In the current trend toward miniaturization, integrated micro-optical elements play a central role in the development of various applications including high-density data storage and imaging. In these operations, fine alignment and focus adjustment are usually performed mechanically, thus, limiting the accuracy, size and speed of devices. Here, we propose a novel reconfigurable microlens based on the engineering of the temperature distribution induced by a patterned plasmonic surface shined with a resonant nearinfrared light. The refractive index change generated in a surrounding thermo-optical material acts as an effective lens whose parameters are remotely adjusted by the control nearinfrared light. We demonstrate focal distance tunability of tens of microns with subnanometer accuracy along with timeresponses down to 200 μs. The applicability of this photothermal lens is proved in the framework of optical microscopy and adaptive optics.

Owing to their unique chemical and physical properties, colloidal gold nanoparticles have prompted a wide variety of biocompatible nano-agents for cancer imaging, diagnosis and treatment. In this context, biofunctionalized gold nanorods (AuNRs) are promising candidates for light-induced hyperthermia, to cause local and selective damage in malignant tissue. Yet, the efficacy of AuNR-based hyperthermia is highly dependent on several experimental parameters; in particular, the AuNR morphology strongly affects both physical and biological processes. In the present work, we systematically study the influence of different structural parameters like the AuNR aspect ratio, length and molecular weight on in vitro cytotoxicity, cellular uptake and heat generation efficiency. Our results enable us to identify the optimum AuNR morphology to be used for in vivo hyperthermia treatment.

A scanning system for small animal imaging using non-contact, hybrid broadband diffuse optical spectroscopy (ncDOS) and diffuse correlation spectroscopy (ncDCS) is presented. The ncDOS uses a two-dimensional spectrophotometer retrieving broadband (610-900 nm) spectral information from up to fifty-seven sourcedetector distances between 2 and 5 mm. The ncDCS data is simultaneously acquired from four source-detector pairs. The sample is scanned in two dimensions while tracking variations in height. The system has been validated with liquid phantoms, demonstrated in vivo on a human fingertip during an arm cuff occlusion and on a group of mice with xenoimplanted renal cell carcinoma. ©2016 Optical Society of America

TPL microscopy is able to study and quantify the delivery mechanisms of nanoparticles, highly relevant to the development of nanomedicines.

The ex vivo and in vivo imaging, and quantitative characterization of the degradation of surgical sutures (∼500 μm diameter) up to ∼1cm depth is demonstrated using a custom dark-field photo-acoustic microscope (PAM). A practical algorithm is developed to accurately measure the suture diameter during the degradation process. The results from tissue simulating phantoms and mice are compared to ex vivo measurements with an optical microscope demonstrating that PAM has a great deal of potential to characterize the degradation process of surgical sutures. The implications of this work for industrial applications are discussed.

The longitudinal, non-invasive, in vivo quantification of the PEG-coated gold nanorod (AuNR–PEG) concentration and tissue hemodynamics by hybrid diffuse optical methods.

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