Peter J. Sheridan scite author profile

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.

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Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism

Blum

Noble²,

Sheridan³

et al. 1990

JAMA

835

277

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Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour

et al. 1995

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Allelic association of the D2 dopamine receptor gene with cocaine dependence

Noble

Blum

Khalsa

et al. 1993

Drug and Alcohol Dependence

242

127

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Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism

Blum

Noble

Sheridan

et al. 1991

Alcohol

212

108

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Increased prevalence of the Taq I A1allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report

et al. 1996

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Sibship Size, Sibling Sex Ratio, Birth Order, and Parental Age in Homosexual and Nonhomosexual Gender Dysphorics

Blanchard¹,

Sheridan²

1992

The Journal of Nervous and Mental Disease

100

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Peter J. Sheridan

Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism

The D₂ Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome

Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism

Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour

Allelic association of the D2 dopamine receptor gene with cocaine dependence

Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism

Increased prevalence of the Taq I A1allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report

Sibship Size, Sibling Sex Ratio, Birth Order, and Parental Age in Homosexual and Nonhomosexual Gender Dysphorics

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Peter J. Sheridan

Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism

The D2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome

Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism

Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour

Allelic association of the D2 dopamine receptor gene with cocaine dependence

Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism

Increased prevalence of the Taq I A1allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report

Sibship Size, Sibling Sex Ratio, Birth Order, and Parental Age in Homosexual and Nonhomosexual Gender Dysphorics

Contact Info

Product

Resources

About

The D₂ Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome