α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 2. α-Glucosidase Inhibition by Isolated Acylated Anthocyanins

Matsui, Toshiro; Ueda, Tetsuya; Oki, Tomoyuki; Sugita, Koichi; Terahara, Norihiko; Matsumoto, Kiyoshi

doi:10.1021/jf0012502

Cited by 172 publications

(127 citation statements)

References 16 publications

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“…The inhibitory effect of the flavan-3-ol group was almost the same as that of tea polyphenols on the PNPG-hydrolytic activity (14). Acylated anthocyanins and anthocyanins inhibit rat small intestinal ␣-glucosidase with an IC50 of 60 M and 4.6 mM, respectively (15). In this work, a slight inhibitory activity of cyanidin was observed.…”

Section: Inhibition Of Rat Small Intestinal ␣-Glucosidase By Flavonoidssupporting

confidence: 63%

Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids

Tadera

Minami

Kouta

et al. 2006

J Nutr Sci Vitaminol

876

561

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SummaryThe inhibitory activity of six groups of flavonoids against yeast and rat small intestinal ␣ -glucosidases and porcine pancreatic ␣ -amylase was compared, and chemical structures of flavonoids responsible for the inhibitory activity were evaluated. Yeast ␣ -glucosidase was potently inhibited by the anthocyanidin, isoflavone and flavonol groups with the IC 50 values less than 15 M . The following structures enhanced the inhibitory activity: the unsaturated C ring, 3-OH, 4-CO, the linkage of the B ring at the 3 position, and the hydroxyl substitution on the B ring. Rat small intestinal ␣ -glucosidase was weakly inhibited by many flavonoids, and slightly by the anthocyanidin and isoflavone groups. 3-OH and the hydroxyl substitution on the B ring increased the inhibitory activity. In porcine pancreatic ␣ -amylase, luteolin, myricetin and quercetin were potent inhibitors with the IC 50 values less than 500 M . The 2,3-double bond, 5-OH, the linkage of the B ring at the 3 position, and the hydroxyl substitution on the B ring enhanced the inhibitory activity, while 3-OH reduced it.

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Section: Inhibition Of Rat Small Intestinal ␣-Glucosidase By Flavonoidssupporting

confidence: 63%

Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids

Tadera

Minami

Kouta

et al. 2006

J Nutr Sci Vitaminol

876

561

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“…It has also been suggested that coffee may prevent hyperglycaemia by interfering in different stages of glucose metabolism and glycaemic regulation [49]. For instance, inhibition or retardation of the action of a-glucosidase by chlorogenic acid is one of the most important mechanisms [50]. The inhibition of this enzyme is an effective approach to control of postprandial hyperglycaemia.…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption and risk of total and cardiovascular mortality among patients with type 2 diabetes

Bidel

Qiao

et al. 2006

Diabetologia

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Aims/hypothesis Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association between coffee consumption and CVD mortality among patients with type 2 diabetes. Methods We prospectively followed 3,837 randomly ascertained Finnish patients with type 2 diabetes aged 25 to 74 years. Coffee consumption and other study parameters were determined at baseline. The International Classification of Diseases was used to identify CHD, CVD and stroke cases using computerised record linkage to the national Death Registry. The associations between coffee consumption at baseline and risk of total, CVD, CHD, and stroke mortality were analysed by using Cox proportional hazards models. Results During the average follow-up of 20.8 years, 1,471 deaths were recorded, of which 909 were coded as CVD, 598 as CHD and 210 as stroke. The respective multivariateadjusted hazard ratios in participants who drank 0-2, 3-4, 5-6, and Q7 cups of coffee daily were 1.00, 0.77, 0.68 and 0.70 for total mortality (P<0.001 for trend), 1.00, 0.79, 0.70 and 0.71 for CVD mortality (P=0.006 for trend), 1.00, 0.78, 0.70 and 0.63 for CHD mortality (p=0.01 for trend), and 1.00, 0.77, 0.64 and 0.90 for stroke mortality (p=0.12 for trend). Conclusions/interpretation In this large prospective study we found that in type 2 diabetic patients coffee drinking is associated with reduced total, CVD and CHD mortality.

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“…α-Glucosidase, which is a membrane-bound enzyme located in the epithelium of the small intestine, catalyzes the cleavage of glucose from disaccharides. A recent study 4,5 indicated that the 'Ayamurasaki' anthocyanins YGM-3 and YGM-6 displayed potent α-glucosidase (maltase) inhibitory activities with IC 50 values of 200 µM, which were more than 5 times higher than that of D-xylose (IC 50 = 1,190 µM). In a study in rats 6 , when the 'Ayamurasaki' anthocyanin YGM-6 (100 mg/kg) was administered following maltose (2 g/kg), the maximal blood glucose level at 30 min significantly decreased by 16.5% compared to the control group.…”

Section: Antimutagenic Activitymentioning

confidence: 99%