We present an effective implementation of the PRIME+PROBE side-channel attack against the lastlevel cache. We measure the capacity of the covert channel the attack creates and demonstrate a cross-core, cross-VM attack on multiple versions of GnuPG. Our technique achieves a high attack resolution without relying on weaknesses in the OS or virtual machine monitor or on sharing memory between attacker and victim.

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We propose and experimentally demonstrate a temporal differentiator in optical field based on a silicon microring resonator with a radius of 40 microm. The microring resonator operates near the critical coupling region, and can take the first order derivative of the optical field. It features compact size thus is suitable for integration with silicon-on-insulator (SOI) based optical and electronic devices. The performance of this optical differentiator is tested using signals with typical shapes such as Gaussian, sinusoidal and square-like pulses at data rates of 10 Gb/s and 5 Gb/s.

Correctly functioning caches have been shown to leak critical secrets like encryption keys, through various types of cache side-channel attacks. This nullifies the security provided by strong encryption and allows confidentiality breaches, impersonation attacks and fake services. Hence, future cache designs must consider security, ideally without degrading performance and power efficiency. We introduce a new classification of cache side channel attacks: contention based attacks and reuse based attacks. Previous secure cache designs target only contention based attacks, and we show that they cannot defend against reuse based attacks. We show the surprising insight that the fundamental demand fetch policy of a cache is a security vulnerability that causes the success of reuse based attacks. We propose a novel random fill cache architecture that replaces demand fetch with random cache fill within a configurable neighborhood window. We show that our random fill cache does not degrade performance, and in fact, improves the performance for some types of applications. We also show that it provides information-theoretic security against reuse based attacks.

Hydrogel-based flexible strain sensors have shown great potential in body movement tracking, early disease diagnosis, noninvasive treatment, electronic skins, and soft robotics. The good self-healing, biocompatible, sensitive and stretchable properties are the focus of hydrogel-based flexible strain sensors. Dual network (DN) hydrogels are hopeful to fabricate self-healing hydrogels with the above properties. Here, multifunctional DN hydrogels are prepared via a combination of host−guest interaction of β-cyclodextrin and ferrocene with dynamic borate ester bonds of poly(vinyl alcohol) and borax. Carbon nanotubes are used to endow the DN hydrogels with good conductivity. The obtained DN composite hydrogels possess good biocompatibility, stretchability (436%), fracture strength (41.0 KPa), self-healing property (healing efficiency of 95%), and high tensile strain sensitivity (gauge factor of 5.9). The DN composite hydrogels are used as flexible strain sensors to detect different human motions. After cutting, the healed hydrogels also can monitor human motions and have good stability. In addition, the hydrogel sensors may track the respiratory movement of a pig lung in vitro. This work exhibits new ideas and approaches to develop multifunctional self-healing hydrogels for constructing flexible strain sensors.

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Oxidative stress plays an important role in aging-related neurodegeneration. This study used littermates of WT and Nox2-knockout (Nox2KO) mice plus endothelial cell–specific human Nox2 overexpression–transgenic (HuNox2Tg) mice to investigate Nox2-derived ROS in brain aging. Compared with young WT mice (3–4 months), aging WT mice (20–22 months) had obvious metabolic disorders and loss of locomotor activity. Aging WT brains had high levels of angiotensin II (Ang II) and ROS production; activation of ERK1/2, p53, and γH2AX; and losses of capillaries and neurons. However, these abnormalities were markedly reduced in aging Nox2KO brains. HuNox2Tg brains at middle age (11–12 months) already had high levels of ROS production and activation of stress signaling pathways similar to those found in aging WT brains. The mechanism of Ang II–induced endothelial Nox2 activation in capillary damage was examined using primary brain microvascular endothelial cells. The clinical significance of Nox2-derived ROS in aging-related loss of cerebral capillaries and neurons was investigated using postmortem midbrain tissues of young (25–38 years) and elderly (61–85 years) adults. In conclusion, Nox2 activation is an important mechanism in aging-related cerebral capillary rarefaction and reduced brain function, with the possibility of a key role for endothelial cells.