Sexual minorities are at increased risk for multiple mental health burdens compared to heterosexuals. The field has identified two distinct determinants of this risk, including group-specific minority stressors and general psychological processes that are common across sexual orientations. The goal of the present paper is to develop a theoretical framework that integrates the important insights from these literatures. The framework postulates that (a) sexual minorities confront increased stress exposure resulting from stigma; (b) this stigma-related stress creates elevations in general emotion dysregulation, social/interpersonal problems, and cognitive processes conferring risk for psychopathology; and (c) these processes in turn mediate the relationship between stigma-related stress and psychopathology. It is argued that this framework can, theoretically, illuminate how stigma adversely affects mental health and, practically, inform clinical interventions. Evidence for the predictive validity of this framework is reviewed, with particular attention paid to illustrative examples from research on depression, anxiety, and alcohol use disorders.Keywords stigma-related stress; general psychological processes; mediation; LGB populations; mental health disparities Epidemiological research has revealed multiple mental health burdens among sexual minority 1 populations, relative to heterosexuals (Cochran, 2001). Having established this risk, two separate literatures have focused on identifying factors creating this risk. The first literature has focused on group-specific processes, in the form of sexual minority stress (Meyer, 2003), whereas the second literature has emphasized general psychological processes (Diamond, 2003;Savin-Williams, 2001) that explain the development of psychopathological outcomes in both sexual minorities and heterosexuals. The field now requires a framework that draws on and integrates the important insights gained from these three distinct literatures: (a) psychiatric epidemiology; (b) social generation of stigma through stress; and (c) general psychological processes. The goal of the present paper is the development of such a framework that elucidates potential psychological pathways linking stigma-related stressors to adverse mental health outcomes. The paper's central premise is that a comprehensive framework of mental health Publisher's Disclaimer: The following manuscript is the final accepted manuscript. It has not been subjected to the final copyediting, fact-checking, and proofreading required for formal publication. It is not the definitive, publisher-authenticated version. The American Psychological Association and its Council of Editors disclaim any responsibility or liabilities for errors or omissions of this manuscript version, any version derived from this manuscript by NIH, or other third parties. The published version is available at www.apa.org/journals/bul. 1 There are multiple operationalizations of sexual orientation, including self-identification (gay, lesbian, or ...

Bodies of research pertaining to specific stigmatized statuses have typically developed in separate domains and have focused on single outcomes at 1 level of analysis, thereby obscuring the full significance of stigma as a fundamental driver of population health. Here we provide illustrative evidence on the health consequences of stigma and present a conceptual framework describing the psychological and structural pathways through which stigma influences health. Because of its pervasiveness, its disruption of multiple life domains (e.g., resources, social relationships, and coping behaviors), and its corrosive impact on the health of populations, stigma should be considered alongside the other major organizing concepts for research on social determinants of population health.

Living in states with discriminatory policies may have pernicious consequences for the mental health of LGB populations. These findings lend scientific support to recent efforts to overturn these policies.

Psychological research has provided essential insights into how stigma operates to disadvantage those who are targeted by it. At the same time, stigma research has been criticized for being too focused on the perceptions of stigmatized individuals and on micro-level interactions, rather than attending to structural forms of stigma. This article describes the relatively new field of research on structural stigma, which is defined as societal-level conditions, cultural norms, and institutional policies that constrain the opportunities, resources, and wellbeing of the stigmatized. I review emerging evidence that structural stigma related to mental illness and sexual orientation (1) exerts direct and synergistic effects on stigma processes that have long been the focus of psychological inquiry (e.g., concealment, rejection sensitivity); (2) serves as a contextual moderator of the efficacy of psychological interventions; and (3) contributes to numerous adverse health outcomes for members of stigmatized groups-ranging from dysregulated physiological stress responses to premature mortality-indicating that structural stigma represents an under-recognized mechanism producing health inequalities. Each of these pieces of evidence suggests that structural stigma is relevant to psychology and therefore deserves the attention of psychological scientists interested in understanding and ultimately reducing the negative effects of stigma.

