histolojide, farklı organda ve farklı zaman aralığında ortaya çıkan tümörler olarak tanımlanmıştır (1). Bu tanımlama sistemi Warren ve Gates (2) tarafından 1932 yılında modifiye edilerek günümüzde kullanılan şeklini almıştır. Güncel tanımlamaya göre multipl primer tümörlerde olması gereken üç özellik (a) her tümörün klinik ve histolojik özellikleriyle malign olduğunun ortaya konulması; (b) her birinin histolojik olarak farklı tümörler olması; (c) herhangi bir tümörün diğerinin nüksü ya da metastazı olmadığının gösterilmesi şeklinde belirlenmektedir.İlk primer tümör genellikle indeks tümör olarak da adlandırılır. Çoklu primer tümörler senkron veya metakron tümörler olmak üzere iki grupta değerlendirilmektedir. Ancak senkron ve metakron tümör tanımı için bir uzlaşı söz konusu değildir. SEER (Surveillance, Epidemiology, and End Results) ölçütlerine göre ilk tümör tanısından itibaren iki ay içerisinde yeni tanı konmuş kanserler için senkron, iki aydan sonrası için metakron tanımının kullanılması önerilmektedir (3). İki aydan daha kısa sürede ortaya çıkan tümörler için bazı çalışmalarda simültane tümör terimi de kullanılmıştır (4). Moertel (5), yeni bir tanımlama getirerek ikincil tümör, indeks tümör tanısından itibaren altı ay içerisinde görülürse senkron, altı aydan sonra The improvements in cancer treatment prolonged survival in patients. Despite this survival benefit, chemotherapies, radiotherapies or combination therapies, and continuing exposure to the same carcinogenic agents may lead to secondary cancers. Multiple primary neoplasm is described as multiple tumors in a single patient posing distinct individual malignant characteristics with definite exclusion of one tumor is the metastasis of the other. According to the time of onset, these are considered to be synchronous or metachronous tumors. While synchronous tumors often occur due to carcinogen exposure, metachronous tumors often develop after treatments such as radiotherapy. Although the cause and developmental mechanisms of multiple primary tumors are not clear, several factors including immune deficiency, genetic instability, increased use of systemic chemotherapy and radiotherapy, increased survival, elderliness, and smoking have been implicated. The two developmental hypotheses in development of multiple primary tumors appear as field cancerization and common clonal origin. Multiple primary tumors often involve respiratory, gastrointestinal, and genitourinary systems. Transitional cell carcinoma of the urinary bladder may also rise as part of synchronous or metachronous multiple tumors. We still lack large scale studies relevant to the treatment of multiple primary cancers. Close follow-up in primary malignant tumor patients is of extreme importance for the risk of secondary cancers. Keywords: Multiple primary tumor, synchronous and metachronous tumors, secondary tumor, bladder cancer Kanser tedavisindeki gelişmeler kanserli hastalarda sağkalımı uzatmaktadır. Ancak...

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“…Bu hastalarda endometrium kanseri gelişme riski %40-60 iken over kanseri için bu risk %10-12'dir (15). Literatürde senkron endometrium-over kanserli hastalarda Lynch sendromu sıklığı %7-9 olarak bildirilirken (12,20) tüm bu hastaların 1. derece yakınlarında HNPCC ilişkili kanser hikayesi mevcuttur (20). Soliman ve ark.…”

Section: Introductionunclassified

“…Soliman ve ark. senkron endometrium-over kanserli hastaları içeren çalışmalarında olguların %7 sinde Lynch sendromu klinik veya moleküler özellikleri ile karşılaşmışlardır (20). Çalışmamızda 6 hastanın (% 23) birinci veya ikinci derece yakınında kanser hikayesi mevcuttur ancak hiçbir hastaya genetik çalışma yapılmamıştır.…”

Section: Introductionunclassified

Multi̇pl Pri̇mer Ji̇nekoloji̇k Tümörler

Özdemir¹,

Özer²,

Ergen³

et al. 2014

İst Tıp Fak D

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Results: The median age was 51 years (34-79 years). Coexistence of endometrial and ovary cancer was most common (61.5%). Other coexistence of malignancies were; endometrium-cervix (4 patients, 15.3%), cervix-ovary (3 patients, 11.5%), cervix-vagina (2 patients, 7.6%) and endometrium-over-cervix cancer (1 patient, 3.8%). The most common stage and grade were; stage1 and grade1. The most common complaint was abnormal vaginal bleeding. 5 year overall survival was 83% for endometrium-ovary group. Conclusion: Multiple primary gynecological cancer is not common in daily practice. Synchronous endometrial and ovarian cancer is the most common in this population. They have a good prognosis due to detection at a relatively early stage. When we consider the positive impact of early diagnosis for its prognosis, the risk of developing a secondary cancer always should be kept in mind in the presence of a primary malignancy and follow-up of these patients should be done carefully.

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Women With Synchronous Primary Cancers of the Endometrium and Ovary: Do They Have Lynch Syndrome?

Cited by 97 publications

References 20 publications

Endometrial Carcinoma in Women Aged 40 Years and Younger

Endometrial Carcinoma in Women Aged 40 Years and Younger

Synchronous and Metachronous Secondary Tumors of Bladder Cancer Patients

Multi̇pl Pri̇mer Ji̇nekoloji̇k Tümörler

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