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Purpose – The purpose of this paper is to contribute to the debate on the development of academic libraries, by the introduction of the concepts of co-working and innovation to the learning centres. Design/methodology/approach – The paper builds on published case studies and French initiatives. Findings – The proposal of this paper is that the academic library can meet its social responsibility on the campus and in society by drawing on the model of the co-working spaces and communities, by the support of innovation and the transfer of knowledge to the world of work. Moreover, the proposal is to include these new functions into the concept of learning centre, i.e. to develop the work-related aspects of the learning centre. Research limitations/implications – Future research on academic libraries should focus on social responsibility and their contribution not only to students’ academic success but also to students’ employability and to the transfer of technology. Practical implications – The paper contributes to the development and marketing of new academic library services and to its strategic positioning on the campus. Originality/value – Co-working and innovation are relatively new but promising concepts for academic libraries. Except for some recent case studies, conceptual papers are still missing that combine empirical experience with a theoretical approach.

Nature is considered a prolific source of diverse biologically active chemotypes. While most reviews have focused on the characteristics of the chemical backbones of natural products (NPs), few have tried to provide an overview of their origins (the living organisms in which they are produced), chemical classes, and biological activities. This review discusses the current knowledge on NP diversity by focusing on the Dictionary of Natural Products® (DNP). We datamined the 300,000 NPs covered by the DNP to reveal relevant, albeit dormant, knowledge about NP diversity.%This holistic picture of NPs allows us to discuss the most abundant biological sources of NPs investigated in relation to their chemical features and biological activities. In a nutshell, a large part of NPs originated from plants (67%), especially from the Compositae and Leguminosae families. Among all kingdoms, NPs isolated from Streptomyces spp. were largely represented, while terpenoids and alkaloids were the two most represented chemical classes. Out of all NPs documented, only 3,882 were reported to be bioactive (1,163 from plants and 1,006 from bacteria), with antibacterial, antibiotics, and antineoplastic agents being the most frequent therapeutic classes. In this paper, we also address the advantages and limitations of NP research from a pharmaceutical industry perspective. This work will provide useful insights and guidance to researchers involved in drug discovery from NPs.

In an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn's disease have a high risk of anal cancer, including perianal fistula-related cancer, and a high risk of rectal cancer.

OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. Any correspondance concerning this service should be sent to the repository administrator: staff-oatao@listes-diff.inp-toulouse.fr Abstract Scholarly publications reify fruitful collaborations between co-authors. A branch of research in the Science Studies focuses on analyzing the co-authorship networks of established scientists. Such studies tell us about how their collaborations developed through their careers. This paper updates previous work by reporting a transversal and a longitudinal studies spanning the lifelong careers of a cohort of researchers from the DBLP bibliographic database. We mined 3,860 researchers' publication records to study the evolution patterns of their co-authorships. Two features of co-authors were considered: 1) their expertise, and 2) the history of their partnerships with the sampled researchers. Our findings reveal the ephemeral nature of most collaborations: 70% of the new co-authors were only one-shot partners since they did not appear to collaborate on any further publications. Overall, researchers consistently extended their co-authorships 1) by steadily enrolling beginning researchers (i.e., people who had never published before), and 2) by increasingly working with confirmed researchers with whom they already collaborated.

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Abstract.To evaluate Information Retrieval Systems on their effectiveness, evaluation programs such as TREC offer a rigorous methodology as well as benchmark collections. Whatever the evaluation collection used, effectiveness is generally considered globally, averaging the results over a set of information needs. As a result, the variability of system performance is hidden as the similarities and differences from one system to another are averaged. Moreover, the topics on which a given system succeeds or fails are left unknown. In this paper we propose an approach based on data analysis methods (correspondence analysis and clustering) to discover correlations between systems and to find trends in topic/system correlations. We show that it is possible to cluster topics and systems according to system performance on these topics, some system clusters being better on some topics. Finally, we propose a new method to consider complementary systems as based on their performances which can be applied for example in the case of repeated queries. We consider the system profile based on the similarity of the set of TREC topics on which systems achieve similar levels of performance. We show that this method is effective when using the TREC ad hoc collection.

Este artigo tem por objetivo apresentar e analisar de maneira crítica os novos instrumentos de planejamento da gestão dos recursos hídricos na França, criados pela lei de 1992; relatar como foi conduzida a elaboração da primeira versão dos SDAGE's, que estão em vigor desde 1997 juntamente com o 7° Programa das Agências de Água; apresentar como estão sendo elaborados os SAGE's e, desta forma, oferecer uma contribuição para o debate que está acontecendo no Brasil sobre a utilização dos Planos de Recursos Hídricos. Palavras-chave: instrumentos de gestão dos recursos hídricos; planejamento dos recursos hídricos; gerenciamento de recursos hídricos.