Background Emotion regulation deficits have been consistently linked to psychopathology in cross-sectional studies. However, the direction of the relationship between emotion regulation and psychopathology is unclear. This study examined the longitudinal and reciprocal relationships between emotion regulation deficits and psychopathology in adolescents. Methods Emotion dysregulation and symptomatology (depression, anxiety, aggressive behavior, and eating pathology) were assessed in a large, diverse sample of adolescents (N = 1,065) at two time points separated by seven months. Structural equation modeling was used to examine the longitudinal and reciprocal relationships between emotion dysregulation and symptoms of psychopathology. Results The three distinct emotion processes examined here (emotional understanding, dysregulated expression of sadness and anger, and ruminative responses to distress) formed a unitary latent emotion dysregulation factor. Emotion dysregulation predicted increases in anxiety symptoms, aggressive behavior, and eating pathology after controlling for baseline symptoms but did not predict depressive symptoms. In contrast, none of the four types of psychopathology predicted increases in emotion dysregulation after controlling for baseline emotion dysregulation. Conclusions Emotion dysregulation appears to be an important transdiagnostic factor that increases risk for a wide range of psychopathology outcomes in adolescence. These results suggest targets for preventive interventions during this developmental period of risk.

Objectives We tested the preliminary efficacy of a transdiagnostic cognitive behavioral treatment adapted to improve depression, anxiety, and co-occurring health risks (i.e., alcohol use, sexual compulsivity, condomless sex) among young adult gay and bisexual men. Treatment adaptations focused on reducing minority stress processes that underlie sexual orientation-related mental health disparities. Method Young gay and bisexual men (n=63; M age=25.94) were randomized to immediate treatment or a three-month waitlist. At baseline, 3-month, and 6-month assessments, participants completed self-reports of mental health and minority stress and an interview of past-90-day risk behavior. Results Compared to waitlist, treatment significantly reduced depressive symptoms (b=−2.43, 95% CI: −4.90, 0.35, p<0.001), alcohol use problems (b =−3.79, 95% CI: −5.94, −1.64, p<0.001), sexual compulsivity (b =−5.09, 95% CI: −8.78, −1.40, p<0.001), and past-90-day condomless sex with casual partners (b =−1.09, 95% CI: −1.80, −0.37, p<0.001), and improved condom use self-efficacy (b =10.08, 95% CI: 3.86, 16.30, p<0.001). The treatment yielded moderate and marginally significant greater improvements than waitlist in anxiety symptoms (b =−2.14, 95% CI: −4.61, 0.34, p=0.09) and past-90-day heavy drinking (b =−0.32, 95% CI: −0.71, 0.07, p=0.09). Effects were generally maintained at follow-up. Minority stress processes showed small improvements in the expected direction. Conclusion This study demonstrated preliminary support for the first intervention adapted to address gay and bisexual men’s co-occurring health problems at their source in minority stress. If found to be efficacious compared to standard evidence-based treatments, the treatment will possess substantial potential for helping clinicians translate LGB-affirmative treatment guidelines into evidence-based practice. Public Health Significance Sexual orientation-related disparities in depression and anxiety co-occur with alcohol use, sexual compulsivity, and risky sexual behavior to form a syndemic health threat surrounding young gay and bisexual men. Clear and consistent evidence suggests that a major source of this syndemic is minority stress—the stress associated with stigma-related social disadvantage that compounds general life stress. This study represents the first test of an adapted cognitive behavioral intervention designed to alleviate minority stress among young gay and bisexual men to improve the co-occurring health conditions facing this population.

This study documents an association between an objective measure of the social environment and suicide attempts among lesbian, gay, and bisexual youth. The social environment appears to confer risk for suicide attempts over and above individual-level risk factors. These results have important implications for the development of policies and interventions to reduce sexual orientation-related disparities in suicide attempts.

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